In Drosophila, larval neural circuits are remodeled during metamorphosis by both pruning and neurite remodeling, which requires TGF-β signaling. Here, Awasaki and colleagues find that glia secrete myoglianin, a TGF-β ligand, which upregulates neuronal expression of an ecdysone nuclear receptor that triggers neurite remodeling following the late-larval ecdysone peak.
- Takeshi Awasaki
- Yaling Huang
- Tzumin Lee
