Nature Search

Cholangiocarcinoma derived exosomes attenuate the anti-tumor functions of NK cells

Xinyue Wang
Fan Zhang
Xuelian Bai
ResearchOpen Access20 Jan 2026
Scientific Reports

P: 1-15
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells

Using activity-based chemical probes, oncogenic IDH1-R132H but not the wild type was found to acquire a unique autopalmitoylation at C269. This mutant-specific modification is critical for the enzyme’s abnormal activity in cancer.

Lu Hu
Jinyu Lin
Xu Wu
Research13 Jan 2026
Nature Chemical Biology

P: 1-12
Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

In this study, the authors isolated and characterized neutralizing antibodies from vaccinated individuals with SARS-CoV-2 BA.1 breakthrough infection and show that elite antibodies derived from specific germlines provide potent pan-variant neutralization capacity and in vivo protection.

Yu Guo
Guangshun Zhang
Zihe Rao
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-16
A novel USP27X missense variant identified in an individual with intellectual disability

Sukun Luo
Meng Zhang
Xuelian He
Research02 Jul 2025
Journal of Human Genetics

Volume: 70, P: 489-494
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4⁺CD25⁺ regulatory T cells

Xuelian Hu
Guangwei Liu
Yong Zhao
Research22 Oct 2012
Cellular & Molecular Immunology

Volume: 9, P: 464-472
Sliding-attention transformer neural architecture for predicting T cell receptor–antigen–human leucocyte antigen binding

Predicting TCR–antigen–human leucocyte antigen binding opens the door to neoantigen identification. In this study, a physics-inspired sliding transformer (PISTE) system is used to guide the positioning of amino acid residues along the gradient field of their interactions, boosting binding prediction accuracy.

Ziyan Feng
Jingyang Chen
Honglin Li
ResearchOpen Access27 Sept 2024
Nature Machine Intelligence

Volume: 6, P: 1216-1230
Erratum: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Shuai Wang
Sen Wang
Xuepeng Cai
Amendments and CorrectionsOpen Access03 Nov 2016
Nature Communications

Volume: 7, P: 1-2
The auxin–PLETHORA 5 module regulates wood fibre development in Populus tomentosa

The study reveals that PLETHORA 5, a transcription factor activated by auxin signalling in the vascular cambium, regulates cell expansion and cell wall thickening of fibres by directly repressing SND1 genes during wood formation in Populus tomentosa.

Shuai Liu
Xiaokang Fu
Changzheng Xu
Research19 Mar 2025
Nature Plants

Volume: 11, P: 580-594
Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction

Dusp6, an ERK specific phosphatase, was identified as a regenerative repressor during zebrafish heart regeneration. Here, the authors show that Dusp6 deficiency improves post infarctional cardiac repair by predominantly attenuating neutrophil-mediated myocardial damage in mammalian hearts.

Xiaohai Zhou
Chenyang Zhang
Jing-Wei Xiong
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

Xiangyang Chi
Yingying Guo
Wei Chen
ResearchOpen Access27 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-11
Identification of a super enhancer associated gene signature for the prognosis prediction and regulatory mechanism exploration in breast cancer

Mingcui Li
Zhengbo Fang
Fei Ma
ResearchOpen Access08 Dec 2025
Scientific Reports

Volume: 15, P: 1-17
Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism

Here the authors report the crystal structures of RNase J from Mycobacterium tuberculosis in apo-state and complex with single strand RNA, revealing its physiological function in RNA metabolism.

Luyao Bao
Juan Hu
Jixi Li
ResearchOpen Access20 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Structural basis of tubulin detyrosination by vasohibins

Crystal structures of human VASH1–SVBP alone, in complex with a tyrosine-derived covalent inhibitor and bound to parthenolide, explain the requirement for SVBP during tubulin detyrosination and reveal the basis for substrate recognition.

Faxiang Li
Yingjie Hu
Hongtao Yu
Research24 Jun 2019
Nature Structural & Molecular Biology

Volume: 26, P: 583-591
TSC1 controls macrophage polarization to prevent inflammatory disease

Macrophages can be polarized to inflammatory M1 and anti-inflammatory M2 phenotypes, depending on the cytokine milieu. Here, Zhu et al.demonstrate that tuberous sclerosis complex 1 (TSC1) inhibits M1 and promotes M2 polarization of macrophages to prevent inflammatory disorders.

Linnan Zhu
Tao Yang
Yong Zhao
Research01 Sept 2014
Nature Communications

Volume: 5, P: 1-13
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses

Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes.

Fei Xiao
Denian Wang
Wei Zhang
ResearchOpen Access06 Jul 2018
Nature Communications

Volume: 9, P: 1-15
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma

Yapeng Ji
Junyao Jiang
Hongtao Yu
Research03 Sept 2025
Cell Research

Volume: 35, P: 859-875
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Only one of the three Taenia species causing taeniasis in humans was previously sequenced. Here the authors provide draft genomes of Taenia saginata and Taenia asiatica, analyse genome evolution of all three species, and identify potential targets for developing diagnostic markers or intervention tools.

