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Scientific Reports (72)
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Showing 51–100 of 185 results

Advanced filters: Author: Takeshi Abe Clear advanced filters

Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling

The mouse segmentation clock regulates the periodicity of somite formation. Okubo and colleagues investigate the mechanisms underlying the synchronization of the clock in embryonic chimaeras and find that the synchronization is regulated by the protein Lfng, which represses Notch signalling in neighbouring cells.

Yusuke Okubo
Takeshi Sugawara
Yumiko Saga
Research16 Oct 2012
Nature Communications

Volume: 3, P: 1-9
Structure and mechanism of the mammalian fructose transporter GLUT5

This study has determined the X-ray crystal structures of GLUT5 from Rattus norvegicus in an open, outward-facing conformation and GLUT5 from Bos taurus in an open, inward-facing conformation; comparison of these structures with previously published structures of the related Escherichia coli d-xylose:H⁺ symporter XylE suggests that transport in GLUT5 is controlled by both a global ‘rocker-switch’-type motion and a local ‘gated-pore’-type transport mechanism.

Norimichi Nomura
Grégory Verdon
David Drew
Research30 Sept 2015
Nature

Volume: 526, P: 397-401
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Post-translational control of beige fat biogenesis by PRDM16 stabilization

The ubiquitin E3 ligase CUL2–APPBP2 determines PRDM16 protein stability by catalysing PRDM16 polyubiquitination in beige fat.

Qiang Wang
Huixia Li
Shingo Kajimura
ResearchOpen Access17 Aug 2022
Nature

Volume: 609, P: 151-158
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction

Epithelial cells can use an immune-like mechanism to extrude neighboring precancerous cells; however, the recognition and control mechanisms of this process are unclear. Maruyama and colleagues demonstrate that LILRB3 on normal epithelial cells recognizes elevated MHC class I on transformed cells and triggers the extrusion process.

Shiyu Ayukawa
Nagisa Kamoshita
Takeshi Maruyama
Research22 Oct 2021
Nature Immunology

Volume: 22, P: 1391-1402
Relationship between hearing thresholds and cognitive function in hearing aid non-users and long-term users post-midlife

Takanori Nishiyama
Tomomi Kimizuka
Naoki Oishi
ResearchOpen Access24 Feb 2025
npj Aging

Volume: 11, P: 1-7
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.

Yohei Abe
Yosuke Fujiwara
Juro Sakai
ResearchOpen Access19 Apr 2018
Nature Communications

Volume: 9, P: 1-16
Observational study of rebiopsy in EGFR-TKI-resistant patients with EGFR mutation-positive advanced NSCLC

Kenichi Koyama
Satoru Miura
Toshiaki Kikuchi
ResearchOpen Access16 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

Expression of Cas9 and gRNA from viral vectors in vivo may cause off-target activity. Here the authors present NanoMEDIC, which uses nanovesicles to transiently deliver editing machinery to hard-to-transfect cells.

Peter Gee
Mandy S. Y. Lung
Akitsu Hotta
ResearchOpen Access13 Mar 2020
Nature Communications

Volume: 11, P: 1-18
A phase II study of the safety of olanzapine for oxaliplatin based chemotherapy in coloraectal patients

Junichi Nishimura
Akiko Hasegawa
Masayuki Ohue
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-6
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS

Genes in the rodent brain are knocked down by DNA/RNA heteroduplexes injected intravenously.

Tetsuya Nagata
Chrissa A. Dwyer
Takanori Yokota
Research12 Aug 2021
Nature Biotechnology

Volume: 39, P: 1529-1536
Supercritical fluid flow through permeable window and phase transitions at volcanic brittle–ductile transition zone

The Kuju volcanic area’s shallow magma margin features a low-amplitude reflection zone that allows pressurized fluids to migrate upward, causing diverse earthquake clusters with complex mechanisms, according to analysis of magma-related and hydrothermal structures in the Kuju volcanic area in Japan.

