Nature Search

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis

The cell death effector Gasdermin A is only known to be activated by Streptococcus pyogenes. This work discovers a mechanism for its activation by Staphylococcus aureus, and shows a conserved role in immunity against invasive skin pathogens

Doris L. LaRock
Jacob D. Sherman
Christopher N. LaRock
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-9
Neural landscape diffusion resolves conflicts between needs across time

Behavioural and electrophysiological studies in simultaneously thirsty and hungry mice reveal a neural basis for resolving conflicts between needs, in which choices are guided by a persistent and distributed neural goal state that undergoes spontaneous transitions between goals.

Ethan B. Richman
Nicole Ticea
Liqun Luo
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 571-579
A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

A. Gil
N. J. Proudfoot
Research29 Nov 1984
Nature

Volume: 312, P: 473-474
A gasdermin-based life–death evolution system for reprogramming protease specificity

An in vivo selection system based on the toxicity regulation of the N-terminal domain of gasdermin D and evolution of tobacco etch virus protease (TEVp) has been developed. The method enables development of a TEVp capable of precise cleavage of specific sequences on target proteins.

Ziqi Gao
Tianzhen Li
Jie Wang
Research31 Oct 2025
Nature Chemical Biology

Volume: 22, P: 87-96
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

Christopher Abbosh
Nicolai J. Birkbak
Charles Swanton
Research26 Apr 2017
Nature

Volume: 545, P: 446-451
A multimodal cell census and atlas of the mammalian primary motor cortex

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Edward M. Callaway
Hong-Wei Dong
Susan Sunkin
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 86-102
DeKinomics pulse-chases kinase functions in living cells

Weng et al. developed a photocaged lysine-based gain-of-function strategy termed DeKinomics to systematically dissect kinase activity with high specificity and temporal resolution under living conditions.

Yicheng Weng
Wendong Chen
Peng R. Chen
Research02 Jan 2024
Nature Chemical Biology

Volume: 20, P: 615-623
Jellyfish genomes reveal distinct homeobox gene clusters and conservation of small RNA processing

Jellyfish plays an important ecological role in surface waters and the deep sea. Here the authors report genome sequences of two true jellyfish, Sanderia malayensis and Rhopilema esculentum, showing distinct homeobox gene clusters and sesquiterpenoid pathway.

Wenyan Nong
Jianquan Cao
Jerome H. L. Hui
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-11
The coral core microbiome identifies rare bacterial taxa as ubiquitous endosymbionts

Tracy D Ainsworth
Lutz Krause
William Leggat
ResearchOpen Access17 Apr 2015
The ISME Journal

Volume: 9, P: 2261-2274
Breaching the great wall: peptidoglycan and microbial interactions

In this Opinion article the authors propose that peptidoglycan is not only an essential structural component of the bacterial cell wall, but is also involved in diverse biological processes, such as microbial pathogenesis, symbiotic associations and a range of interactions between bacteria and other organisms.

Karen A. Cloud-Hansen
S. Brook Peterson
Jo Handelsman
Reviews07 Aug 2006
Nature Reviews Microbiology

Volume: 4, P: 710-716
Haemophilus Influenzae Type B Impairment of Pial Vessel Autoregulation in Rats

Ivor D Berkowitz
William R Hayden
M Douglas Jones Jr.
Research01 Jan 1993
Pediatric Research

Volume: 33, P: 48-51
Optimizing orthogonality

A new pyrrolysyl-tRNA synthetase/^PyltRNA (PylRS/^PyltRNA) pair that is mutually orthogonal to existing PylRS/^PyltRNA pairs has now been discovered and optimized. This system could enable the site-specific incorporation of a greater number of distinct non-canonical amino acids into a protein.

William S. C. Ngai
Peng R. Chen
News & Views20 Jul 2018
Nature Chemistry

Volume: 10, P: 802-803
Neoantigen-directed immune escape in lung cancer evolution

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Rachel Rosenthal
Elizabeth Larose Cadieux
Andrew Kidd
Research20 Mar 2019
Nature

Volume: 567, P: 479-485
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Analysis of whole-genome doubling (WGD) by using cancer sequencing data combined with simulations of tumor evolution suggests that there is negative selection against homozygous loss of essential genes before WGD but not after.

