Nature Search

Pancreatic-targeted lipid nanoparticles based on organ capsule filtration

Elucidation of fundamental pancreatic-targeted mechanisms enables the development of lipid nanoparticles for the precise delivery of nucleic acid therapeutics to the pancreas, highlighting their promising potential in the treatment of pancreatic diseases.

Jiaqi Lei
Kai Yang
Guocan Yu
Research25 Feb 2026
Nature

Volume: 652, P: 220-229
Selenium substitution for dielectric constant improvement and hole-transfer acceleration in non-fullerene organic solar cells

Dielectric constant of non-fullerene acceptors plays a critical role in organic solar cells in terms of exciton dissociation and charge recombination. Here, authors report selenium substitution on central core of acceptors to improve dielectric constant, realizing devices with efficiency of 19.0%.

Xinjun He
Feng Qi
Wallace C. H. Choy
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-9
Peritoneal MSCs-derived exosomes suppress CCL24 synthesis through miR-320d delivery contributing to the improvement of peritoneal dialysis-associated fibrosis

Xinhui Zhao
Minhui Xi
Jingyuan Lu
ResearchOpen Access04 Mar 2026
Scientific Reports

Volume: 16, P: 1-16
Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease

NIID is a neurodegenerative disease caused by GGC repeat expansions within NOTCH2NLC gene. Here, authors develop a precise gene-editing therapy that effectively treats the disease in multiple models.

Nina Xie
Yongcheng Pan
Qiong Liu
ResearchOpen Access13 Jan 2026
Nature Communications

Volume: 17, P: 1-16
Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature

The authors demonstrate that plasma exosomes from children with idiopathic short stature contain elevated hsa-miR-17-3p, that disrupts growth signaling and impairs cartilage cell proliferation. A capsaicin-rich diet in rats triggered gut inflammation, increased exosomal miR-17-3p and recapitulated features of idiopathic short stature.

Yameng Wang
Zhiwen Wu
Jingyu Jia
ResearchOpen Access30 Dec 2025
Nature Communications

Volume: 17, P: 1-22
Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas

Ovarian endometriomas, with distinct microenvironment and heightened hormonal sensitivity, are recognized as precursors of ovarian carcinomas. This study decodes ovarian endometriomas by integrating single-cell and spatial transcriptomics with spatial metabolomics to reveal key markers and altered pathways, offering new avenues for diagnosis and therapy.

Yujuan Qi
Xia Chen
Jun Yu
ResearchOpen Access22 Nov 2025
Nature Communications

Volume: 16, P: 1-17
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation

Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammation downstream of IL-17D signaling.

Xinhui Ni
Yi Xu
Yuping Lai
ResearchOpen Access21 Oct 2022
Nature Immunology

Volume: 23, P: 1577-1587
Polyatomic molecules with emission quantum yields >20% enable efficient organic light-emitting diodes in the NIR(II) window

A new series of self-assembled Pt(II) complexes with high emission quantum yields enables OLEDs with a maximum emission wavelength of 995 nm and an external quantum efficiency of 4.3%.

Sheng-Fu Wang
Bo-Kang Su
Pi-Tai Chou
Research10 Oct 2022
Nature Photonics

Volume: 16, P: 843-850
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion

The mediators of bone-fat axis remain largely unknown. Here, the authors show SHN3 gene-deficiency in bone can protect mouse models from weight gain driven by diet-induced obesity through secreting a bone-derived cytokine, C-fragment of SLIT2, which could stimulate adipocyte browning.

Zan Li
Baohong Shi
Ren Xu
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Convergence and divergence of diploid and tetraploid cotton genomes

High-quality assemblies of 15 diploid and 35 allotetraploid cotton accessions are analyzed in graph-based pan-genomes, providing insights into genome dynamics and regulatory control of fiber transcriptomes under varying ploidy and selection pressures.

Jianying Li
Zhenping Liu
Maojun Wang
Research29 Oct 2024
Nature Genetics

Volume: 56, P: 2562-2573
Spin coating epitaxial heterodimensional tin perovskites for light-emitting diodes

A one-step spin-coating approach to fabricate scalable epitaxial heterodimensional tin perovskite thin films results in near-infrared tin perovskite LEDs with a peak external quantum efficiency of 11.6%.

Hao Min
Nana Wang
Jianpu Wang
Research12 Jan 2024
Nature Nanotechnology

Volume: 19, P: 632-637
Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.

Xiaojing Chi
Xiuying Liu
Wei Yang
ResearchOpen Access10 Sept 2020
Nature Communications

Volume: 11, P: 1-7
Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers

In cancer, long noncoding RNAs (lncRNAs) can regulate immune-related pathways. Here, the authors present ImmLnc, an algorithm that can help prioritise immune-related lncRNAs in cancer immunotherapy research

Yongsheng Li
Tiantongfei Jiang
Xia Li
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-13
miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Peng Zou
Menghai Zhu
Ji Yi
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

The classification of breast lesions as indolent or aggressive to tailor treatment is crucial. Here, the authors use single-cell transcriptomics and multiparametric imaging of a breast cancer mouse model, report distinct tumor-immune features for the two types of lesions, and suggest the role of IL-17 signaling in disease progression.