Takeshi Tsuji
Rezkia Dewi Andajani
Haruhiro Inagaki
ResearchOpen Access24 Sept 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Prenatal diagnosis of haemophilia BM

Akira Yoshioka
Yoshiaki Ohkubo
Takeshi Matsuda
Research01 Dec 1988
Japanese journal of human genetics

Volume: 33, P: 395-400
Mitigating surface noise and attenuation in continuous monitoring of geologically stored CO₂ using a borehole portable active seismic source

Ahmad B. Ahmad
Takeshi Tsuji
Toru Sano
ResearchOpen Access14 Oct 2025
Scientific Reports

Volume: 15, P: 1-20
Effects of Chain Ends and Three-Segment Interactions on Second and Third Virial Coefficients of Four-Arm Star Polystyrenes

Yasuhiro Nishi
Yo Nakamura
Takeshi Norisuye
Research12 Nov 2008
Polymer Journal

Volume: 41, P: 58-62
Direct observation of potential phase at joining interface between p-MgO and n-MgFe₂O₄

Chisato Sakaguchi
Yasumasa Nara
Hiroshi Kubota
ResearchOpen Access13 Oct 2020
Scientific Reports

Volume: 10, P: 1-7
CO₂ oxidative coupling of methane using an earth-abundant CaO-based catalyst

Yongzheng Zhang
Yohei Cho
Takeshi Fujita
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7⁺ endosomes to the periphery of the cell via microtubule interactions, thus enabling pDC clustering and type I interferon production.

Shin-Ichiroh Saitoh
Fumiko Abe
Kensuke Miyake
ResearchOpen Access17 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Therapeutic effects of the PKR inhibitor C16 suppressing tumor proliferation and angiogenesis in hepatocellular carcinoma in vitro and in vivo

Takao Watanabe
Hiroko Ninomiya
Yoichi Hiasa
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Annual change in FEV₁ in elderly 10-year survivors with established chronic obstructive pulmonary disease

Masaru Suzuki
Hironi Makita
Masaharu Nishimura
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Freeze-Dried Platelet-Rich Plasma Accelerates Bone Union with Adequate Rigidity in Posterolateral Lumbar Fusion Surgery Model in Rats

Yasuhiro Shiga
Sumihisa Orita
Seiji Ohtori
ResearchOpen Access11 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Germline and somatic genetic changes in multicentric tumors obtained from a patient with multiple endocrine neoplasia type 1

Akane Naruoka
Sumiko Ohnami
Ken Yamaguchi
ResearchOpen Access27 Apr 2017
Human Genome Variation

Volume: 4, P: 1-6
High energy density rechargeable magnesium battery using earth-abundant and non-toxic elements

Yuki Orikasa
Titus Masese
Yoshiharu Uchimoto
ResearchOpen Access11 Jul 2014
Scientific Reports

Volume: 4, P: 1-6
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Satoshi Umemura
Hisatomi Arima
Nobuhito Hirawa
Reviews02 Aug 2019
Hypertension Research

Volume: 42, P: 1235-1481
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.

Hajime Abe
Norihiko Takeda
Issei Komuro
ResearchOpen Access27 Jun 2019
Nature Communications

Volume: 10, P: 1-10
The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes

Cryo-EM and X-ray crystal structures reveal the architecture of the human Xkr8–Basigin complex, providing insights into the molecular mechanism of phospholipid scrambling.

Takaharu Sakuragi
Ryuta Kanai
Shigekazu Nagata
ResearchOpen Access08 Oct 2021
Nature Structural & Molecular Biology

Volume: 28, P: 825-834
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

The microbiota of centenarians (aged 100 years and older) comprise gut microorganisms that are capable of generating unique secondary bile acids, including isoallolithocholic acid, a bile acid with potent antimicrobial effects against Gram-positive—but not Gram-negative—multidrug-resistant pathogens.

Yuko Sato
Koji Atarashi
Kenya Honda
Research29 Jul 2021
Nature

Volume: 599, P: 458-464
Robotic crowd biology with Maholo LabDroids

Nozomu Yachie
Koichi Takahashi
Tohru Natsume
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 310-312
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Critical roles of nardilysin in the maintenance of body temperature homoeostasis

The precise regulation of mammalian body temperature is important for survival. Here the authors show that the peptidase nardilysin represses the transcription factor PGC-1α, and identify nardilysin as a regulator of basal body temperature, cold-induced thermogenesis and body insulation.

Yoshinori Hiraoka
Tatsuhiko Matsuoka
Eiichiro Nishi
ResearchOpen Access04 Feb 2014
Nature Communications

Volume: 5, P: 1-11
Synthesis of a distinct water dimer inside fullerene C₇₀

Endohedral C₇₀ fullerenes containing either one or two water molecules have now been prepared using a molecular-surgery approach. The structure of H₂O@C₇₀ was determined by single-crystal X-ray analysis, revealing the encapsulated water molecule to be in an off-centre position. In (H₂O)₂@C₇₀, the two water molecules form a discrete dimer held together with a single hydrogen bond.

