Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
2D association and integrative omics analysis in rice provides systems biology view in trait analysis

Wenchao Zhang et al. developed a tool for analyzing traits using data generated from genome-wide, transcriptome-wide, and metabolome-wide association studies. They test their approach in rice, providing a systems biology view of identified traits.

Wenchao Zhang
Xinbin Dai
Patrick X. Zhao
ResearchOpen Access27 Sept 2018
Communications Biology

Volume: 1, P: 1-14
Multimodal fusion of radio-pathology and proteogenomics identify integrated glioma subtypes with prognostic and therapeutic opportunities

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

Zaoqu Liu
Yushuai Wu
Zhenyu Zhang
ResearchOpen Access13 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Electrocatalytic reduction of CO₂ to ethylene and ethanol through hydrogen-assisted C–C coupling over fluorine-modified copper

Electrocatalytic reduction of CO₂ into multicarbon (C₂₊) products is a highly attractive route for CO₂ utilization. Now, a fluorine-modified copper catalyst is shown to achieve current densities of 1.6 A cm⁻² with a C₂₊ Faradaic efficiency of 80% for electrocatalytic CO₂ reduction in a flow cell.

Wenchao Ma
Shunji Xie
Ye Wang
Research20 Apr 2020
Nature Catalysis

Volume: 3, P: 478-487
Coherent steering of nonlinear chiral valley photons with a synthetic Au–WS₂ metasurface

By entangling the phase and spin of light, a synthetic metasurface is shown to be able to coherently manipulate the valley-exciton-locked chiral emission in monolayer tungsten disulfide at room temperature. The findings will be of benefit to advanced room-temperature and free-space nonlinear, quantum and valleytronic nanodevices.

Guangwei Hu
Xuanmiao Hong
Cheng-Wei Qiu
Research01 Apr 2019
Nature Photonics

Volume: 13, P: 467-472
Neuropathologist-level integrated classification of adult-type diffuse gliomas using deep learning from whole-slide pathological images

Determining glioma types directly from whole-slide images (WSIs) would be of great diagnostic utility. Here, the authors develop a deep learning model to identify diffuse glioma types from WSIs according to the 2021 WHO classification across multiple cohorts and with interpretable features.

Weiwei Wang
Yuanshen Zhao
Zhenyu Zhang
ResearchOpen Access11 Oct 2023
Nature Communications

Volume: 14, P: 1-11
Promoting electrocatalytic CO₂ reduction to formate via sulfur-boosting water activation on indium surfaces

CO₂ conversion to liquid fuels provides an appealing means to remove the greenhouse gas, although it is challenging to find materials that are both active and selective. Here, authors show sulfur-doped indium to be a highly active and selective electrocatalyst that transforms CO₂ into formate.

Wenchao Ma
Shunji Xie
Ye Wang
ResearchOpen Access21 Feb 2019
Nature Communications

Volume: 10, P: 1-10
Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial

In a phase 1b/2a trial, the combination of the oral PI3K inhibitor duvelisib and romidepsin had limited toxicity and exhibited encouraging clinical activity in patients with relapsed or refractory T cell lymphoma, suggesting an approach whereby PI3K inhibitors can be safely used in this patient population.

Steven M. Horwitz
Ajit J. Nirmal
Santosha A. Vardhana
Research17 Jun 2024
Nature Medicine

Volume: 30, P: 2517-2527
The elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice

The study identifies transcription factor OsGATA8 as a negative regulator of nitrogen uptake and tiller formation in rice and OsGATA8-H as an elite haplotype with reduced expression and enhanced nitrogen use efficiency.

Wei Wu
Xiaoou Dong
Jianmin Wan
ResearchOpen Access13 Jun 2024
Nature Genetics

Volume: 56, P: 1516-1526
Effect of external infusion connection devices replacement frequency on catheter related bloodstream infection

Wenchao Wang
Yuqing Wang
Ying Gu
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-8
Correlation analysis between RAS gene mutations and pathological morphological features in colorectal cancer

Lili Guo
Yifei Wang
Shuai Wang
ResearchOpen Access09 Dec 2025
Scientific Reports

Volume: 15, P: 1-12
Scalable synthesis of hierarchically structured carbon nanotube–graphene fibres for capacitive energy storage

Hierarchical hybrid carbon fibres consisting of a network of nitrogen-doped reduced graphene oxide and single-walled carbon nanotubes are synthesized and subsequently used to make a supercapacitor with high volumetric energy density.

