GTP-binding protein 1 (GTPBP1) is GTPase closely related to elongation factor eEF1A, but the GTPBP1-mediated elongation is slow. Here, the authors show how the distinct GTPBP1 architecture leads to slow dissociation, delayed tRNA accommodation, an extended proofreading stage and higher accuracy of GTPBP1-mediated decoding.
- Denis Susorov
- Anna Miścicka
- Andrei A. Korostelev
