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Showing 1–50 of 55 results

Advanced filters: Author: Shruti Sharma Clear advanced filters

National identity predicts public health support during a global pandemic

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Validation of a methylation-based, tissue-free MRD assay in colorectal cancer patients from the GALAXY study

Yoshiaki Nakamura
Johannes G. Reiter
Takayuki Yoshino
ResearchOpen Access19 Jan 2026
npj Precision Oncology

P: 1-9
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Scrutinizing the inherent half-metallicity, electronic structure, mechanical stability, optical and thermoelectric response of d-electron based Sc₂VX (X = Si, Ge) Heusler alloys

Shruti Sharma
Dinesh C. Gupta
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-24
Longitudinal circulating tumor DNA analysis during treatment of locally advanced resectable gastric or gastroesophageal junction adenocarcinoma: the PLAGAST prospective biomarker study

Despite pre- and post-operative treatment, patients with locally advanced resectable gastric/gastroesophageal junction adenocarcinomas have a high recurrence risk. Here, the authors analyse a prospective cohort of patients and find ctDNA status is correlated with survival outcomes.

Aziz Zaanan
Audrey Didelot
Pierre Laurent-Puig
ResearchOpen Access24 Jul 2025
Nature Communications

Volume: 16, P: 1-10
Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.

Shruti Sharma
Antonio Carmona
Kai S. Erdmann
ResearchOpen Access15 Jul 2019
Nature Communications

Volume: 10, P: 1-16
ctDNA-based molecular residual disease and survival in resectable colorectal cancer

In a large cohort with a 23-month median follow-up of the CIRCULATE-Japan GALAXY observational study, ctDNA-based detection of molecular residual disease was predictive of survival outcomes and benefit of adjuvant chemotherapy in patients with resectable colorectal cancer.

Yoshiaki Nakamura
Jun Watanabe
Eiji Oki
ResearchOpen Access16 Sept 2024
Nature Medicine

Volume: 30, P: 3272-3283
Cholesterol-targeting Wnt–β-catenin signaling inhibitors for colorectal cancer

Locally elevated cholesterol in colorectal cancer cells with adenomatous polyposis coli truncation was observed to drive Wnt–β-catenin signaling through Dishevelled (Dvl). Inhibitors targeting the cholesterol–Dvl interaction potently suppress tumor growth without adverse side effects.

Ashutosh Sharma
Julian Zalejski
Wonhwa Cho
Research16 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1376-1386
Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer

In the observational GALAXY arm of the CIRCULATE-Japan study, among 1,049 patients with stage II–IV colorectal cancer, those with presence of circulating tumor DNA (ctDNA) after tumor resection have a high recurrence risk and are likely to benefit from adjuvant chemotherapy.

Daisuke Kotani
Eiji Oki
Takayuki Yoshino
ResearchOpen Access16 Jan 2023
Nature Medicine

Volume: 29, P: 127-134
Assessment of circulating tumor DNA in patients with locally advanced rectal cancer treated with neoadjuvant therapy

Chiara Molinari
Giorgia Marisi
Alessandro Passardi
ResearchOpen Access28 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Profiling CARD14 gene expression in Indian Psoriasis patients

S. Singh
D. Pradhan
A. K. Jain
ResearchOpen Access20 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial

A neoadjuvant treatment regimen of anti-PD-L1 monotherapy followed by anti-PD-L1 plus chemotherapy was well tolerated and led to a major pathologic response rate of 70% in patients with resectable gastric or gastroesophageal junction adenocarcinoma.

Yara L. Verschoor
Joris van de Haar
Myriam Chalabi
ResearchOpen Access08 Jan 2024
Nature Medicine

Volume: 30, P: 519-530
Conformational dynamics of ligand-dependent alternating access in LeuT

LeuT is a Na⁺-coupled amino acid transporter that is similar in sequence and function to eukaryotic neurotransmitter/sodium symporters, which are active in reuptake of neurotransmitters from the synapse. Distance measurements between spin-label pairs are used to identify ligand-dependent structural transitions in LeuT.

Kelli Kazmier
Shruti Sharma
Hassane S Mchaourab
Research20 Apr 2014
Nature Structural & Molecular Biology

Volume: 21, P: 472-479
Retrospective analysis of neoplasms in patients using angiotensin receptor blockers

Arvind Kumar Sharma
Shruti Rastogi
Ramesh K. Goyal
ResearchOpen Access09 Jul 2024
Scientific Reports

Volume: 14, P: 1-7
An Untargeted LC–MS based approach for identification of altered metabolites in blood plasma of rheumatic heart disease patients

Soumi Das
Yashwant Kumar
Gautam Sharma
ResearchOpen Access28 Mar 2022
Scientific Reports

Volume: 12, P: 1-7
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

The authors report on prospective exploratory analyses of circulating tumour DNA in an urothelial carcinoma immunotherapy clinical trial.