Dingshan Yu
Kunli Goh
Yuan Chen
Research11 May 2014
Nature Nanotechnology

Volume: 9, P: 555-562
Association of serum and aqueous humor myonectin concentrations with diabetic retinopathy

Huibo Sun
Zhongtao Li
Wenjie Ma
ResearchOpen Access30 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
Universal inter-molecular radical transfer reactions on metal surfaces

Radicals are expected to be inactive on metal surfaces. Here the authors describe general intermolecular radical transfer reactions on Ag and Cu surfaces and confirm the reaction mechanism by extensive control experiments.

Junbo Wang
Kaifeng Niu
Lifeng Chi
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-10
Molecular-level insight into photocatalytic CO₂ reduction with H₂O over Au nanoparticles by interband transitions

While plasmonic metals show some activity for photocatalysis, they often must be paired with semiconductors or sacrificial reagents. Here, authors find quantum-sized Au nanoparticles can achieve photocatalytic CO₂-to-CO conversion with H₂O by charge carriers generated from interband transitions.

Wenchao Shangguan
Qing Liu
Jincai Zhao
ResearchOpen Access06 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Frailty-related plasma metabolomic signatures predict long-term mortality risk and implicate systemic aging pathways: evidence from a prospective cohort study

Xiru Zhang
Xin Feng
Chuanzhi Duan
ResearchOpen Access13 Jan 2026
npj Aging

Volume: 12, P: 1-15
Stimulant medications in children with ADHD normalize the structure of brain regions associated with attention and reward

Feifei Wu
Wenchao Zhang
Yi Zhang
Research26 Feb 2024
Neuropsychopharmacology

Volume: 49, P: 1330-1340
Enhancing piezoelectric coefficient and thermal stability in lead-free piezoceramics: insights at the atomic-scale

The authors reveal that the incorporation of doping elements with varying electronic structures and ionic radii alters the atomic-scale configuration, thereby affecting the local energy barrier associated with polarization rotation.

Jinzhu Zou
Miao Song
Shujun Zhang
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-9
Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

The gut commensal Parabacteroides distasonis uses inulin to produce the odd-chain fatty acid pentadecanoic acid, which alleviates non-alcoholic steatohepatitis via improved barrier function in mice.

Wenchao Wei
Chi Chun Wong
Jun Yu
ResearchOpen Access29 Jun 2023
Nature Microbiology

Volume: 8, P: 1534-1548
Genome-wide association studies identify OsWRKY53 as a key regulator of salt tolerance in rice

Only a few genetic variants have been identified to mediate salt tolerance in major crops and their molecular mechanisms are largely unknown. Here, the authors identify WRKY53 as a negative regulator of salt tolerance in rice, and show that it directly trans-regulates expression of MKK10.2 and HKT1;5 to meditate salt tolerance.

Jun Yu
Chengsong Zhu
Jianmin Wan
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Changes in the epidemiological characteristics of prehospital emergency services before and during the COVID-19 pandemic, Chengdu, 2016–2021

Bihua Zhang
Wenchao Kang
Tao Xiang
ResearchOpen Access13 May 2023
Scientific Reports

Volume: 13, P: 1-8
Enabling low voltage losses and high photocurrent in fullerene-free organic photovoltaics

Improving the power conversion efficiency is the main target of the organic solar cell research. Here Yuan et al. develop unconventional electron-deficient-core-based non-fullerene acceptors to achieve both low voltage loss and high current density, leading to a certified high efficiency of 12.6%.

Jun Yuan
Tianyi Huang
Yang Yang
ResearchOpen Access04 Feb 2019
Nature Communications

Volume: 10, P: 1-8
Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment

Gan Liu
Xinfeng Yao
Zongcheng Yang
ResearchOpen Access18 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-18
Predicting 1p/19q co-deletion status from magnetic resonance imaging using deep learning in adult-type diffuse lower-grade gliomas: a discovery and validation study

The authors developed a deep learning model predictive of 1p/19q status from preoperative imaging in 555 lower-grade gliomas (LGG), and achieved an area under the curve (AUC) of 0.983 in the testing dataset. They reveal that developing deep learning imaging signatures could be a noninvasive tool for predicting molecular markers in LGG.

