Nature Search

NALIRIFOX versus gemcitabine plus nab-paclitaxel in Chinese patients with advanced pancreatic adenocarcinoma: a randomized, open-label phase II trial

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Chuntao Gao
Yanqiao Zhang
Jihui Hao
ResearchOpen Access16 Jan 2026
Nature Communications

P: 1-11
General phase segregation and phase pinning effects in lanthanide-doped lead halide perovskite with dual-wavelength lasing

He et al. report a lanthanide-doping strategy for dual-halogen-alloyed perovskite microplates, which promotes phase segregation and facilitates ion migration in the alloyed case, while suppressing it in the phase-segregated state, resulting in dual-wavelength lasing in visible spectral region.

Junyu He
Jun Luo
Xiujuan Zhuang
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 16, P: 1-9
First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer: a phase 2 trial

In the multicenter phase 2 OptiTROP-Lung01 trial in patients with treatment-naive advanced non-small-cell lung cancers, the antibody–drug conjugate sacituzumab tirumotecan with anti-PD-L1 tagitanlimab was safe and showed encouraging clinical efficacy.

Shaodong Hong
Qiming Wang
Wenfeng Fang
Research19 Aug 2025
Nature Medicine

Volume: 31, P: 3654-3661
Ductal lavage followed by observation versus oral corticosteroids in idiopathic granulomatous mastitis: A randomized trial

Ductal lavage represents a treatment option for idiopathic granulomatous mastitis. Here, the authors report the results of a randomized clinical trial, indicating that ductal lavage followed by observation is non-inferior to oral corticosteroids

Xiaolin Chen
Heng Huang
Kai Chen
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-10
CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Jia Liu
Jianwei Yang
Lin Shen
ResearchOpen Access16 Jul 2025
Nature Medicine

Volume: 31, P: 3028-3036
Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study

Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Here the authors report the results of a phase 1b trial of the liposomal irinotecan HE072 in patients with metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy.

Ying Fan
Qingyuan Zhang
Binghe Xu
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Expression level is a major modifier of the fitness landscape of a protein coding gene

Measuring fitness effects of mutations in the same gene expressed at two levels, the authors show expression dependency of fitness effects in at least 42% of all single-nucleotide mutations, probably driven by avoidance of stochastic molecular errors.

Zhuoxing Wu
Xiujuan Cai
Xiaoshu Chen
Research18 Nov 2021
Nature Ecology & Evolution

Volume: 6, P: 103-115
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

Lulu Sun
Cen Xie
Changtao Jiang
Research05 Nov 2018
Nature Medicine

Volume: 24, P: 1919-1929
First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Lin Shen
Yanqiao Zhang
Jiafu Ji
Research22 Jan 2025
Nature Medicine

Volume: 31, P: 1163-1170
Anisotropic charge trapping in phototransistors unlocks ultrasensitive polarimetry for bionic navigation

The direct linear dichroism photodetection without external optics is crucial for applications. Here, Jie et al. exploit the anisotropic charge trapping in organic phototransistors to achieve the dichroic ratio of 10⁴ and to demonstrate a polarizer-free celestial compass for bio-inspired navigation.

Jing Pan
Yiming Wu
Jiansheng Jie
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-11
Isolation and Characterization of Key Genes that Promote Flavonoid Accumulation in Purple-leaf Tea (Camellia sinensis L.)

Xiujuan He
Xuecheng Zhao
Yunsheng Wang
ResearchOpen Access09 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Globally reduced N⁶-methyladenosine (m⁶A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

Global reduction of m⁶A leads to mRNA stabilization in ALS/FTD caused by C9ORF72 repeat expansion. m⁶A also regulates repeat RNA decay. Elevating m⁶A reduces RNA and dipeptide repeats, restores mRNA homeostasis and improves patient neuron survival.

Yini Li
Xiaoyang Dou
Shuying Sun
Research26 Jun 2023
Nature Neuroscience

Volume: 26, P: 1328-1338
Arbuscular mycorrhizal trees influence the latitudinal beta-diversity gradient of tree communities in forests worldwide

The relationship of mycorrhizal associations with latitudinal gradients in tree beta-diversity is unexplored. Using a global dataset approach, this study examines how trees with arbuscular mycorrhizal and ectomycorrhizal associations contribute to latitudinal beta-diversity patterns and the environmental controls of these patterns.

