Nature Search

Pathways from early-life urbanicity to adult neurobehavioral traits via menarche timing

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Lining Guo
Feng Liu
Yue Wu
Research15 Dec 2025
Nature Cities

Volume: 2, P: 1226-1239
The genetic architecture of brainstem structures

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Hui Xue
Jilian Fu
Yue Wu
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-18
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

Fusheng Zhou
Hongzhi Cao
Xuejun Zhang
Research23 May 2016
Nature Genetics

Volume: 48, P: 740-746
Decline in Chinese lake phosphorus concentration accompanied by shift in sources since 2006

Many lakes in China are subject to eutrophication. Water quality analyses on 862 Chinese lakes reveal that better sanitation has reduced phosphorus inputs in the most populated areas, but aquaculture and livestock offset improvements elsewhere.

Yindong Tong
Wei Zhang
Yan Lin
Research12 Jun 2017
Nature Geoscience

Volume: 10, P: 507-511
A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid

Here, using a mouse model, the authors show that a lysine-restricted diet counteracts obesity via the enrichment of Parabacteroides goldsteinii and its metabolite MIAA, which in turn leads to suppressed fat accumulation by modulating the FTO-YTHDC1-SLC2A4 pathway.

Feng Zhao
Zhen Zou
Chengzhi Chen
ResearchOpen Access12 Nov 2025
Nature Communications

Volume: 16, P: 1-18
TGM2-P2RX7 loop promotes gemcitabine resistance in pancreatic cancer by modulating glutamine metabolism and mitophagy

Ke Ye
Shuhua Zhou
Shuai Liang
ResearchOpen Access30 Dec 2025
Cell Death Discovery

Volume: 12, P: 1-19
A multimodal machine learning model for the stratification of breast cancer risk

A multimodal model for the stratification of breast cancer risk based on clinical metadata, mammography and trimodal ultrasound images performed as well as or better than radiologists at tumour classification and at differential diagnosis.

Xuejun Qian
Jing Pei
Dinggang Shen
Research04 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 356-370
A large-scale screen for coding variants predisposing to psoriasis

Xuejun Zhang, Jun Wang and colleagues report the application of exome sequencing to a large collection of psoriasis cases and controls. They identify seven common and low-frequency nonsynonymous variants within known psoriasis susceptibility genes that are associated with psoriasis risk.

Huayang Tang
Xin Jin
Xuejun Zhang
Research10 Nov 2013
Nature Genetics

Volume: 46, P: 45-50
Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Qiang Xu
Su Lui
Yue Wu
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 676-687
Correction: Author Correction: Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Xianbo Zuo
Liangdan Sun
Xuejun Zhang
Amendments and CorrectionsOpen Access13 Mar 2018
Nature Communications

Volume: 9, P: 1
Erratum: Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Min Deng
Ling Wei
Xuejun Zhang
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 714
How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Jie Tang
Jing Zhang
Yue Wu
Research31 Mar 2025
Nature Human Behaviour

Volume: 9, P: 1005-1022
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients

Analyses of pretransplant omics data from different cohorts of African American recipients found that genetic polymorphisms at the LILRB3 gene are associated with kidney graft loss.

Zeguo Sun
Zhengzi Yi
Weijia Zhang
Research10 Mar 2025
Nature Medicine

Volume: 31, P: 1677-1687
A domain knowledge-based interpretable deep learning system for improving clinical breast ultrasound diagnosis

Yan, Liang, Zhang et al. propose a domain knowledge-based interpretable deep learning system to improve breast cancer risk prediction from multimodal ultrasound images. Its inherent interpretability enables effective human-machine collaboration and thus may aid clinical decision-making.

Lin Yan
Zhiying Liang
Xuejun Qian
ResearchOpen Access17 May 2024
Communications Medicine

Volume: 4, P: 1-11
Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial

In a prespecified interim analysis of the multicenter, randomized, phase 3 FLAMES trial, maintenance therapy with a PARP inhibitor in patients with ovarian cancer showed prolonged progression-free survival compared with placebo in all subgroups defined by BRCA or homologous recombination status.

Xiaohua Wu
Jihong Liu
Linjuan Zeng
Research15 May 2024
Nature Medicine

Volume: 30, P: 1612-1621
Cross-ancestry genome-wide association studies of brain imaging phenotypes

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Jilian Fu
Quan Zhang
Yue Wu
Research29 May 2024
Nature Genetics

Volume: 56, P: 1110-1120
Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients

Zeguo Sun
Zhengzi Yi
Weijia Zhang
Amendments and Corrections15 Apr 2025
Nature Medicine

Volume: 31, P: 1712
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

Min Deng
Ling Wei
Xuejun Zhang
Research28 Apr 2013
Nature Genetics

Volume: 45, P: 697-700
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that inducing ferroptosis and suppressing TNF signaling reduce fibroblast numbers and ameliorate experimental arthritis.

Jiao Wu
Zhuan Feng
Ping Zhu
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry

Bin Liu
Xuedong Zhou
Jingping Liang
ReviewsOpen Access18 Sept 2023
International Journal of Oral Science

Volume: 15, P: 1-6
A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening

Polygenic Risk Scores (PRS) show promise for facilitating cancer risk stratification. Here, the authors performed a large genome-wide association study and develop a PRS for nasopharyngeal carcinoma, which could improve risk stratification and personalized screening.

