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Host factor that restrain viral propagation offer new anti-RNA virus strategies. Here the authors provide evidence that endonuclease G (ENDOG) is a host anti-viral factor and engineer ENDOG expression on the mitochondrial outer membrane to eliminate viral RNA.

The substrate surface engineering approach prevents the formation of twin structures, while the elimination of twins greatly enhances carrier mobility and suppresses bipolar conduction, leading to optimized power factor in twin-free Bi₂Te₃ films.

Four-dimensional printing methods are promising for soft actuators, but existing methods limit programmable molecular alignment to two dimensions. Here the authors report a diffusion-guided two-photon polymerization strategy achieving true volumetric 3D microprinting of liquid crystal network microactuators, enabling complex actuation.

Single-cell multi-omics integration across gene expression, protein abundance and chromatin accessibility remains challenging. The authors present scMAGCA, an interpretable framework for integrating these modalities, and apply it to Alzheimer’s disease and kidney cancer to identify disease-associated cell states and biomarkers.

ADAR1, an RNA-editing enzyme, can contribute to immunotherapy resistance by suppressing interferon signaling. This study shows that all-trans retinoic acid (ATRA) promotes ADAR1 degradation, supporting ATRA combined with PD-L1 blockade as a potential therapeutic strategy.

Authors develop an autonomous agentic LLM called DxDirector-7B. Its clinical diagnostic accuracy outperforms larger models. Using deep thinking strategies, it significantly reduces physician workload, requesting human assistance only when necessary.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

A randomised trial in metformin-treated type 2 diabetes found once-weekly efsubaglutide improved HbA1c and fasting glucose, reduced weight, and enhanced meal-stimulated insulin secretion with mainly mild GI side effects.

This study reports a highly flexoelectric organic-inorganic hybrid material for uranium removal from wastewater. The work identifies key factors governing flexocatalytic capacity and offers insights for uranium recovery and environmental remediation.

Strain-resilient, self-healing conductors are needed for wireless e-skin but usually face a trade-off between conductivity and flexibility. Hou et al. design a polymer-based conductor with ultralow sheet resistance and use it to build a high-performance, self-healing flexible antenna.

Tracing the origins of lithium dendrite growth remains a critical challenge for lithium metal batteries. Here, the authors introduce an interfacial excess charge distribution factor to understand lithium dendrite growth, guiding the design of an electrolyte that suppresses Li dendrites in practical pouch cells.

Previous studies of vortex Majorana zero modes (MZMs) in iron-based superconductors have predominantly considered the case where magnetic field is parallel to the Dirac axis. Here, the authors focus on vortices oriented perpendicular to the Dirac axis, finding that such vortices are more favorable for observing vortex MZMs.

In a multicentre trial of AAV1-hOTOF gene therapy involving 42 participants aged 0.8–32.3 years with autosomal recessive deafness 9, treatment demonstrated safety, tolerability, and improved hearing and speech perception, with age and distortion product otoacoustic emissions associated with treatment outcomes.

Solitons are ubiquitous phenomena, yet controlling both propagation and localization in thermal fields is challenging. Here, the authors demonstrate thermal and heat solitons in electronically driven thermoelectric metamaterials, based on the interplay of non-Hermitian and thermal features.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions

Recycling polycarbonate plastics is energy intensive and depends on excess methanol. This work couples plastic breakdown with glycerol conversion to regenerate methanol in situ, reducing energy use while achieving high yields at pilot scale.

Here, the authors identify ten morphogroups of dermal denticles across extant shark species and quantify their mechanical properties and material composition alongside swimming performance, linking these traits to distinct ecological niches.

CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection

Authors propose a triple-synergy strategy for dielectric ceramics that integrates medium-entropy superparaelectric design, local structural distortion and plate-like BiTO phase construction, thereby achieving remarkable energy storage performance.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

The authors report associations of social isolations and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioral phenotypes among UK Biobank participants.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Here authors demonstrate that ion transport in acceptor-doped melilite solid electrolytes is driven by interstitial cation migration rather than oxygen vacancies, revising the defect chemistry of this important family of energy materials.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Researchers show that additive manufacturing can create high-density stable edge dislocations in a refractory high-entropy alloy, enabling unusually strong yet ductile performance at high temperatures and providing a new route to extreme-environment materials.

Here, the authors show that differential expression benchmarking for microbial community gene expression (metatranscriptomics) using cultured mock community samples as well as metatranscriptomes from humans and gnotobiotic animals improves inference of metabolic strategies.

A high-entropy strategy combines flattened electronic bands, core–shell microstructures, and polymorphic polar phases to overcome the trade-off between polarization and breakdown electric field, achieving high energy storage performance in lead-free dielectric ceramics.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

The surface chemical ordering in high entropy alloys is revealed by the surface sensitive imaging tool - scanning tunneling microscopy – which is enabled by the subtle differences in the partial density of states among different elements.

By developing frequency locking and time synchronization between independent ultrastable lasers and atomic clocks, twin-field quantum key distribution is demonstrated over 14.2-km turbulent free-space channels, with a secure key rate exceeding the repeaterless capacity bound.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Flexible batteries often fail under harsh conditions. Here, authors developed a hydrogel electrolyte via synergism of nanophase separation, hydrated eutectic solvation, and hydrogen-bond networks, enabling flexible Zn||I₂ batteries with high specific energy and long lifespan across −40 to 80 °C.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Organic solar cells need acceptor molecules with long exciton diffusion lengths, but most available materials fail in thick films. The authors design new fluorinated quinoxaline acceptors that significantly improve carrier mobilities resulting in superior efficiency in both binary and ternary devices.

Quantum error correction is essential for reliable quantum computing, but standard codes are usually designed for generic noise and may perform poorly on real devices. Here, the authors introduce a variational graphical framework that tunes known codes to device-specific noise, improving performance in simulations and photonic experiments.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Improvements in the Articulate Medical Intelligence Explorer, a large language model designed for diagnostic dialogue, enable the model to request, interpret and reason about multimodal medical data.

Hu et al. show that the transmembrane glycoprotein CD98hc in cerebral endothelial cells regulates the integrin–FAK signaling pathway, thereby promoting angiogenesis and maintaining blood–brain barrier integrity.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Part of the Hong Kong Genome Project, genomic analyses of more than 20,000 participants provide information on clinically relevant variants for the Chinese population and offer insights on the implementation of genomic medicine initiatives.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.