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Drugs that rescue function of episodic ataxia 1 (EA1) mutant potassium channels are lacking. Here, Manville et al identify and describe the molecular basis for Native American botanical ataxia remedies that directly rescue EA1 mutant channels.

How inflammation spreads from the skin to the joints in psoriatic disease is unclear. Here, the authors show that joint-resident fibroblasts can control differentiation of infiltrating skin-derived myeloid precursors that can become inflammatory macrophages.

This study shows that, by age 4, children understand lexical causatives to refer to direct causes and periphrastic causatives to indirect causes in causal chains. Understanding causation by absence develops later in older children.

Scientists disagree about area-based conservation’s role in addressing biodiversity loss. This Perspective examines how conservation scientists, land systems scientists and political ecologists approach these debates differently and argues that environmental data justice frameworks can bridge epistemic divides, helping researchers to develop more effective and equitable conservation interventions.

Elaborate traits like birdsong are thought to be sexually selected in males but are poorly understood in females. This study shows that year-round territoriality and biparental care are selected for female birdsong, whereas migration, seasonal territoriality, and loss of male care led to losses of female song.

This prospective cohort study of patients with cancer incorporated antemortem follow-up visits and rapid autopsy analyses, and reports that spikes—rapidly increasing levels—of circulating tumor cell clusters, observed immediately before and at the time of death, along with tumor masses infiltrating large vessels, were cancer-related events associated with patient mortality.

Metal-organic frameworks (MOFs) have potential catalysis, filtration and sensing applications, but device fabrication will require controlled MOF growth. Here, α-hopeite microparticles are used to achieve spatial control of MOF nucleation, and accelerate MOF growth.

Experience-dependent plasticity in the visual system has widely been considered to be exclusively cortical. Using chronic two-photon Ca²⁺imaging of individual thalamic boutons, Jaepel et al. now report that dLGN cells projecting to mouse visual cortex show pronounced ocular dominance plasticity after monocular deprivation.

The NV center in diamond has been used extensively in sensing; however single shot readout of its spin remains challenging, requiring complex optical setups. Here, Irber et al. demonstrate a more robust scheme that achieves single-shot readout even when using inefficient detection optics.

The study introduces scFFPE-ATAC, a high-throughput single-cell chromatin accessibility profiling method enabling profiling from clinically archived formalin-fixed paraffin-embedded (FFPE) tissues, unlocking retrospective epigenetic insights across cancer and human diseases.

Ammonium levels in Greenland ice cores track changes in soil emissions and wildfires, primarily in North America. Ice-core ammonium records show abrupt increases in wildfire activity during brief warmings in the last glacial period.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Locityper is a general-purpose genotyper that can efficiently genotype and analyze a diverse set of genes, such as hyperpolymorphic HLA genes, using both short-read and long-read whole-genome sequencing data.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Observation of glioblastoma invasion in subcortical brain regions is challenging. Here the authors develop a Deep3P workflow to enable longitudinal deep imaging of glioblastoma and its microenvironment by combining three-photon microscopy and deep learning-based analysis, unraveling the invasion routes of these tumor cells into and within the white matter.

The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

Analysis of CDK and ERK signaling activities by live- and fixed-cell microscopy assays during adipogenesis provides a mechanistic understanding of sequential events that link permanent cell cycle arrest to terminal cell differentiation.

Guiding the assembly pathway of a nanoparticle system toward multiple superstructures while visualizing in situ remains challenging. Here the authors combine liquid-cell transmission electron microscopy, scaling theory and molecular dynamics simulations to image and quantify self-assembly processes of gold nanocubes into distinct superlattices.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Neural mechanisms underlying representational drift are not fully understood. Here authors report that the preferred orientation of mouse visual cortex neurons drifts over time. Altering visual experience does not change drift magnitude, but rather its direction, such that neurons’ tuning matches the statistics of the environment.

Bradyzoites are a quiescent form of Toxoplasma gondii enclosed in cysts during chronic infections. Here, Christiansen et al. develop a human myotube-based in vitro culture model of cysts that are infectious to mice and characterize their metabolism in comparison to fast replicating tachyzoites.

Hayer et al. observe that collectively migrating endothelial cells extend rear VE-cadherin-rich membrane structures that are engulfed by follower cells, correlating spatially with the direction of movement.

Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development for wing evolution.

Ice-shelf grounding lines off the coast of Antarctica have retreated over the past 20,000 years. Precise dating of moraines suggests the timing of retreat in the Ross Sea was controlled by the interplay between accumulation and ocean forcing.

Targeted nanodrug delivery is crucial to treat respiratory diseases, but profiling the delivery and dynamics of nanoparticles (NPs) within the lung is a challenging task. Here, the authors present LungVis 1.0, an AI-driven 3D imaging ecosystem to profile inhaled substances in distinct lung regions while uncovering the role of tissue-resident macrophages in the fate of NPs.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

High-elevation meteorological observations and reanalysis data indicate local cooling and drying near Himalayan glaciers due to enhanced katabatic winds in response to global warming.

The DANIO-CODE consortium leverages a large-scale multiomic dataset to improve zebrafish genome annotation. They identify ~140,000 cis-regulatory elements throughout development and perform a comparison with the mouse regulatory landscape.

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Depletion of RNA polymerase II pausing and elongation factor Spt5 in B cells indicates that ~50% of enhancer–gene pairs show co-regulated transcription. CRISPRa-mediated rescue of enhancer transcription in Spt5-depleted cells restores Igh gene expression.

Tropical deforestation rates are linked to large-scale land investments, according to georeferenced land deal records and remote sensing of forest loss over the past two decades.

Fast temporal dynamics of the olfactory environment can be perceived by mice and used to perform scene segmentation.

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

SLAM seq detects s⁴U incorporation into RNA and, combined with 3′-end RNA-seq, provides insight into RNA turnover.

Successful cancer immune therapy correlates with a T cell-inflamed tumour microenvironment. Authors show here that co-administration of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus in an optimised regimen strongly enhances T cell immunogenicity and may turn non-inflamed tumours proinflammatory and less resistant to checkpoint blockade therapy.

Possible effects of weather conditions on COVID-19 transmission are debated. Here, the authors analyse data from early in the pandemic and show that although temperature and humidity had small effects on transmission, they were far out-weighed by the effects of non-pharmaceutical interventions.

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

The CCR4–NOT deadenylase complex has a crucial role in post-transcriptional mRNA regulation, catalyzing the removal of mRNA poly(A) tails and consequently repressing translation and promoting mRNA degradation. The crystal structure of the human NOT module, formed by the CNOT1, CNOT2 and CNOT3 C-terminal regions, now provides a structural framework for understanding its assembly and functions.

Insight, involving representational change, can boost long-term memory. Here, in an fMRI study, the authors show that insight triggers stronger conceptual shifts in solution relevant brain regions and enhanced network integration, improving memory retention.

A thermophoretic trapping approach enables users to observe the behavior of single amyloid fibrils in solution for hours without any immobilization.

A massive galaxy hosting an accreting supermassive black hole two billion years after the Big Bang shows fast neutral-gas outflows that are capable of stopping star formation by removing its fuel while the stars keep rotating in a disk.