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This study reports real-space, layer-resolved magnetic imaging of the van der Waals antiferromagnet (Fe,Co)₃GaTe₂ using SPLEEM, revealing A-type interlayer coupling, intrinsic chiral spin textures and enabling controlled writing of antiferromagnetic skyrmions.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

High-performance perovskite tandem solar cells are limited by uneven, disordered self-assembled monolayer (SAM) acting as hole-selective layers. Luo et al. design a SAM that yields uniform, stable interfaces, reducing non-radiative losses and boosting efficiency and durability

Recent experimental advances enable combinations of scanning tunneling microscopy with ultrashort pulses. Here, the authors demonstrate orbital-resolved probing of ultrafast exciton dynamics in single napthalocyanine molecules by means of a two-pulse wavepacket interferometric scheme. This shows site-dependent local coherences, unveiling the role of bright and dark states due to intermolecular interactions.

Yang et al. report a molecular confinement strategy that regulates self-assembled monolayer packing and stabilizes buried interfaces in inverted perovskite solar cells, enabling a power conversion efficiency of 26.84% with an 86.6% fill factor.

The authors report an asymmetric de Mayo reaction catalyzed by a chiral hafnium phosphate complex, enabling visible-light-promoted dearomatization and exoaromatic C–C bond insertion of salicylaldehyde derivatives with alkenes.

This study shows that maize hybrids exhibit increased transcriptome activity than inbred parents in an incomplete dominance manner, contributing to hybrid vigor. This increase is primarily regulated by transcription factors acting as trans-eQTLs.

Glycolysis has long been considered a process restricted exclusively to the cytoplasm. Here, the authors show that a functional glycolytic pathway operates inside mitochondria to maintain organelle health, identifying the VWA8-PHB2-GRP75 complex as a critical regulator that offers a promising therapeutic target for mitochondrial diseases like retinitis pigmentosa.

The authors revealed that defective sulfation of a cholesterol-derived metabolite drives harmful lipid buildup in cartilage cells, while the sulfated form protects against osteoarthritis.

Anthropogenic activities pose threats to riverine fish communities and result in reduced yields. However, this study shows that biodiversity and habitat complexity can buffer human impacts and help stabilize fish communities across spatial scales.

Despite the proven therapeutic efficacy, CAR T cell treatment carries the risk of severe toxicities. How sex-associated differences affect therapy-associated toxicities is underexplored. Here, the authors conduct a retrospective pharmacovigilant study using the FAERS database and highlight sex-associated differences in CAR T therapy complications, with females exhibiting a consistent pattern of increased adverse events across cancer types and therapy products.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

A spatial transcriptomic atlas of tissue from healthy people and people with inflammatory bowel disease evaluates spatial transcriptomics platforms, reveals Treg biology, and establishes a benchmark for applying spatial transcriptomics in translational research.

Here they assemble a cross-species single-cell transcriptomic atlas of mammalian placentas and show that trophoblast diversification underlies placental evolution, while identifying TGIF1 as a regulator associated with preeclampsia and pregnancy loss.

Chronic pain in pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. Here, the authors show that cancer-derived GDF15 drives the expansion of a specialized CCN3⁺ Schwann cell subpopulation, which in turn promotes sensory nerve sensitization and contributes to pain in PDAC.

This study identifies a mitochondrial protection pathway that safeguards mitochondrial DNA integrity and limits liver damage. Disrupting this pathway triggers inflammation and fibrosis, while restoring protection or inhibiting DNA sensing markedly ameliorates fatty liver disease.

Seawater electrolysis for green hydrogen is hindered by chloride-induced corrosion and local acidification of anodes. Here, the authors report an osmium-decorated cobalt phosphide anode that buffers protons and repels chloride, enabling stable ampere-level seawater electrolysis for 4500 h.

Btg2 suppresses UFMylation of Fmo1, promoting its k48-linked ubiquitination and degradation, thereby restricting taurine synthesis and exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury.

Optical neural networks (ONNs) are limited by unitary transformations and cumulative loss. Here, authors integrate programmable gain into time-synthetic ONNs to suppress feedback paths, which enables arbitrary complex-valued transformations and stable loss compensation for image classification.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

The authors report a polymer-templating strategy that accelerates perovskite nucleation through weak, reversible interactions, enables the growth of large single crystals, and offers a broadly applicable route to controlled crystallisation across halide perovskites.

The study reports on a peritectic engineering strategy to achieve enhanced electrical performance in InSb thermoelectrics. This material platform enables smart prosthetics with machine learning-assisted tactile sensing and messaging capabilities.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Hypoxia triggers distinct epidermal and dermal metabolic responses, driving skin organoids from spherical aggregates to planar embryonic-like structures. This reveals how cells use low oxygen to construct functional tissue.

How single-neuron network topology shapes neuronal function and learning remains unclear. By tracking thousands of neurons in monkey PPC across learning, the authors show that network topology at single-neuron resolution facilitates both global and modular neural processing to mediate task performance and learning.

The breast cancer intelligent non-invasive diagnosis system (BINDS) integrates multimodal medical imaging data for breast cancer risk assessment and subtype classification, improving diagnostics and reducing the need for biopsies of benign lesions.

Aerogels are promising for thermal insulation materials, though often have unfavorable mechanical properties. Here the authors design an aramid nanofiber aerogel to optimize mechanical and insulative properties.

Cell-free systems hold potential for nucleic acid assays but are limited by the need for pre-amplification. Here the authors develop a cell-free diagnostic platform that detects viral RNA without pre-amplification demonstrating uses on six respiratory viruses in under 70 minutes with attomolar sensitivity.

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

Analyzing spatial patterns and regulatory mechanisms in spatial multi-omics data remains challenging. Here, the authors present SpatialCOC, a deep learning framework that deciphers cellular spatial organization and cross-omics relationship.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

Controlling plant metabolism to improve growth and disease resistance has huge potential. Here, the authors find a conserved pathway which promotes antiviral resistance and promotes plant growth and develop polyglutamate-loaded chitosan nanogels to manipulate this pathway.

MiRNAs and natural antisense transcripts can both regulate gene expression and plant development. Here, the authors show that cis-NATs to MIR398 repress processing of pri-miR398 and that cis-NAT expression is downregulated at high temperatures, contributing to miR398 mediated thermotolerance responses.

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8⁺ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The authors report a 2D spin-LED based on CrSBr. Distinct from conventional circular polarization schemes, it actively transduces magnetic phase transitions into tunable electroluminescence, establishing a magnetic-order-modulated paradigm.

Molecular aggregates with photophysical behaviour have triplet excitons, but these are not well studied. Here, the authors report the study of triplet exciton behaviour in aggregates of various sizes, and the effect of this on photophysical behaviour.

Here, in mouse models of GMPPB dystroglycanopathy, the authors show that impaired glycosylation disrupts muscle integrity and triggers broader cellular stress. They identify actionable pathways that improve muscle function, suggesting therapeutic strategies.

Ventricular cardiomyocytes generate action potentials through multiple ion-mediated channels. Gao et al. replicate this process using artificial organic electrochemical cardiomyocytes, which respond to electrical or chemical modulation and synchronize with bioelectric signals of living cardiomyocytes.

Capacitive sensors based on electronic polarization typically exhibit low sensitivity as their dielectric modulation is confined to a single mode. Here, the authors develop a dielectric-gradient all-fiber non-ionic electronic skin that converts interfacial impedance into signal amplification for tactile sensing.