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Rising electricity and freshwater needs limit conventional hydrogen production. Here, the authors report a self-sufficient, electricity-free system that harvests atmospheric moisture to produce green hydrogen, offering a scalable and sustainable path to alleviate global green-hydrogen scarcity.

Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

Single-cell atlas reveals depot-specific cellular diversity of sheep adipose tissues, identifying BMP5 as a key candidate ligand gene regulating tail fat development.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

Currently, there is limited understanding of the molecular subtypes of fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Here, the authors employ integrated genomics and transcriptomics to develop a CpG site-specific methylation signature for the identification of FH-deficient RCC, and to identify three distinct molecular subtypes for this rare but highly lethal kidney cancer.

This study provides prognostic models for clinical translation and reveals methylation biomarkers and mechanisms of CAD adverse outcomes.

Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

In this study, the authors present that deep brain stimulation of lateral hypothalamic area activates a hypothalamic-pontine-spinal pathway, promoting locomotor initiation and functional recovery after spinal cord injury in mice.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Yang, Li, Huang, Ji, Luo, Jiang and colleagues report that chemotherapy induces MLKL PARylation and necroptosis in tumour endothelial cells, which in turn affects tumour-associated macrophages and CD8⁺ T cells, promoting immunosuppression and tumorigenesis.

TFE3-translocation renal cell carcinoma (TFE3-tRCC) is a rare subtype of kidney cancer with no standard treatment options for the advanced disease. Here, the authors perform genomic and transcriptomic profiling of 63 untreated primary TFE3-tRCC tumours and reveal potential therapeutic targets.

Analysis of interactions between the wheels of the Zhurong rover and the terrain along the rover’s traverse reveals soils with high bearing strength and cohesion.

Echinacoside (ECH) is the representative phenylethanoid glycosides (PhGs) that are responsible for the bioactivities of traditional Chinese medicine Cistanche Herba. Here, the authors elucidate the biosynthetic pathway of ECH in Cistanche tubulosa and synthesize 23 PhGs in tobacco.

Here, the authors report that Pseudomonas aeruginosa virulence in Drosophila is not immediate upon infection, but instead it is acquired through a priming process elicited by N-acetyl-glucosamine (NAG) that involves a morphological switch.

This solar-driven interfacial desalination research integrates 3D printed modules modifications, decoupling design, anticorrosion treatment for high desalination efficiency and long-term stability. This self-floating setup utilizes natural cooling seawater to conduct thermal convection for downward freshwater collection.

Iodide-related defects pose serious challenges to the irradiation, thermal, light or reverse-bias stabilities of perovskite solar cells. Here, the authors find that by using the iodide/polyiodide capture and confine effects of perfluorodecyl iodide interfacing with perovskites, inverted perovskite solar cells achieve much improved stabilities.

In this work, authors demonstrate a self-sufficient fog harvester system that simultaneously produces nitrogen-based nutrients for fertilizer via spark-driven nitrogen fixation. The device has the potential to enhance crop growth sustainably without additional energy input or pollutant emissions.

Alpha-fetoprotein is a known biomarker for hepatocellular carcinoma. Here, the authors analyse differences between AFP positive and negative patients to identify alterations in androgen receptor signalling.

Filamentous phages Pf4 and Pf6 are integrated into Pseudomonas aeruginosa. Here, the authors investigate the crosstalk between these two prophages and reveal its contribution to biofilm formation, maintenance of polylysogeny and pathogenicity.

Here, the authors fabricate hybrid van der Waals heterostructures based on 2D tessellations of DNA origami thin films, graphene and boron nitride, showing that the DNA films can induce periodic superlattices at the interface and modulate the electronic properties of the samples.

Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g. Omicron).

Although theoretical advances in the reactivity of organic compounds have progressed rapidly, a complete understanding of the causal relationships between molecular structures and reaction outcomes based solely on first principles remains elusive. Here, the authors use an in-house HTE platform to conduct over 11,000 distinct acid amine couplings, with an accompanying Bayesian neural network model that gives a prediction accuracy of 89.48% for reaction feasibility.

Sun et al show that low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli, offering insights into host-pathogen interactions that could inform future therapeutic strategies.

Tuberculosis is a major global health issue. Here the authors report Mycobacterium-pre-activated macrophage membrane-coated photothermal nanoparticles for targeted tuberculous granuloma and pathogen dual imaging and antibacterial photothermal therapy.

Here the authors report that a thermophilic archaeal TnpB enables efficient gene editing in the natural host: they see that the TnpB has different TAM requirements for eliciting cell death and for facilitating gene editing. They show that TnpB can be harnessed for flexible single-nucleotide editing with templated repair.

The regulation of oncogenic protein sulfiredoxin-1 (SRX) remains to be understood. Here the authors show that SRX is targeted for ubiquitination and degradation by Keap1, the substrate-specific adaptor of the Cullin3 RING E3 ubiquitin ligase complex. Inactivation of Keap1 leads to accumulation of SRX and progression of colorectal cancer.

Bone-tendon interface repair is a challenge due to the transition between tissues. Here the authors report on magnetic Janus hydrogel microrobots loaded with dual bioactive ions for controlling cell phenotype and structure to promote healing of the bone-tendon interface in rotator cuff tear reconstruction surgery.

Circular ADAR-recruiting RNAs improve RNA editing in vitro and in a mouse disease model.

Subthalamic nucleus (STN) deep brain stimulation (DBS) treats Parkinson’s disease effectively only at high frequencies. Authors show high- (not low-) frequency DBS desynchronizes GABA release and STN neuron firing, suggesting a therapeutic mechanism.

To evaluate the efficacy of CAR-γδ T cells for GBM, this study developed the Micro-GRA&FLU platform. This low-cost, scalable platform provides a physiologically relevant model for assessing personalized immunotherapy for GBM.

This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalamic organization.

The ‘Pf’ bacteriophages of Pseudomonas aeruginosa play roles in biofilm formation and virulence. Here, the authors identify a prophage regulatory module, KKP (kinase-kinase-phosphatase), that controls virion production of co-resident Pf prophages and mediates host defense against diverse lytic phages.

Understanding the factors that hamper immune therapy in breast cancer may increase the range of patients who benefit. Here authors show that breast cancer cells produce and subsequently transfer active TGF-β type II receptors to CD8 + T cells to render them exhausted, thus paralyzing the anti-tumor immune response.

Adipose tissue thermogenesis plays a role in appropriate response to cold exposure through incompletely understood mechanisms. Here the authors report that acute cold exposure increases the serum levels of bradykinin, which induces brown adipose tissue thermogenesis and white adipose tissue browning in male mice.

Competition among species in the coral microbiome has important outcomes in terms of coral health, but little is known about the mechanisms allowing pathogens to gain a competitive advantage. Here the authors show that the pathogen Vibrio coralliilyticus outcompetes commensal bacteria by inducing prophages.

How the random solid solution (RSS) alloys accommodate plasticity and overcome strength-ductility trade-off remain unresolved. Here, the authors reveal atomic-scale plastic deformation of AuCu alloy, which shed light on the effect of chemical inhomogeneity on plastic deformation of RSS alloys.