Yonglin Zhong
Chengjin Chu
Jess K. Zimmerman
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-12
Identification of novel NDUFA3 variants in a patient with mitochondrial disorders

Yu Sun
Xiujuan Wei
Yongguo Yu
Research02 Oct 2025
Pediatric Research

P: 1-10
Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor

Yuyan Liu
Rongjie Wei
Yanhua Chu
ResearchOpen Access18 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
The ⁴⁰Ar/³⁹Ar dating of quartz: new insights into the metallogenic chronology of the Jinchang gold deposit and its geological significance

Kaituo Shi
Keyong Wang
Rui Wang
ResearchOpen Access17 Sept 2018
Scientific Reports

Volume: 8, P: 1-8
Author Correction: First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial

Lin Shen
Yanqiao Zhang
Jiafu Ji
Amendments and Corrections26 Mar 2025
Nature Medicine

Volume: 31, P: 1368
Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells

Lei Qi
Xiujuan Lv
Liming Dai
ResearchOpen Access01 Jun 2016
Scientific Reports

Volume: 6, P: 1-8
A bio-inspired coordination polymer as outstanding water oxidation catalyst via second coordination sphere engineering

Proton-coupled electron transfer (PCET) process is very important for water oxidation catalysis. Here, the authors introduced uncoordinated carboxylate in the second-coordination-sphere of Ni-Fe coordination polymer catalyst as an internal base to promote the water oxidation kinetics by such PCET process.

Wenlong Li
Fusheng Li
Licheng Sun
ResearchOpen Access07 Nov 2019
Nature Communications

Volume: 10, P: 1-11
Quantification of the impact of aerosol on broadband solar radiation in North China

Bo Hu
Xiujuan Zhao
Jinyuan Xin
ResearchOpen Access21 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
A Class of High Performance Metal-Free Oxygen Reduction Electrocatalysts based on Cheap Carbon Blacks

Xiujuan Sun
Ping Song
Wei Xing
ResearchOpen Access26 Aug 2013
Scientific Reports

Volume: 3, P: 1-5
VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

Vascular endothelial growth factor is implicated in blood vessel development. In zebrafish, Hayashi et al. find that blood vessel development is dependent on the suppression of vascular endothelial growth factor by the phosphatase VE-PTP, which is recruited by activation of the angiopoietin receptor Tie2.

Makoto Hayashi
Arindam Majumdar
Lena Claesson-Welsh
ResearchOpen Access09 Apr 2013
Nature Communications

Volume: 4, P: 1-15
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial

Dan-Yun Ruan
Wen-Wen Huang
Hongyun Zhao
ResearchOpen Access28 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-12
Macular buckling alone versus combined inverted ILM flap on macular hole-associated macular detachment in patients with high myopia

Xiujuan Zhao
Huiying Song
Lin Lu
ResearchOpen Access31 Jan 2023
Eye

Volume: 37, P: 2730-2735
Cultivating global minds: the development of undergraduates’ international capabilities at an elite university in China’s Yangtze River Delta

Lingqin Zeng
Xiujuan Sun
Chen Ding
ResearchOpen Access21 Aug 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-10
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population.

Yongyong Shi
Han Zhao
Zi-Jiang Chen
Research12 Aug 2012
Nature Genetics

Volume: 44, P: 1020-1025
iTRAQ-based quantitative proteomic analysis reveals alterations in the metabolism of Actinidia arguta

Miaomiao Lin
Jinbao Fang
Yunpeng Zhong
ResearchOpen Access18 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Coupling process of carbon sink service flow based on metacoupling framework

Yan Zhang
Dongjie Guan
Kangwen Zhu
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-23
One country with two systems: The characteristics and development of higher education in the Guangdong–Hong Kong–Macau Greater Bay Area

Xiujuan Xie
Xu Liu
Ian McNay
ResearchOpen Access03 Jan 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-11
Safety and efficacy of 0.02% and 0.01% atropine on controlling myopia progression: a 2-year clinical trial

Can Cui
Xiujuan Li
Aicun Fu
ResearchOpen Access15 Nov 2021
Scientific Reports

Volume: 11, P: 1-8
Single and joint exposure of Pb, Cd, Hg, Se, Cu, and Zn were associated with cognitive function of older adults

Zixuan Fu
Xiaofang Xu
Xiujuan Yang
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
One-step genome editing of elite crop germplasm during haploid induction

Genome editing is induced in seeds during haploid induction, thereby enabling genome editing in monocot and dicot crops.

