Nature Search

Relationship between adjustability of grasping force and upper limb/hand function in individuals with cerebrovascular disorders

Tatsuya Kaneno
Katsutoshi Kawahara
Yoshifumi Morita
ResearchOpen Access04 Feb 2026
Scientific Reports

P: 1-9
Glucose-Sensitive Lower Critical Solution Temperature Changes of Copolymers Composed of N-Isopropylacrylamide and Phenylboronic Acid Moieties

Takashi Aoki
Yayoi Nagao
Teruo Okano
Research01 Apr 1996
Polymer Journal

Volume: 28, P: 371-374
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Meta-analyses of genome-wide association studies identify novel loci influencing Japanese white matter hyperintensities

Yuya Asanomi
Risa Mitsumori
Kouichi Ozaki
ResearchOpen Access20 Jan 2026
Journal of Human Genetics

P: 1-7
Stiff-Chain Behavior of Poly(terephthalamide-P-benzohydrazide) in Dimethyl Sulfoxide

Kazuo Sakurai
Kenmei Ochi
Hiroshi Fujita
Research01 Jul 1984
Polymer Journal

Volume: 16, P: 559-567
Updated analysis of pathogenic variants in BRCA1/BRCA2 among the general Japanese population

Tasuku Mariya
Masashi Idogawa
Akihiro Sakurai
ResearchOpen Access21 Jan 2026
Human Genome Variation

Volume: 13, P: 1-3
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Orexin modulates behavioral fear expression through the locus coeruleus

Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons and enhance fear expression and generalization.

Shingo Soya
Tohru M. Takahashi
Takeshi Sakurai
ResearchOpen Access20 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Formation of Porous Spherulites of Poly(L-lactide) Grown from Solutions

Takashi Sasaki
Ryuya Asakawa
Kensuke Sakurai
Research15 Jul 2009
Polymer Journal

Volume: 41, P: 787-791
Hard magnetic ferrite with a gigantic coercivity and high frequency millimetre wave rotation

Permanent magnets based on magnetic ferrites such as Fe₃O₄ and Fe₂O₃ are used in a wide range of applications. This study demonstrates that introducing rhodium into nanoparticles consisting of the ε phase of Fe₂O₃gives rise to a very high coercivity.

Asuka Namai
Marie Yoshikiyo
Shin-ichi Ohkoshi
ResearchOpen Access04 Sept 2012
Nature Communications

Volume: 3, P: 1-6
Historical and future learning for the new era of multi-terawatt photovoltaics

Solar photovoltaics is entering a multi-terawatt era, driven by decades of cost, performance and reliability gains. In this Perspective Alberi et al. discuss the role of historical and future learning, highlighting the increasing importance of sustainability considerations.

Kirstin Alberi
I. Marius Peters
Andreas W. Bett
Reviews23 Dec 2025
Nature Energy

Volume: 11, P: 38-46
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Close-up observations on the spawning behavior of a captive Japanese flying squid (Todarodes pacificus)

Jun Yamamoto
Kohsuke Adachi
Hae-Kyun Yoo
ResearchOpen Access24 Dec 2019
Scientific Reports

Volume: 9, P: 1-6
A compact X-ray free-electron laser emitting in the sub-ångström region

Researchers report sub-ångström fundamental-wavelength lasing at the SPring-8 Angstrom Compact Free-Electron Laser in Japan. The output has a maximum power of more than 10 GW, a pulse duration of 10⁻¹⁴ s and a lasing wavelength of 0.634 Å.

Tetsuya Ishikawa
Hideki Aoyagi
Noritaka Kumagai
Research24 Jun 2012
Nature Photonics

Volume: 6, P: 540-544
Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells

Jing-hua Yu
Hong-jun Wang
Takashi Ikejima
Research01 Sept 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1069-1076
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.

