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Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Electrochemical urea oxidation enables sustainable hydrogen production but suffers from some catalyst instability. Here the authors create ligand vacancies to induce metal dimerization, stabilizing the framework while achieving stable industrial-scale operation with low energy consumption.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Controlling plant metabolism to improve growth and disease resistance has huge potential. Here, the authors find a conserved pathway which promotes antiviral resistance and promotes plant growth and develop polyglutamate-loaded chitosan nanogels to manipulate this pathway.

How chromatin architecture enforces productive class switching is not fully understood. Here, the authors demonstrate that transcriptional orientation, genomic distance, and Igh domain organization bias AID‑initiated breaks toward deletional joining required for productive CSR.

Capacitive sensors based on electronic polarization typically exhibit low sensitivity as their dielectric modulation is confined to a single mode. Here, the authors develop a dielectric-gradient all-fiber non-ionic electronic skin that converts interfacial impedance into signal amplification for tactile sensing.

Telomere length varies across chromosome arms, but most studies measure only averages. Here, the authors use long‑read sequencing in >2,500 participants to map chromosome‑specific lengths, showing arm‑level variation, strong individual differences, and associations with aging and disease.

Han et al. report a highly conductive composite electrode with low equivalent sheet resistance of 1.5 Ω sq-1. A self-masking method is developed to prevent shunting caused by uneven grid surfaces, enabling flexible organic solar cells with efficiencies of 15.20% (4 cm² devices) and 14.24% (16 cm² devices).

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

Wearable energy-harvesting devices suffer from low electrical output and poor wear comfort. Here, authors develop a self-powered fabric with good wear comfort that pumps sweat directionally, achieving 6.3 °C skin cooling and a 0.40 mA·cm⁻² DC current output for practical wearable power supply.

Here, the authors establish 1,3-propanediol, a low-cost biomass-derived bulk chemical, as an efficient, green, and sustainable C1 source for the mono-N-methylation of primary amines, via chelation-free C(sp3)−C(sp3) bond cleavage.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

Improving crop yield very often comes at the cost of crop quality and stress resistance. Here, the authors report that gene editing of the thiamine pyrophosphate riboswitch in rice leads to elevated levels of various vitamins and phytonutrients, as well as resistance to cold and blast disease without penalty on grain yield.

Tuning the emission of metal nanoclusters is a challenge. Here, the authors report on solvation-induced isomerization and modulation of electron transfer dynamics to achieve controllable emission across the entire visible range.

Here, the authors present a machine-learning assisted single-molecule sensor that can precisely quantify the structurally diverse per- and polyfluoroalkyl carboxylic acids in the absence of standards, together with state-of-the-art detection limits.

Aqueous zinc batteries suffer from poor reversibility due to interfacial instability. Here, the authors propose an electric field-responsive electrolyte design that modulates zinc-ion solvation and interfacial chemistry, leading to uniform deposition and extended cycling stability.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

The authors propose here a computing-in-memory architecture based on tunable Gaussian like memory cells for processing Kolmogorov-Arnold networks, to achieve parallel computation with higher energy efficiency compared to general-purpose CMOS architectures.

Deep brain stimulation is effective but invasive. Here, the authors develop an injectable conductive hydrogel that forms in situ and enables wireless neuromodulation under volume conduction via capacitive coupling, showing therapeutic potential in a Parkinson’s disease rat model

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

By forming an electron reservoir in the centre of a gallium nitride nanowire p–n diode, a single two-terminal device can be created that offers sensing, memory and synaptic functionalities, and arrays of such devices can be used to denoise and identify optical images.

ReactionSeek leverages large language models to automate data mining from organic chemistry literature. It extracts complex reaction parameters with high precision, creating AI-ready datasets to accelerate chemical discovery.

Scaling is a major challenge in engineered systems. This study employs in situ synchrotron X-ray scattering to reveal how organic matter alters nucleation and crystallization pathways, thereby regulating gypsum scaling on desalination membranes.

Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

A dual-action force dynamics strategy using a hard silicon template as a nanoimprinting stamp combined with inverted transfer printing is described for the manufacture of high-performance full-colour ultrahigh-resolution quantum dot light-emitting diodes (LEDs) for active-matrix displays, while revealing electric-field reconstruction in nanoscale arrays and introducing dielectric matching to mitigate field concentration and performance degradation.

MiRNAs and natural antisense transcripts can both regulate gene expression and plant development. Here, the authors show that cis-NATs to MIR398 repress processing of pri-miR398 and that cis-NAT expression is downregulated at high temperatures, contributing to miR398 mediated thermotolerance responses.

Photochargeable semiconductors offer a promising route to overcoming efficiency limits in photocatalytic transformations. Now it has been shown that zinc indium sulfide nanocrystals with a high charge storage capacity, combined with a nickel cocatalyst, enable highly selective and scalable amine dehydrogenative coupling with hydrogen evolution.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Conventional hemodialysis devices are limited by their need for large dialysate volumes, which restricts portability. This study introduces a dialysate-free wearable artificial kidney prototype that uses gas-permeable, blood-repellent membranes for vapor-gradient-driven water removal and integrated adsorption for toxin clearance, offering a promising technology for portable blood purification.

HorusEye is a foundation model for universal X-ray tomography restoration that learns realistic degradation directly from data. It supports imaging at substantially lower doses and reduces hardware requirements while improving expert analysis and downstream AI performance.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

Laser shock experiments on an iron-water phase reveal its density, melting, and electronic changes under extreme pressures. The results suggest dense deep magma oceans and show that iron-water reactions can greatly shrink and densify super-Earths.

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

This study utilized a longitudinal cohort of adolescents to identify distinct brain signatures linked to ADHD symptom trajectories, revealing that specific cortical and subcortical changes correlate with symptom persistence, remission and emergence, enhancing predictive capabilities for ADHD outcomes.