Saioa López
Emilia L. Lim
Nicholas McGranahan
Research05 Mar 2020
Nature Genetics

Volume: 52, P: 283-293
Comprehensive genomic characterization defines human glioblastoma genes and core pathways

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

Roger McLendon
Allan Friedman
Elizabeth Thomson
Research04 Sept 2008
Nature

Volume: 455, P: 1061-1068
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu et al. utilize multiparametric analysis of early-stage human NSCLC to characterize a population of Vδ1 T cells displaying a resident memory and effector memory phenotype, which were associated with ongoing remission.

Yin Wu
Dhruva Biswas
Charles Swanton
ResearchOpen Access30 May 2022
Nature Cancer

Volume: 3, P: 696-709
Using DNA sequencing data to quantify T cell fraction and therapy response

A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in tumours, and enables prediction of tumour responses to immune checkpoint inhibition therapy.

Robert Bentham
Kevin Litchfield
Nicholas McGranahan
Research08 Sept 2021
Nature

Volume: 597, P: 555-560
Oxygen Free Radicals and the Cerebral Arteriolar Response to Group B Streptococci

Alice A McKnight
William G Keyes
M Douglas Jones Jr.
Research01 Jun 1992
Pediatric Research

Volume: 31, P: 640-644
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1549-1559
Long term efficacy of first-line afatinib and the clinical utility of ctDNA monitoring in patients with suspected or confirmed EGFR mutant non-small cell lung cancer who were unsuitable for chemotherapy

Sanjay Popat
Adam Januszewski
William Wilson
ResearchOpen Access05 Dec 2024
British Journal of Cancer

Volume: 132, P: 245-252
Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1147
The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani et al. use a multiomics approach to characterize the effect of tumour mutational burden on the differentiation of CD4 and CD8 T cell subpopulations in non-small cell lung cancer.

Ehsan Ghorani
James L. Reading
Sergio A. Quezada
Research22 May 2020
Nature Cancer

Volume: 1, P: 546-561
A clonal expression biomarker associates with lung cancer mortality

TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1540-1548
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1534-1539
Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis

Jeffery Ho
Wajia He
Shirley P. C. Ngai
ResearchOpen Access18 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

Khalid AbdulJabbar
Shan E. Ahmed Raza
Yinyin Yuan
Research27 May 2020
Nature Medicine

Volume: 26, P: 1054-1062
Horseshoe crab genomes reveal the evolution of genes and microRNAs after three rounds of whole genome duplication

Wenyan Nong, Zhe Qu, Yiqian Li, Tom Barton-Owen, Annette Wong and colleagues provide genomes and small RNA transcriptomes for the mangrove horseshoe crab and the tri-spine horseshoe crab. They show that horseshoe crabs have undergone three rounds of whole genome duplication and shed light on how gene families and microRNAS evolved following this genome duplication event.

Wenyan Nong
Zhe Qu
Jerome H. L. Hui
ResearchOpen Access19 Jan 2021
Communications Biology

Volume: 4, P: 1-11
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148

Search

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis

Neural landscape diffusion resolves conflicts between needs across time

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

A gasdermin-based life–death evolution system for reprogramming protease specificity

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

A multimodal cell census and atlas of the mammalian primary motor cortex

DeKinomics pulse-chases kinase functions in living cells

Jellyfish genomes reveal distinct homeobox gene clusters and conservation of small RNA processing

The coral core microbiome identifies rare bacterial taxa as ubiquitous endosymbionts

Breaching the great wall: peptidoglycan and microbial interactions

Haemophilus Influenzae Type B Impairment of Pial Vessel Autoregulation in Rats

Optimizing orthogonality

Neoantigen-directed immune escape in lung cancer evolution

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Using DNA sequencing data to quantify T cell fraction and therapy response

Oxygen Free Radicals and the Cerebral Arteriolar Response to Group B Streptococci

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Long term efficacy of first-line afatinib and the clinical utility of ctDNA monitoring in patients with suspected or confirmed EGFR mutant non-small cell lung cancer who were unsuitable for chemotherapy

Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

A clonal expression biomarker associates with lung cancer mortality

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Horseshoe crab genomes reveal the evolution of genes and microRNAs after three rounds of whole genome duplication

Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

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