Nobuyuki Kakiuchi
Kenichi Yoshida
Seishi Ogawa
Research18 Dec 2019
Nature

Volume: 577, P: 260-265
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Stiff-Chain Nature of Poly(1-phenyl-1-propyne) in Dilute Solution

Takayuki Hirao
Akio Teramoto
Toshinobu Higashimura
Research01 Aug 1991
Polymer Journal

Volume: 23, P: 925-932
Core/Shell and Hollow Polymeric Capsules Prepared from Calcium Carbonate Whisker

Takashi Sasaki
Takayuki Kitagawa
Kensuke Sakurai
Research07 May 2005
Polymer Journal

Volume: 37, P: 434-438
CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress

CCDC141 modulates cardiac mechanoadaptation via Connectin/titin and Nesprin-1. Its loss disrupts mitochondrial and Ca²⁺ dynamics, impairs nuclear integrity, and heightens susceptibility to stress-induced heart failure and arrhythmias.

Akira Hanashima
Misaki Kimoto
Satoshi Mohri
ResearchOpen Access26 Nov 2025
Communications Biology

Volume: 8, P: 1-13
Erratum: Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

Tetsuya Kimura
Shigeyuki Nada
Atsushi Kumanogoh
Amendments and CorrectionsOpen Access27 Feb 2017
Nature Communications

Volume: 8, P: 1-2
Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations

Ryanodine receptor 2 (RyR2) is a Ca²⁺ release channel essential for cardiac excitation-contraction coupling. Here, the authors use structural and functional analysis to reveal RyR2 gating mechanism and its alterations by pathogenic mutations.

Takuya Kobayashi
Akihisa Tsutsumi
Haruo Ogawa
ResearchOpen Access20 May 2022
Nature Communications

Volume: 13, P: 1-15
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models.

Toshiko Yamazawa
Takuya Kobayashi
Takashi Murayama
ResearchOpen Access13 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Impact of cumulative blood pressure load during early pregnancy on the risk of low birth weight: the BOSHI study

This study evaluated the association between cumulative blood pressure (BP) load elevation during early pregnancy and the risk of low birth weight (LBW). Elevation of both cumulative systolic and diastolic BP load was associated with an increased risk of LBW, even when average BP remained within the normal range.

Hiroki Nobayashi
Seiya Izumi
Hirohito Metoki
ResearchOpen Access20 Oct 2025
Hypertension Research

Volume: 49, P: 550-559
Collapse of Randomly Coiled Schizophyllan in Mixtures of Water and Dimethylsulfoxide

Takahiro Sato
Kazuo Sakurai
Hiroshi Fujita
Research01 Jan 1983
Polymer Journal

Volume: 15, P: 87-96
The Viscoelastic Properties of Aqueous Poly(methacrylic acid) Solutions and Their Relations to Thermoreversible Gelation

Kunio Nakamura
Takashi Itoh
Tsurutaro Nakagawa
Research01 Dec 1992
Polymer Journal

Volume: 24, P: 1419-1427
Data collaboration analysis in predicting diabetes from a small amount of health checkup data

Go Uchitachimoto
Noriyoshi Sukegawa
Tetsuya Sakurai
ResearchOpen Access21 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
CD8⁺ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

Helminth infections are associated with a reduction in inflammatory pathology in rodent models of type 1 diabetes. Here, the authors show patient data and that trehalose (produced by H. polygyrus) can alter the microbiome of mice, inducing regulatory CD8⁺ T cells and reducing susceptibility to autoimmune diabetes.

Chikako Shimokawa
Tamotsu Kato
Hajime Hisaeda
ResearchOpen Access22 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Orchestrated ensemble activities constitute a hippocampal memory engram

The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory.

Khaled Ghandour
Noriaki Ohkawa
Kaoru Inokuchi
ResearchOpen Access14 Jun 2019
Nature Communications

Volume: 10, P: 1-14
Immune evasion through mitochondrial transfer in the tumour microenvironment

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Hideki Ikeda
Katsushige Kawase
Yosuke Togashi
ResearchOpen Access22 Jan 2025
Nature

Volume: 638, P: 225-236
Synthesis and Swelling/De-swelling Behavior of Core-Shell Type Gel Consisting of Two Different Poly(N-alkylacrylamide) Gel Layers

Takashi Iizawa
Akihiro Terao
Yukio Onohara
Research26 Sept 2007
Polymer Journal

Volume: 39, P: 1177-1184
Lewis acid-mediated Suzuki–Miyaura cross-coupling reaction

The Suzuki–Miyaura cross-coupling (SMC) usually involves a base-mediated transmetalation, which is problematic for substrates with base-sensitive moieties. To tackle this issue, a Lewis acid-mediated SMC reaction is reported allowing high yields for very base-sensitive systems.