Thomas Powles
Zoe June Assaf
Sanjeev Mariathasan
Research16 Jun 2021
Nature

Volume: 595, P: 432-437
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Improved reference genome of Aedes aegypti informs arbovirus vector control

An improved, fully re-annotated Aedes aegypti genome assembly (AaegL5) provides insights into the sex-determining M locus, chemosensory systems that help mosquitoes to hunt humans and loci involved in insecticide resistance and will help to generate intervention strategies to fight this deadly disease vector.

Benjamin J. Matthews
Olga Dudchenko
Leslie B. Vosshall
ResearchOpen Access14 Nov 2018
Nature

Volume: 563, P: 501-507
De novo variants underlying monogenic syndromes with intellectual disability in a neurodevelopmental cohort from India

Shruti Pande
Purvi Majethia
Anju Shukla
ResearchOpen Access20 Dec 2023
European Journal of Human Genetics

Volume: 32, P: 1291-1298
Catenin' on to nucleic acid sensing

Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.

Vijay A K Rathinam
Shruti Sharma
Katherine A Fitzgerald
News & Views01 Jun 2010
Nature Immunology

Volume: 11, P: 466-468
Multilocus disease-causing genomic variations for Mendelian disorders: role of systematic phenotyping and implications on genetic counselling

Dhanya Lakshmi Narayanan
Divya Udyawar
Anju Shukla
ResearchOpen Access19 Jul 2021
European Journal of Human Genetics

Volume: 29, P: 1774-1780
Author Correction: Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial

Yara L. Verschoor
Joris van de Haar
Myriam Chalabi
Amendments and CorrectionsOpen Access06 Mar 2024
Nature Medicine

Volume: 30, P: 1499
IFI16 is an innate immune sensor for intracellular DNA

Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β production in a STING-TBK1-IRF3 signaling pathway.

Leonie Unterholzner
Sinead E Keating
Andrew G Bowie
Research03 Oct 2010
Nature Immunology

Volume: 11, P: 997-1004
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

New approaches are required to combatPlasmodium falciparuminfection. In this proteome-wide study, 1305 phosphorylation sites are identified and 36 kinases are shown to have crucial roles in parasite survival, providing new insights into parasite biology and potential new drug targets for anti-malarial chemotherapy.

Lev Solyakov
Jean Halbert
Christian Doerig
ResearchOpen Access29 Nov 2011
Nature Communications

Volume: 2, P: 1-12
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

The AIM2 inflammasome induces maturation of the proinflammatory cytokines IL-1β and IL-18. Using AIM2-deficient mice, Fitzgerald and colleagues and Alnemri and colleagues show that the AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.

Vijay A K Rathinam
Zhaozhao Jiang
Katherine A Fitzgerald
Research28 Mar 2010
Nature Immunology

Volume: 11, P: 395-402
A genome-wide map of circular RNAs in adult zebrafish

Disha Sharma
Paras Sehgal
Sridhar Sivasubbu
ResearchOpen Access05 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
Fatigue in children and young people up to 24 months after infection with SARS-CoV-2

Alvin Richards-Belle
Roz Shafran
Elizabeth Whittaker
ResearchOpen Access20 Nov 2025
Scientific Reports

Volume: 15, P: 1-11
Design & development of customizable web API for interoperability of antimicrobial resistance data

Jasleen Kaur
Jasmine Kaur
Harpreet Singh
ResearchOpen Access27 May 2021
Scientific Reports

Volume: 11, P: 1-10
Generation and characterization of a Müller-glial-cell-specific Il6ra knockout mouse to delineate the effects of IL-6 trans-signaling in the retina

Rebekah Robinson
Joshua Glass
Shruti Sharma
ResearchOpen Access21 Oct 2022
Scientific Reports

Volume: 12, P: 1-12
Author Correction: National identity predicts public health support during a global pandemic

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio
Amendments and CorrectionsOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-2
Systematic investigation of structural, magneto-electronic, mechanical, thermophysical, optical and thermoelectric properties of Hf₂VZ (Z = Ga, In, Tl) inverse Heusler alloy for spintronics applications

Shruti Sharma
Dinesh C. Gupta
ResearchOpen Access18 Nov 2024
Scientific Reports

Volume: 14, P: 1-23
Enhancement of optical limiting activity of para-aminobenzoic acid using silver nanoparticles

Shradha Lakhera
Meenakshi Rana
Devendra Kumar
ResearchOpen Access23 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

A diagnostic tool based on blood RNA-seq is shown to identify causal genes and variants linked to clinical phenotypes in individuals with rare diseases for which whole-exome genetic sequencing was uninformative.