Shuai Wang
Sen Wang
Xuepeng Cai
ResearchOpen Access22 Sept 2016
Nature Communications

Volume: 7, P: 1-12
Whole-genome sequencing reveals untapped genetic potential in Africa’s indigenous cereal crop sorghum

Sorghum is a drought-resistant food and feed cereal crop used by over half a billion of the world’s poorest people. Here the authors present high-coverage resequencing genome data of 44 sorghum lines of varying geographic and taxonomic origin, which include a number of sorghum wild relatives.

Emma S. Mace
Shuaishuai Tai
Jun Wang
ResearchOpen Access27 Aug 2013
Nature Communications

Volume: 4, P: 1-9
Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.

Minqing Jiang
Lei Liu
Q. Richard Lu
ResearchOpen Access15 Jul 2016
Nature Communications

Volume: 7, P: 1-15
The G protein α subunit Gα_s is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

Deficiency in Gnas, encoding the Gs protein α subunit, is sufficient to induce medulloblastoma in mice due to derepression of the Sonic hedgehog pathway.

Xuelian He
Liguo Zhang
Q Richard Lu
Research24 Aug 2014
Nature Medicine

Volume: 20, P: 1035-1042
Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis

Runze Wang
Shuai Xu
Rui-Ping Xiao
ResearchOpen Access13 Aug 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-13
Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty

Minwen Jie
Tong Feng
Hao Jiang
ResearchOpen Access10 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Mathematical modelling and sliding characteristics analysis on the spherical movable teeth for the toroidal drive

Xuelian Zeng
Ligang Yao
Meiyan Lou
ResearchOpen Access01 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Glofitamab combined with tislelizumab in relapsed/refractory diffuse large B-cell lymphoma: a single-center pilot trial

De Zhou
Wenjuan Yu
Hongyan Tong
CorrespondenceOpen Access01 Nov 2025
Blood Cancer Journal

Volume: 15, P: 1-4
Chinese physicians’ perceptions and willingness to use telemedicine during the COVID-19 pandemic

Xuelian Hai
Jia Zhang
Jay Pan
ResearchOpen Access27 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-10
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50

Yue Sun
Xuelian Ning
Chunshui Zhou
ResearchOpen Access27 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-10
IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation

NF-κB inhibitor alpha (IKBA) signaling in mature sperm drives sperm motility and controls fatty acid b-oxidation metabolism.

Yanquan Li
Youwei Hu
Yuchuan Zhou
ResearchOpen Access25 Mar 2023
Communications Biology

Volume: 6, P: 1-12
Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model

Guangdan Yu
Yixun Su
Jianqin Niu
ResearchOpen Access21 Sept 2022
Molecular Psychiatry

Volume: 27, P: 5154-5166
Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders

Ting Lu
Meiyi Li
Fu Xiong
ResearchOpen Access03 Sept 2018
International Journal of Oral Science

Volume: 10, P: 1-9
Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade

Ruixue Wang
Xuelian Zheng
Xia Wang
ResearchOpen Access31 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Notoginsenoside R1 Alleviates Oxygen–Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC

Yan Wang
Liu Tu
Shali Wang
ResearchOpen Access24 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Heritable gene-targeting with gRNA/Cas9 in rats

Xinli Hu
Nannan Chang
Jing-Wei Xiong
Correspondence22 Oct 2013
Cell Research

Volume: 23, P: 1322-1325
Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

Liang Huang
Dan Liu
Qian-fei Wang
Research17 Nov 2017
Cell Research

Volume: 28, P: 172-186

Search

Cholangiocarcinoma derived exosomes attenuate the anti-tumor functions of NK cells

Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

A novel USP27X missense variant identified in an individual with intellectual disability

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4⁺CD25⁺ regulatory T cells

Sliding-attention transformer neural architecture for predicting T cell receptor–antigen–human leucocyte antigen binding

Erratum: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

The auxin–PLETHORA 5 module regulates wood fibre development in Populus tomentosa

Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction

Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

Identification of a super enhancer associated gene signature for the prognosis prediction and regulatory mechanism exploration in breast cancer

Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism

Structural basis of tubulin detyrosination by vasohibins

TSC1 controls macrophage polarization to prevent inflammatory disease

Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses

Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma

Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Whole-genome sequencing reveals untapped genetic potential in Africa’s indigenous cereal crop sorghum

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

The G protein α subunit Gα_s is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis

Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty

Mathematical modelling and sliding characteristics analysis on the spherical movable teeth for the toroidal drive

Glofitamab combined with tislelizumab in relapsed/refractory diffuse large B-cell lymphoma: a single-center pilot trial

Chinese physicians’ perceptions and willingness to use telemedicine during the COVID-19 pandemic

Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50

IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation

Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model

Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders

Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade

Notoginsenoside R1 Alleviates Oxygen–Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC

Heritable gene-targeting with gRNA/Cas9 in rats

Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

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