Takashi Niwa
Yuta Uetake
Takamitsu Hosoya
ResearchOpen Access17 Dec 2021
Nature Catalysis

Volume: 4, P: 1080-1088
Synthesis of Thermo-Sensitive Poly(N-isopropylacrylamide) Gel by Amidation of Poly(acrylic acid) Gel

Takashi Iizawa
Naoki Matsuno
Fumihiko Matsuda
Research01 Dec 1999
Polymer Journal

Volume: 31, P: 1277-1280
Synthesis and Polymerization of Novel Vinyl Monomers having Intramolecular Urethane Bond and Glycerin Group

Eui-Chul Kang
Atsuhiko Ogura
Yutaka Maruhashi
Research04 Oct 2006
Polymer Journal

Volume: 38, P: 1205-1209
DNA typing of HLA in the patients with moyamoya disease

Takuya K. Inoue
Kiyonobu Ikezaki
Masashi Fukui
Research01 Dec 1997
Japanese Journal of Human Genetics

Volume: 42, P: 507-515
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors

Akiyoshi Nakayama
Hirotaka Matsuo
Nariyoshi Shinomiya
ResearchOpen Access09 Jun 2014
Scientific Reports

Volume: 4, P: 1-5
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

The role of nutrient-sensing pathways in regulation of innate immune response is unexplored. Here the authors show that IL-4 activates the amino-acid sensing pathway in macrophages and leads to polarization of anti-inflammatory M2 macrophages via the transcription factor liver X receptor.

Tetsuya Kimura
Shigeyuki Nada
Atsushi Kumanogoh
ResearchOpen Access12 Oct 2016
Nature Communications

Volume: 7, P: 1-17
Endoscopic resection for local residual or recurrent cancer after definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma

Yasuhiro Tani
Ryu Ishihara
Tomoki Michida
ResearchOpen Access28 Jun 2023
Scientific Reports

Volume: 13, P: 1-8
Ultracompact mirror device for forming 20-nm achromatic soft-X-ray focus toward multimodal and multicolor nanoanalyses

Optics used for X-ray focusing suffer from wavelength dependent effects like chromatic aberration. Here the authors demonstrate fabrication of a ultracompact Kirkpatrick-Baez mirror and use it for achromatic focusing to 20 nm spot for the soft X-ray at 2-keV photon energy.

Takenori Shimamura
Yoko Takeo
Hidekazu Mimura
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Plant growth acceleration using a transparent Eu³⁺-painted UV-to-red conversion film

Sunao Shoji
Hideyuki Saito
Yasuchika Hasegawa
ResearchOpen Access26 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
Alteration of specific cytokine expression patterns in patients with breast cancer

Kosuke Kawaguchi
Masashi Sakurai
Masakazu Toi
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Associations of Sleep-Disordered Breathing with Excessive Daytime Sleepiness and Blood Pressure in Japanese Women

Renzhe Cui
Takeshi Tanigawa
Hiroyasu Iso
Research01 Mar 2008
Hypertension Research

Volume: 31, P: 501-506
Organic photostimulated luminescence associated with persistent spin-correlated radical pairs

Materials that display photostimulated luminescence are attractive for multiple applications. Here, photostimulated luminescence is demonstrated in an all-organic blend film, in which a dopant molecule functions as both an electron trap and a light emitter.

Manabu Sakurai
Ryota Kabe
Takashi Tachikawa
ResearchOpen Access13 Jul 2021
Communications Materials

Volume: 2, P: 1-7
Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data

Yuya Asanomi
Daichi Shigemizu
Shumpei Niida
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Influence of a Photo-Acid Generator on the Photoreactivity of a Photosensitive Polyimide Containing Epoxy Groups

Han Sung Yu
Takashi Yamashita
Kazuyuki Horie
Research01 Aug 1996
Polymer Journal

Volume: 28, P: 703-707
Double-Stranded Helix of Xanthan: Dissociation Behavior in Mixtures of Water and Cadoxen

Takahiro Sato
Takashi Norisuye
Hiroshi Fujita
Research01 May 1985
Polymer Journal

Volume: 17, P: 729-735

Search

Filter By:

Search

Quick links