Rui Zhang
Michihisa Murata
Yasujiro Murata
Research07 Mar 2016
Nature Chemistry

Volume: 8, P: 435-441
Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support

Tae Higuchi
Tomomi Ide
Kohtaro Abe
ResearchOpen Access28 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Synthesis, Reactions, and Electrolyte Properties of Polymethacrylamides Having the L-threo-β-Hydroxyaspartic Acid Moiety

Fumio Sanda
Takashi Kurokawa
Takeshi Endo
Research01 Apr 1999
Polymer Journal

Volume: 31, P: 353-358
Grafting of Polymers onto Carbon Microcoil by Use of Carboxyl Groups on the Surface and Electric Properties of Conductive Composite Prepared from Silicone Rubber with the Polymer-Grafted Carbon Microcoil

Haruo Morohashi
Yukimune Takahashi
Seiji Motojima
Research12 Mar 2007
Polymer Journal

Volume: 39, P: 404-410
Antitumoral effects of defective herpes simplex virus-mediated transfer of tissue inhibitor of metalloproteinases-2 gene in malignant glioma U87 in vitro: Consequences for anti-cancer gene therapy

Michio Hoshi
Asako Harada
Takahito Yazaki
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 799-805
Effect of Coffee Intake on Blood Pressure in Male Habitual Alcohol Drinkers

Kazuo Funatsu
Takeshi Yamashita
Haruo Nakamura
Research01 Jun 2005
Hypertension Research

Volume: 28, P: 521-527
Smartphone application-based interventions for cardiometabolic risk factor management: A systematic review and meta-analysis

Makiko Abe
Tetsuo Hirata
Hisatomi Arima
Research03 Sept 2025
Hypertension Research

Volume: 49, P: 384-395
PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

Yusuke Okujima
Takao Watanabe
Yoichi Hiasa
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
PI3K/Akt pathway mediates the positive inotropic effects of insulin in Langendorff-perfused rat hearts

Yosuke Nakadate
Akiko Kawakami
Takashi Matsukawa
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-8
Host defense against oral microbiota by bone-damaging T cells

IL-17-producing T cells are protective against infection, but the authors of this article previously showed that these cells also contribute to inflammatory bone destruction. Here they show in the context of periodontitis that microbiota-driven Th17-mediated bone destruction may actually be a physiological rather than a pathological process, as associated tooth loss prevents dissemination of oral bacteria.

Masayuki Tsukasaki
Noriko Komatsu
Hiroshi Takayanagi
ResearchOpen Access16 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration

Nanami Kishima
Takashi Moriwaki
Yasuhiro Kazuki
ResearchOpen Access30 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Preparation and Characterization of Diblock Copolymers of the AB and CD Types and their Self-Assembled Structure by Hydrogen Bonding Interaction

Takeshi Asari
Shigeo Matsuo
Yushu Matsushita
Reviews15 Feb 2006
Polymer Journal

Volume: 38, P: 258-263
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution

Osteoclasts are the body’s exclusive bone-resorbing cells; however, their differentiation trajectory remains unclear. Using single-cell RNA sequencing, Tsukasaki et al. provide a comprehensive road map of osteoclastogenesis, unveiling stepwise molecular events underlying osteoclast cell fate transitions.

Masayuki Tsukasaki
Nam Cong-Nhat Huynh
Hiroshi Takayanagi
Research07 Dec 2020
Nature Metabolism

Volume: 2, P: 1382-1390
Chromosome position at the spindle equator is regulated by chromokinesin and a bipolar microtubule array

Jun Takagi
Takeshi Itabashi
Shin'ichi Ishiwata
ResearchOpen Access30 Sept 2013
Scientific Reports

Volume: 3, P: 1-7
Detection of quadratic phase coupling by cross-bicoherence and spectral Granger causality in bifrequencies interactions

Takeshi Abe
Yoshiyuki Asai
Alessandro E. P. Villa
ResearchOpen Access12 Apr 2024
Scientific Reports

Volume: 14, P: 1-15
Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate

Hiroyuki Satofuka
Yayan Wang
Yasuhiro Kazuki
ResearchOpen Access14 Mar 2023
Scientific Reports

Volume: 13, P: 1-11
Characterization of polychaetes inhabiting estuaries and inner bays by composition analysis of amino acids and lactate enantiomers

Mayu Onozato
Wataru Shinohara
Takeshi Fukushima
ResearchOpen Access06 Mar 2024
Scientific Reports

Volume: 14, P: 1-11

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