Vidya C. Sinha
Amanda L. Rinkenbaugh
Helen Piwnica-Worms
ResearchOpen Access18 Aug 2021
Nature Communications

Volume: 12, P: 1-17
Boosting fast energy storage by synergistic engineering of carbon and deficiency

High-rate electrode materials are the key to fast-charging batteries that can store large quantities of charge in minutes or even seconds. Here the authors introduce adaptive carbon layer to oxygen defective Ti₂Nb₁₀O₂₉ forming composite electrodes that deliver impressive rate performance and stability.

Shengjue Deng
He Zhu
Jiangping Tu
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-11
Interpretable deep learning for multicenter gastric cancer T staging from CT images

Guoliang Zheng
Huan Wang
Yan Zhao
ResearchOpen Access20 Dec 2025
npj Digital Medicine

Volume: 9, P: 1-12
Chromosome-level genome assembly of the butterfly hillstream loach Beaufortia pingi

Qi Shen
Xinhui Zhang
Shaokui Yi
ResearchOpen Access20 Nov 2024
Scientific Data

Volume: 11, P: 1-7
RETRACTED ARTICLE: A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats

Dongtao Wang
Jianping Chen
Shunmin Li
ResearchOpen Access23 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Exploring the role and mechanism of Astragalus membranaceus and radix paeoniae rubra in idiopathic pulmonary fibrosis through network pharmacology and experimental validation

Huanyu Jiang
Rui Zhou
Quanyu Du
ResearchOpen Access04 Sept 2023
Scientific Reports

Volume: 13, P: 1-16
Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers

Shucheng Si
Jiqing Li
Fuzhong Xue
Research20 Oct 2021
British Journal of Cancer

Volume: 125, P: 1570-1581
Impact of bone marrow fibrosis on outcomes of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

Haixiao Zhang
Wenwen Guo
Erlie Jiang
ResearchOpen Access27 Aug 2024
Bone Marrow Transplantation

Volume: 59, P: 1654-1666
Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer

Reid T. Powell
Amanda L. Rinkenbaugh
Helen Piwnica-Worms
ResearchOpen Access27 May 2024
npj Breast Cancer

Volume: 10, P: 1-12
Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Qi Yang
Hui Dang
Peng Hou
ResearchOpen Access05 Apr 2023
Oncogene

Volume: 42, P: 1634-1648
The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ⁺CD8αα⁺ intestinal intraepithelial lymphocytes

Haohao Zhang
Yiming Hu
Xiaoren Zhang
ResearchOpen Access09 Jan 2022
Cell Death & Differentiation

Volume: 29, P: 1349-1363
Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

Reid T. Powell
Abena Redwood
Helen Piwnica-Worms
ResearchOpen Access21 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Silicon alleviates salinity stress in licorice (Glycyrrhiza uralensis) by regulating carbon and nitrogen metabolism

Jiajia Cui
Enhe Zhang
Qi Wang
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
Discrimination of geographical origin of cultivated Polygala tenuifolia based on multi-element fingerprinting by inductively coupled plasma mass spectrometry

Yunsheng Zhao
Xiaofang Ma
Hong Sui
ResearchOpen Access03 Oct 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Pancreatic-targeted lipid nanoparticles based on organ capsule filtration

Selenium substitution for dielectric constant improvement and hole-transfer acceleration in non-fullerene organic solar cells

Peritoneal MSCs-derived exosomes suppress CCL24 synthesis through miR-320d delivery contributing to the improvement of peritoneal dialysis-associated fibrosis

Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease

Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature

Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas

IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation

Polyatomic molecules with emission quantum yields >20% enable efficient organic light-emitting diodes in the NIR(II) window

Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion

Convergence and divergence of diploid and tetraploid cotton genomes

Spin coating epitaxial heterodimensional tin perovskites for light-emitting diodes

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

Boosting fast energy storage by synergistic engineering of carbon and deficiency

Interpretable deep learning for multicenter gastric cancer T staging from CT images

Chromosome-level genome assembly of the butterfly hillstream loach Beaufortia pingi

RETRACTED ARTICLE: A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats

Exploring the role and mechanism of Astragalus membranaceus and radix paeoniae rubra in idiopathic pulmonary fibrosis through network pharmacology and experimental validation

Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers

Impact of bone marrow fibrosis on outcomes of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer

Hypoxia switches TET1 from being tumor-suppressive to oncogenic

The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ⁺CD8αα⁺ intestinal intraepithelial lymphocytes

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

Silicon alleviates salinity stress in licorice (Glycyrrhiza uralensis) by regulating carbon and nitrogen metabolism

Discrimination of geographical origin of cultivated Polygala tenuifolia based on multi-element fingerprinting by inductively coupled plasma mass spectrometry

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