How the interaction between molecular motors and cargoes is regulated is not well understood. Liu and colleagues show that phosphatidylinositol-4-phosphate (PtdIns(4)P) dissociates the retromer component sorting nexin SNX6 from the p150Glued subunit of dynactin on retrograde transport vesicles docking at the trans-Golgi network. PtdIns(4)P is also shown to modulate the association of SNX4 and dynein on retrograde vesicles en route to the endocytic pathway.
- Yang Niu
- Cheng Zhang
- Jia-Jia Liu
