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The authors develop textile electronic substrates with tailored stiffness and interfacial affinities by selective and controllable laser-matter interaction, addressing the mechanical mismatch between hybrid electronics and elastic textiles.

Cryogenic electron tomography suffers from anisotropic resolution due to the missing-wedge problem. Here, the authors present IsoNet, a neural network that learn the feature representation from similar structures in the tomogram and recover the missing information for isotropic tomogram reconstruction.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Animals find and stay close to resources by altering their locomotion in response to odors that signal resources. Here the authors identify, using Drosophila locomotion in response to odor, a simple strategy that adapts its motor program to sensory context automatically.

Authors in this study discover a CCKBR agonist MF-8 with β-arrestin bias. This biased agonist can reduce other CCKBR signaling pathways, including Gαs-induced cAMP and Gαq/11-induced calcium signaling, thereby inhibiting the CCKBR-LTP. This discovery provides us with new ideas for developing drugs targeting CCKBR.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

δ-Opioid receptors (δOR) are promising targets for pain management with reduced side effects. Here, the authors use a structure-based approach to design and characterize C6-Quino, a selective δOR partial agonist, highlighting its potential therapeutic relevance.

Nanopores are an emerging powerful single-molecule method of DNA sequencing. Here the authors map the structure of aerolysin for use as a nanopore and show detection of modified and unmodified nucleobases.

Arabidopsis thaliana PIN3 structures reveal the molecular mechanisms of the transport of indole-3-acetic acid and the inhibition of polar auxin transport by N-1-naphthylphthalamic acid.

Sun, Tao, Han et al. identify the Rabs involved in unconventional protein secretion mediated by TMED10 and in ER–Golgi intermediate compartment organization.

This study reports the development and preclinical evaluation of a humanized citrullinated histone H3 (CitH3) monoclonal antibody that mitigates inflammation, restores macrophage function, and protects against sepsis-induced pulmonary injury.

Active-state structures of the κ-opioid receptor in complexes with the G-protein heterotrimers G_i1, G_oA, G_z and G_g provide insights into the actions of hallucinogenic opioids and G-protein-coupling specificity at the κ-opioid receptor.

Geometric quantum gates—engineered evolution paths for qubit control—promise noise resilience but have shown limited fidelity in prior implementations in semiconductor quantum computation. Here the authors demonstrate high-fidelity single-qubit gates in a single-hole quantum dot in Ge, outperforming conventional dynamical gates.

A newly discovered negative allosteric modulator of the µ-opioid receptor works together with naloxone to potently block opioid agonist signalling with reduced adverse effects.

Membrane proteins play essential roles in biological processes but are very difficult to study due to their hydrophobic nature. Here, the authors apply the QTY code, a method for designing water soluble membrane proteins, to histidine kinase CpxA to render it completely water-soluble and preserve the native molecular function.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

In this clinical trial, the authors demonstrate that recombinant gE-Fc Fusion Protein Vaccine LZ901 for herpes zoster induces superior cellular immunogenicity and exhibits a better safety profile than HZ/su in adults ≥50 years, supporting its potential as vaccine candidate.

Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation.

Kra-Dai language family exhibits great linguistic diversity and tremendous socio-cultural importance in East Asia. In this study, the authors found that Kra-Dai languages initially diverged ~4,000 years ago in Southern China coinciding with prehistoric demic and agricultural diffusions likely driven by climate change.

Dimension reduction (DR) is a key step of Cytometry by Time-of-Flight (CyTOF) data analysis. Here, the authors benchmark 21 DR methods on 110 real and 425 synthetic CyTOF samples, finding a high level of complementarity between the methods, and providing a comprehensive set of user guidelines.

Xu et al. report structures of the Arabidopsis cytokinin importer AZG1 in the apo, trans-zeatin-bound, 6-benzyleaminopurine-bound and kinetin-bound states, and elucidate an elevator transport model for the AZG1-mediated cytokinin uptake.

This Article reports cross-linking mass spectrometry (XL-MS) standard datasets with fully controlled protein interactions that are an order of magnitude more complex than existing ones. These datasets are used to benchmark XL-MS software and establish a fast, error-controlled search tool for XL-MS with cleavable reagents.

Cryo-electron microscopy structures of three adhesion G protein-coupled receptors (aGPCRs) complexes provide insight into the tethered activation mechanism of aGPCRs and show the potential for rational design of agonists.

The authors report on the structure of a glucocorticoid-bound adhesion G-protein-coupled receptor–G protein complex.

Optogenetic tools allowing transcranial neural inhibition in treating seizures are limited. This study demonstrates that noninvasive transcranial optogenetic activation of a highly sensitive K + -conductive channelrhodopsin (HcKCR1-hs) silences neurons and suppresses seizures deep in the brain, alleviating epilepsy symptoms in mouse models, without intracranial surgery.

mRNA modifications like m⁵C are typically introduced by tRNA-modifying enzymes, while the catalytic mechanism and function remain debated. Here, the authors show that NSUN6 catalyzes tRNA and mRNA substrates in different ways, and that NSUN6 promotes breast cancer cell migration through mRNA m⁵C modification.

The structural flexibility of langbeinite-type structures to host different cations makes them suitable candidates for the formation of multicomponent actinide nuclear waste forms, but this approach remains underexplored. Here, the authors use an optimized high-temperature molten salt method to synthesize a series of single crystals of Cs₂U^ⅣLn(PO₄)₃ (Ln = Ce – Nd and Sm – Lu) that can simultaneously immobilize U, Ln, and Cs with enhanced leaching resistance.

Socioeconomic status has been previously linked to cancer outcomes. Here, the authors use an umbrella review to identify differences in access to immunotherapy and cancer screening.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

A thin elastic conductive nanocomposite that is formed by cryogenically transferring laser-induced graphene to a hydrogel film can be used to create multifunctional sensors for on-skin monitoring and cardiac patches for in vivo detection.

Quantum simulations of topological matter with superconducting qubits have been attracting attention recently. Xiang et al. realize 2D and bilayer Chern insulators with synthetic dimensions on a programmable 30-qubit-ladder superconducting processor, showing bulk-boundary correspondence.

The description of the cryo-EM structure of an orphan adhesion GPCR–G_s protein complex in apo state facilitates the screening and identification of potential ligands of ADGRG2.

Cryo-EM has facilitated structural studies of membrane proteins, but inactive GPCRs have remained inaccessible due to their small size. Robertson et al. demonstrate a common nanobody-based approach to streamline the determination of such structures.

Cryo-electron microscopy structures of human Porcupine in complex with palmitoleoyl-coenzyme A, the inhibitor LGK974 and its peptide substrate suggest a mechanism for Wnt acylation.

Particulate methane monooxygenase (pMMO) is the main enzyme used by methanotrophs. Here, the authors determined the native structure of pMMO by cryo-electron tomography, revealing lipid-stabilized features and a higher-order hexagonal array arrangement in intact cells.