Laure Frésard
Craig Smail
Stephen B. Montgomery
Research03 Jun 2019
Nature Medicine

Volume: 25, P: 911-919
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis

Fangyan Yu
Shruti Sharma
Kai Sven Erdmann
ResearchOpen Access21 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis

Vishnu Prasoodanan P. K.
Ashok K. Sharma
Vineet K. Sharma
ResearchOpen Access07 Oct 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-17
Antibody and Memory B Cell Responses in Hepatitis E Recovered Individuals, 1–30 Years Post Hepatitis E Virus Infection

Shruti P. Kulkarni
Meenal Sharma
Anuradha S. Tripathy
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow

Peter E. Oishi
Shruti Sharma
Jeffrey R. Fineman
Research05 Nov 2012
Pediatric Research

Volume: 73, P: 54-61
Genome sequencing and functional analysis of a multipurpose medicinal herb Tinospora cordifolia (Giloy)

Shruti Mahajan
Abhisek Chakraborty
Vineet K. Sharma
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-17
Silicon tackles butachlor toxicity in rice seedlings by regulating anatomical characteristics, ascorbate-glutathione cycle, proline metabolism and levels of nutrients

Durgesh Kumar Tripthi
Rishi Kumar Varma
Shivendra Sahi
ResearchOpen Access21 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
Revisiting current distribution and future habitat suitability models for the endemic Malabar Tree Toad (Pedostibes tuberculosus) using citizen science data

C. K. Aravind
Hebbar Priti
Kotambylu Vasudeva Gururaja
ResearchOpen Access14 Aug 2024
Scientific Reports

Volume: 14, P: 1-20
A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people

Stephenson, Pinto Pereira et al. investigate the proportion of children and young people with Post Covid-19 condition 24-months post-infection. Only 7.2% meet the definition consistently at 3-, 6-, 12- and 24-months post-infection, highlighting the importance of longitudinal studies.

Terence Stephenson
Snehal M. Pinto Pereira
Roz Shafran
ResearchOpen Access04 Dec 2024
Communications Medicine

Volume: 4, P: 1-12
Genome sequencing of turmeric provides evolutionary insights into its medicinal properties

Chakraborty et al. present the draft genome of turmeric and transcriptome of leaf tissue. Phylogenetic and comparative evolutionary analyses show evolution in genes associated with secondary metabolism, plant phytohormones signaling, and various biotic and abiotic stress tolerance responses.

Abhisek Chakraborty
Shruti Mahajan
Vineet K. Sharma
ResearchOpen Access15 Oct 2021
Communications Biology

Volume: 4, P: 1-12
A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative

Vandana Shashi
Kelly Schoch
Allison Zheng
Research15 Jun 2018
Genetics in Medicine

Volume: 21, P: 161-172
Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India

Pawan Kumar
Satyabrata Bag
Bhabatosh Das
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
Multiple Kernel Learning Model for Relating Structural and Functional Connectivity in the Brain

Sriniwas Govinda Surampudi
Shruti Naik
Dipanjan Roy
ResearchOpen Access19 Feb 2018
Scientific Reports

Volume: 8, P: 1-14
Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study

Snehal M. Pinto Pereira
Manjula D. Nugawela
Roz Shafran
ResearchOpen Access30 Apr 2024
Scientific Reports

Volume: 14, P: 1-11
Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

Ashok Sharma
Maria L. Valle
Shruti Sharma
Reviews24 Jan 2019
Eye

Volume: 33, P: 534-541
Social and moral psychology of COVID-19 across 69 countries

Flavio Azevedo
Tomislav Pavlović
Waldir M. Sampaio
ResearchOpen Access11 May 2023
Scientific Data

Volume: 10, P: 1-26
Author Correction: PLAS-20k: Extended Dataset of Protein-Ligand Affinities from MD Simulations for Machine Learning Applications

Divya B. Korlepara
C. S. Vasavi
U. Deva Priyakumar
Amendments and CorrectionsOpen Access04 Jul 2024
Scientific Data

Volume: 11, P: 1-2
A collaborative model for capacity building of primary care physicians in the management of Hypertension in India

Anshika Sharma
Arun Pulikkottil Jose
Ambuj Roy
Comments & Opinion01 Jul 2019
Journal of Human Hypertension

Volume: 33, P: 562-565

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