Yong-Qiao He
Tong-Min Wang
Wei-Hua Jia
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-10
On the identification of internal solitary waves from moored observations in the northern South China Sea

Qinglong Gong
Liang Chen
Xianqing Lv
ResearchOpen Access23 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
Selective lignin arylation for biomass fractionation and benign bisphenols

By controlling C–C bond formation in catalytic arylation, lignin can be efficiently extracted from biomass and converted into benign bisphenols that can be used as replacements for their fossil-based counterparts.

Ning Li
Kexin Yan
Feng Wang
Research29 May 2024
Nature

Volume: 630, P: 381-386
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al.perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability.

Xianbo Zuo
Liangdan Sun
Xuejun Zhang
ResearchOpen Access09 Apr 2015
Nature Communications

Volume: 6, P: 1-7
Sequencing-based approach identified three new susceptibility loci for psoriasis

Although psoriasis is a chronic disorder affecting approximately 2% of the population, little is known about the underlying genetic architecture. Here, the authors carry out exome sequencing in a large Han Chinese cohort of psoriasis patients and healthy controls, and identify three new genes that may increase risk of developing the disease.

Yujun Sheng
Xin Jin
Xuejun Zhang
Research09 Jul 2014
Nature Communications

Volume: 5, P: 1-6
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Nana Liu
Longjiang Zhang
Yue Wu
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1126-1137
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming

The mitochondrial unfolded protein response is shown to inhibit pluripotency during somatic cell reprogramming and to inhibit the mesenchymal-to-epithelial transition through c-Jun-mediated histone acetylation.

Zhongfu Ying
Yanmin Xin
Xingguo Liu
Research09 Apr 2025
Nature Metabolism

Volume: 7, P: 940-951
Trans-provincial health impacts of atmospheric mercury emissions in China

Mercury (Hg) is a global neurotoxic pollutant and has a long chain from economic activities to human health risks. Here the authors presented a map of Hg-related health risks in China and found significant impacts of interprovincial trade on health risks, such as the prevention of deaths from fatal heart attacks by the trade induced by final consumption.

Long Chen
Sai Liang
Zhifeng Yang
ResearchOpen Access02 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity

Non-syndromic cleft lip with palate is a common birth defect of unknown aetiology. Here, the authors discover 14 new genes associated with this condition, and show genetic heterogeneity in this and other non-syndromic orofacial clefting disorders.

Yanqin Yu
Xianbo Zuo
Zhuan Bian
ResearchOpen Access24 Feb 2017
Nature Communications

Volume: 8, P: 1-11
START smuggling CoQ to fight ferroptosis

Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ.

Deguang Liang
Xuejun Jiang
News & Views19 Jan 2023
Nature Cell Biology

Volume: 25, P: 207-208
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

Leming Shi
Gregory Campbell
Russell D Wolfinger
Research30 Jul 2010
Nature Biotechnology

Volume: 28, P: 827-838
Comparative physiochemical and transcriptomic analysis reveals the influences of cross-pollination on ovary and fruit development in pummelo (Citrus maxima)

Shaohua Wang
Chunrui Long
Xuejun Bei
ResearchOpen Access04 Nov 2023
Scientific Reports

Volume: 13, P: 1-12
Construction of a diagnostic model utilizing m7G regulatory factors for the characterization of diabetic nephropathy and the immune microenvironment

Jingying Zhong
Pengli Xu
Ya Xiao
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-19
Evaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization

Ji Yan
Shu Zhang
Fang Peng
ResearchOpen Access09 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Numerical simulation of size effect of defective rock under compression condition

Zeyu Hu
Liangfu Xie
Jiangu Qian
ResearchOpen Access09 Jan 2023
Scientific Reports

Volume: 13, P: 1-16
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma

Xuya Wang
Xisen Wang
Xuejun Yang
ResearchOpen Access25 Nov 2022
Cancer Gene Therapy

Volume: 30, P: 345-357
Distribution and risk assessment of microplastics in a source water reservoir, Central China

Minghui Shen
Yang Li
Xuejun Duan
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
Mass screening for liver cancer: results from a demonstration screening project in Zhongshan City, China

Mingfang Ji
Zhiwei Liu
Weimin Ye
ResearchOpen Access24 Aug 2018
Scientific Reports

Volume: 8, P: 1-10
EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating α1-AT

Yilixiati Xiaokaiti
Haoming Wu
Xuejun Li
ResearchOpen Access16 Jul 2015
Scientific Reports

Volume: 5, P: 1-14
Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3

Liang Liu
Peng Zhang
Jun Dong
ResearchOpen Access25 May 2021
Cell Death & Disease

Volume: 12, P: 1-12
Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate

Rui Gao
Xingqun Liang
Gergana Dobreva
ResearchOpen Access25 Apr 2019
Cell Research

Volume: 29, P: 486-501
Observation of near-inertial waves in the wake of four typhoons in the northern South China Sea

Qinglong Gong
Qixiang Wang
Xianqing Lv
ResearchOpen Access23 Feb 2023
Scientific Reports

Volume: 13, P: 1-15
KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1

Mingxuan Li
Qian Fang
Rui Zhou
ResearchOpen Access26 Aug 2024
Cell Death & Disease

Volume: 15, P: 1-15
Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis

Bolin Hou
Haiwen Huang
Erwei Li
ResearchOpen Access13 Jul 2022
Cell Death Discovery

Volume: 8, P: 1-10
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

Guo-Qing Chen
Fahad A. Benthani
Xuejun Jiang
Research21 May 2019
Cell Death & Differentiation

Volume: 27, P: 242-254
A new checkpoint against ferroptosis

Deguang Liang
Liang Deng
Xuejun Jiang
Research Highlights26 Nov 2019
Cell Research

Volume: 30, P: 3-4

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