Nature Search

Brassinosteroid-induced gene repression requires specific and tight promoter binding of BIL1/BZR1 via DNA shape readout

BIL1/BZR1 upregulates some brassinosteroid-responsive genes and downregulates others. An integrated approach linking genome-wide analyses with biochemical and structural analyses elucidates the molecular basis of gene repression by BIL1/BZR1.

Shohei Nosaki
Nobutaka Mitsuda
Takuya Miyakawa
Research15 Dec 2022
Nature Plants

Volume: 8, P: 1440-1452
Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Laura K. M. Han
Willem B. Bruin
Moji Aghajani
ResearchOpen Access13 Jan 2026
Molecular Psychiatry

P: 1-16
Propagation of neuronal micronuclei regulates microglial characteristics

Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may act as mediators that control microglial characteristics.

Sarasa Yano
Natsu Asami
Fuminori Tsuruta
Research17 Jan 2025
Nature Neuroscience

Volume: 28, P: 487-498
Synthesis of Polyester Modified Silica Gel from Polymeric Tributylstannyl Ester of Silicic Acid and ε-Caprolactone

Osamu Moriya
Asami Matsui
Takeshi Endo
Research01 Jan 2000
Polymer Journal

Volume: 32, P: 82-86
Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling

Here, the triazole urea compound KK181N1 is identified as a Karrikin signaling-specific antagonist with a non-covalent binding mode, contrasting the covalent binding of the D14 antagonist KK094. This chemical tool holds potential in discriminating the KARs and SL signaling.

Jianwen Wang
Ikuo Takahashi
Tadao Asami
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-13
Correction: Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
Amendments and CorrectionsOpen Access20 Apr 2016
Nature Communications

Volume: 7, P: 1
Structure of the bile acid transporter and HBV receptor NTCP

Cryo-electron microscopy structures of the bile acid transporter NTCP in the apo state and in complex with the preS1 domain of hepatitis B virus (HBV) provide insight into NTCP substrate transport and HBV recognition mechanisms.

Jinta Asami
Kanako Terakado Kimura
Umeharu Ohto
Research17 May 2022
Nature

Volume: 606, P: 1021-1026
BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling

The authors identify BPG4, a novel regulator of chloroplast development. BPG4 directly suppresses transcriptional activity of GLK to fine-tune photosynthesis associated nuclear gene expression, and regulates chloroplast development and homeostasis.

Ryo Tachibana
Susumu Abe
Takeshi Nakano
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Structural basis for brassinosteroid response by BIL1/BZR1

The authors report the non-canonical crystal structure of the DNA binding domain from BIL1/BZR1, a transcription factor involved in brassinosteroid signalling, in complex with its target DNA fragment.

Shohei Nosaki
Takuya Miyakawa
Masaru Tanokura
Research01 Oct 2018
Nature Plants

Volume: 4, P: 771-776
Hepatitis B and D virus entry

In this Review, Watashi et al. explore hepatitis B virus and hepatitis D virus entry, focusing on the early phase driven by viral surface antigens and related host factors, highlight the role of viral entry in tropism and discuss the potential for drug development targeting this process.

Koichi Watashi
Kaho Shionoya
Takeshi Morita
Reviews21 Nov 2024
Nature Reviews Microbiology

Volume: 23, P: 318-331
Structure of Slitrk2–PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Atsushi Yamagata
Yusuke Sato
Shuya Fukai
ResearchOpen Access19 May 2015
Scientific Reports

Volume: 5, P: 1-6
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice

Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in development of social behaviour in mice.

Tomoyuki Yoshida
Atsushi Yamagata
Shuya Fukai
ResearchOpen Access23 Mar 2021
Nature Communications

Volume: 12, P: 1-15
Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ–IL1RAPL1/IL-1RAcP for synaptic differentiation

Synapse formation depends on trans-synaptic interactions between selective pairs of pre- and postsynaptic adhesion molecules. Here, the authors establish the basis for the splice isoform-dependent selectivity of receptor protein tyrosine phosphatase δ as it forms trans-synaptic contacts with IL1RAPL1 and IL-1RAcP.

Atsushi Yamagata
Tomoyuki Yoshida
Shuya Fukai
ResearchOpen Access24 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation

Synaptic organizers are cell adhesion molecules that facilitate synapse formation through trans-synaptic interactions. Here the authors give molecular insights into synaptic differentiation by determining the structures of the synaptic adhesion-like molecules SALM2 and SALM5 bound to the presynaptic organizer PTPδ.

Sakurako Goto-Ito
Atsushi Yamagata
Shuya Fukai
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-9
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice.