Timothy Kelliher
Dakota Starr
Qiudeng Que
Research04 Mar 2019
Nature Biotechnology

Volume: 37, P: 287-292
MFCA-Net: a deep learning method for semantic segmentation of remote sensing images

Xiujuan Li
Junhuai Li
ResearchOpen Access08 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Comprehensive application of bio-char and nitrogen fertilizer in dry-land maize cultivation

Chen Sun
Jiying Sun
Nan Ji
ResearchOpen Access05 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
Baicalin regulates autophagy to interfere with small intestinal acute graft-versus-host disease

Xiaoqi Sun
Michael Pisano
Xing Cui
ResearchOpen Access21 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Regional aerosol forecasts based on deep learning and numerical weather prediction

Yulu Qiu
Jin Feng
Jia Zhu
ResearchOpen Access21 Jun 2023
npj Climate and Atmospheric Science

Volume: 6, P: 1-12
RBC distribution width predicts thrombosis risk in polycythemia vera

Dan Liu
Bing Li
Zhijian Xiao
Research08 Sept 2021
Leukemia

Volume: 36, P: 566-568
Macrophage-derived CD36 + exosome subpopulations as novel biomarkers of Candida albicans infection

Shuo Li
Yanyan Xv
Xiujuan Zhang
ResearchOpen Access26 Jun 2024
Scientific Reports

Volume: 14, P: 1-14
Suppression on plant-parasitic nematodes using a soil fumigation strategy based on ammonium bicarbonate and its effects on the nematode community

Lanxi Su
Yunze Ruan
Qirong Shen
ResearchOpen Access01 Dec 2015
Scientific Reports

Volume: 5, P: 1-13
Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus

Chunmei Yang
Chuanyin Sun
Hongyan Tong
CorrespondenceOpen Access08 May 2025
Cell Research

Volume: 35, P: 607-609
A deep learning system for myopia onset prediction and intervention effectiveness evaluation in children

Ziyi Qi
Tingyao Li
Xun Xu
ResearchOpen Access07 Aug 2024
npj Digital Medicine

Volume: 7, P: 1-10
Correction: Corrigendum: Donkey genome and insight into the imprinting of fast karyotype evolution

Jinlong Huang
Yiping Zhao
Manglai Dugarjaviin
Amendments and CorrectionsOpen Access18 Dec 2015
Scientific Reports

Volume: 5, P: 1
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma

Mingyue Tao
Jing Luo
Qilong Wang
ResearchOpen Access13 Sept 2021
Cell Death & Disease

Volume: 12, P: 1-14
The AaCBF4-AaBAM3.1 module enhances freezing tolerance of kiwifruit (Actinidia arguta)

Shihang Sun
Chungen Hu
Jinbao Fang
ResearchOpen Access01 May 2021
Horticulture Research

Volume: 8, P: 1-15
Mce1C and Mce1D facilitate N. farcinica invasion of host cells and suppress immune responses by inhibiting innate signaling pathways

Xingzhao Ji
Xiujuan Zhang
Zhenjun Li
ResearchOpen Access10 Sept 2020
Scientific Reports

Volume: 10, P: 1-13
Donkey genome and insight into the imprinting of fast karyotype evolution

Jinlong Huang
Yiping Zhao
Manglai Dugarjaviin
ResearchOpen Access16 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera

Dan Liu
Zefeng Xu
Zhijian Xiao
CorrespondenceOpen Access17 Sept 2021
Blood Cancer Journal

Volume: 11, P: 1-4

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