Jing Yan
Shenghai Zhang
Zhenyu Zhang
Research15 Nov 2021
Laboratory Investigation

Volume: 102, P: 154-159
Development and validation of a motivation scale for deep vein thrombosis prophylaxis in postdischarge hip and knee arthroplasty patients

Feng Fu
Xiurui Deng
Yinglan Li
ResearchOpen Access11 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
Evaluate lymphovascular space invasion in endometrial cancer using diffusion-weighted imaging-based habitat imaging

Wei Wang
Junlan Lang
Mengchao Zhang
ResearchOpen Access11 Dec 2025
Scientific Reports

Volume: 16, P: 1-11
Plasmonic silver quantum dots coupled with hierarchical TiO₂ nanotube arrays photoelectrodes for efficient visible-light photoelectrocatalytic hydrogen evolution

Zichao Lian
Wenchao Wang
Hexing Li
ResearchOpen Access12 Jun 2015
Scientific Reports

Volume: 5, P: 1-10
Applying large language models for automated essay scoring for non-native Japanese

Wenchao Li
Haitao Liu
ResearchOpen Access03 Jun 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-15
An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer

Mengjie Chen
Cheng Zou
Dingxiao Zhang
Research02 Apr 2024
Oncogene

Volume: 43, P: 1594-1607
A multi modal fusion coal gangue recognition method based on IBWO-CNN-LSTM

Wenchao Hao
Haiyan Jiang
Shirong Sun
ResearchOpen Access05 Dec 2024
Scientific Reports

Volume: 14, P: 1-21
Development of insect life tables: comparison of two demographic methods of Delia antiqua (Diptera: Anthomyiidae) on different hosts

Shuoying Ning
Wenchao Zhang
Jinian Feng
ResearchOpen Access06 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Dynamics of chromatin accessibility governing Gd-IgA1 synthesis in B cells associated with IgA nephropathy

Yangang Gan
Jiajia Li
Qiongqiong Yang
ResearchOpen Access23 Jul 2025
Experimental & Molecular Medicine

Volume: 57, P: 1593-1606
Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas

Lei Wang
Wenchao Gu
Lan Zhou
ResearchOpen Access25 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation

Yuting Liu
Wenchao Hu
Jun Yan
ResearchOpen Access24 Jun 2013
Scientific Reports

Volume: 3, P: 1-11
Cooperative blockade of FLT3 and ALK synergistically suppresses growth of osteosarcoma

Wenchao Zhang
Lin Qi
Zhihong Li
Research19 Nov 2024
Oncogene

Volume: 44, P: 427-438
Research on the timing for subsequent water flooding in Alkali-Surfactant-Polymer flooding in Daqing Oilfield based on automated machine learning

Wenchao Jiang
Zhaowei Hou
Lei Zhang
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Changes in and significance of platelet function and parameters in Kawasaki disease

Xiaolan Zheng
Wenchao Wu
Gang Wu
ResearchOpen Access27 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
Exploring genetic alterations in circulating tumor DNA from cerebrospinal fluid of pediatric medulloblastoma

Yanling Sun
Miao Li
Yongji Tian
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Exploring physiological stress response evoked by passive translational acceleration in healthy adults: a pilot study utilizing electrodermal activity and heart rate variability measurements

Xiaoru Yu
JiaWei Lu
Gang Xiao
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-9
Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China

Yin-Shan Wang
Xue-Ting Su
Xi-Nian Zuo
ResearchOpen Access07 May 2024
Scientific Data

Volume: 11, P: 1-17
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
Influence of rootstock on endogenous hormones and color change in Cabernet Sauvignon grapes

Zhiyu Liu
Chunmei Zhu
Baolong Zhao
ResearchOpen Access24 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Association of visceral and subcutaneous fat with bone mineral density in US adults: a cross-sectional study

Yanze Lin
Xugang Zhong
Fabo Feng
ResearchOpen Access01 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
The nomogram based on the 6-lncRNA model can promote the prognosis prediction of patients with breast invasive carcinoma

Dankun Luo
Wenchao Yao
Biao Ma
ResearchOpen Access21 Oct 2021
Scientific Reports

Volume: 11, P: 1-17
The association of clinical correlates, metabolic parameters, and thyroid hormones with suicide attempts in first-episode and drug-naïve patients with major depressive disorder comorbid with anxiety: a large-scale cross-sectional study

Yongjie Zhou
Wenchao Ren
Xiang Yang Zhang
ResearchOpen Access04 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-7
Disrupted topological organization of structural brain networks in childhood absence epilepsy

Wenchao Qiu
Chuanyong Yu
Xiaoshan Wang
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-10

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