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-17
Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction

Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective binding of ligands to LRRTM1/2 is achieved.

Atsushi Yamagata
Sakurako Goto-Ito
Shuya Fukai
ResearchOpen Access27 Sept 2018
Nature Communications

Volume: 9, P: 1-11
Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

The study performed on a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.

Willem B. Bruin
Paul Zhutovsky
Moji Aghajani
Research10 Jan 2024
Nature Mental Health

Volume: 2, P: 104-118
Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

Mai Hatano
Waki Nakajima
Takuya Takahashi
ResearchOpen Access15 Oct 2024
Molecular Psychiatry

Volume: 30, P: 1780-1790
Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Hiroe Sato
Chinatsu Takai
Ichiei Narita
ResearchOpen Access18 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis

An automated amplification-free digital RNA detection platform using CRISPR-Cas13a and magnetic bead technology implemented in a microchamber device demonstrates sensitive SARS-CoV-2 genomic RNA detection and variant discrimination.

Hajime Shinoda
Tatsuya Iida
Rikiya Watanabe
ResearchOpen Access26 May 2022
Communications Biology

Volume: 5, P: 1-8
Amplification-free RNA detection with CRISPR–Cas13

The authors develop a platform (SATORI) that enables accurate and rapid detection of single-stranded RNA at a single-molecule level without a pre-amplification step. As a proof-of-concept, they demonstrate its utility in detecting the SARS-CoV-2 N gene at a minimum concentration of ~5 fM, which is much lower than other amplification-free CRISPR-Cas-based methods.

Hajime Shinoda
Yuya Taguchi
Rikiya Watanabe
ResearchOpen Access19 Apr 2021
Communications Biology

Volume: 4, P: 1-7
Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody

Ikumi Katano
Asami Hanazawa
Takeshi Takahashi
ResearchOpen Access26 Oct 2021
Scientific Reports

Volume: 11, P: 1-13
Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization

Rie Murayama
Mariko Kimura-Asami
Hidehito Kuroyanagi
ResearchOpen Access12 Jun 2018
Scientific Reports

Volume: 8, P: 1-14
Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

Hirohiko Kohjitani
Shigeya Koda
Takeshi Kimura
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-16
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation

Ayumi Yamagami
Chieko Saito
Takeshi Nakano
ResearchOpen Access18 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases

Hiroki Kaneko
Kei Takayama
Hiroko Terasaki
ResearchOpen Access25 May 2017
Scientific Reports

Volume: 7, P: 1-9
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients

Takanobu Iwadare
Takefumi Kimura
Takeji Umemura
ResearchOpen Access07 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Development of an intraoperative breast cancer margin assessment method using quantitative fluorescence measurements

Hiroki Ueo
Itsushi Minoura
Koshi Mimori
ResearchOpen Access20 May 2022
Scientific Reports

Volume: 12, P: 1-10
Development of thermoplastic films via formulation design technology for millimeter-wave communication applications

This focus review describes two types of thermoplastic films developed via formulation design technology for mmWave communication. The first type is a crystalline polyaryletherketone (PAEK)-based film, which is improved with plate-like fillers and miscible noncrystalline polymers. This film exhibits low dielectric properties, heat resistance, low thermal expansion, and excellent multilayer processing capabilities. The second type is a specialized polyolefin resin-based film, which achieves ultralow dielectric properties comparable to those of PTFE and combines excellent copper adhesion with customizable functionalities such as laser processability, transparency, and flame retardancy.

Seigo Suzuki
Reviews25 Sept 2024
Polymer Journal

Volume: 57, P: 69-77

Search

Brassinosteroid-induced gene repression requires specific and tight promoter binding of BIL1/BZR1 via DNA shape readout

Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Propagation of neuronal micronuclei regulates microglial characteristics

Synthesis of Polyester Modified Silica Gel from Polymeric Tributylstannyl Ester of Silicic Acid and ε-Caprolactone

Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling

Correction: Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Structure of the bile acid transporter and HBV receptor NTCP

BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling

Structural basis for brassinosteroid response by BIL1/BZR1

Hepatitis B and D virus entry

Structure of Slitrk2–PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice

Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ–IL1RAPL1/IL-1RAcP for synaptic differentiation

Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction

Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis

Amplification-free RNA detection with CRISPR–Cas13

Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody

Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization

Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation

Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients

Development of an intraoperative breast cancer margin assessment method using quantitative fluorescence measurements

Development of thermoplastic films via formulation design technology for millimeter-wave communication applications

Search

Quick links

Search

Filter By:

Search

Quick links