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The mechanical reliability and scalability of flexible perovskite solar cells remain challenging. Mingzhu He et al. design β-cyclodextrin derivatives to reinforce grain boundaries, enhancing both the efficiency and stability of cells and modules.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

This study provides a cellular atlas of A. annua glandular trichomes using single-nucleus and spatial transcriptomics. It defines three developmental states and identifies hundreds of hub genes for trichome morphogenesis and artemisinin synthesis.

This study reveals stage-dependent cognitive network dedifferentiation in early psychosis, with increasing inter-domain correlations from healthy controls to clinical high risk to first-episode schizophrenia, linked to reduced general intelligence.

Aberrant coagulation and thrombosis are associated with severe SARS-CoV-2 infection. Here, the authors show that the E protein are associated with coagulation disorders in COVID-19 patients and could directly enhance platelet activation and thrombosis through a CD36/p38 MAPK/NF-kB signaling axis.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

Allergic asthma is episodic and associated with seasonal changes which may have links with UV exposure levels. Here the authors propose a link between UVB exposure and ILC2 function through α-MSH released from the pituitary gland which accumulates in the serum and alters ILC2 function through the MC5R receptor.

A DNA molecular computation platform allows the rapid diagnosis of lung cancer with high accuracy by analysing specific miRNA levels in clinical serum samples.

The de novo construction of enantioenriched 3-hydroxyindolenines and 3-oxindoles from easily available starting materials is highly desired. Here, the authors demonstrate an enantioselectively intermolecular direct [3 + 2] annulation of aryl amine with 2,3-diketoesters to construct 3-hydroxyindolenines with a chiral tertiary alcohol.

Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with sarcopenia. In mouse models, they causally link BCAA catabolic dysfunction to impaired muscle mass and demonstrate the translational potential of enhancing BCAA catabolism.

Observation of single nascent RNA at single-nucleotide resolution enables building a conformation landscape of how RNAs change during transcription. Here the authors develop a method to monitor the conformational change of individual SAM-VI riboswitch RNA (riboSAM) during transcription at single-nucleotide resolution as it is synthesized by transcription.

Zhe Lu et al. reveal that phytoplankton taxa and seasonal changes shape ocean surficial carbon. Machine learning and satellite data show that diatoms dominate surface DOC, with more recalcitrant DOC produced during growth than decline seasons.

Large language models (LLMs) can be useful tools for science, but they often lack expert understanding of complex domains that they were not trained on. Zhang and colleagues fine-tuned a LLaMA-2-7b-based LLM with questions on organic chemistry reactions.

Platelets have been shown to alter immune cell function but it is not clear if this includes autoimmunity. Here the authors show that phosphatase and tensin homolog (PTEN) deficient platelets promote autoimmunity in mouse models through excessive activation of T_FH cells and systemic autoimmune pathology.

Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential to mice gametogenesis.

The strong modulation introduces coherent-multiple-transition into discrete time quantum walks in the frequency space, inducing topological band and fast quantum gate operations.

Inspired by the idea of mimicking virus entry to host cells and macrophage-mediated virus clearance, the authors developed a lysosomal “TRAP”, which could efficiently capture, internalize, and degrade viruses and variants.

By map-based cloning and knockout experiments, a study identified and validated ZmDMP to be one of the two genes known to control haploid induction in maize. A single-nucleotide mutation in ZmDMP causes a 2–3-fold increase in the haploid induction rate.

Using exome sequencing data from one of the largest cohorts of children with cerebral palsy, the genetic diagnostic rates of single-nucleotide and copy number variants were assessed and a sizeable fraction found to be clinically actionable.

Biohydrogen production technologies effectively use waste biomass resources and produce high-purity hydrogen. Here, authors present and evaluate a continuous pilot-scale biohydrogen production system based on spectrum coupling, thermal effect, and multiphase flow properties of hydrogen production.

During meiosis, chromosomes undergo dramatic changes in morphology and intranuclear positioning. Here the authors mapped the 3D genome architecture throughout mouse spermatogenesis by Hi-C of sorted cells to reveal the contributions of transcriptional activity and mechanical force in modulating homolog alignment and recombination.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

An inhalable, single-dose dry powder aerosol SARS-CoV-2 vaccine shows good storage stability, results in sustained antigen delivery to antigen-presenting cells in the lungs and induces a potent antiviral immune response.

Most recent SARS-CoV-2 variants showed exceptional immune evasion properties. Here, the authors identify a highly conserved epitope within the RBD targeted by a broad spectrum neutralizing antibody BA7535 that shows therapeutic antiviral potency in mouse studies.

The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.

MCR-1-positive Escherichia coli carriage in humans across China is associated with anthropogenic factors, including meat consumption and aquatic food production.

Radial spokes (RS) are crucial in coordinating ciliary motility. Here, authors use cryo-EM and cryo-ET to gain insight into mammalian RS divergence in ependymal cilia, RS assembly mechanism and the structure-function relationships of ciliary and flagellar axonemes.

Wang et al. clarify the regional heterogeneity of intestinal AMPs and identify that chromatin accessibility determines the potential of BATFs to regulate AMPs at the pre-transcriptional level, thus shaping the regional heterogeneity of AMPs.

p38α signaling promotes keratinocyte proliferation and psoriasis-related proinflammatory gene expression in psoriasis by activating STAT3, and further amplifies the IL-23/IL-17 pathogenic axis.

Predictive methods for gastric cancer to try and differentiate between potential treatment response are required. Here the authors use a multiplexed immunohistochemistry method to propose the proximity of tumour infiltrating immune cells as an indicator of likely therapeutic response.

Inflammation needs to be carefully controlled to prevent immunopathology. Zhou and colleagues demonstrate that the kinase MST4 dampens inflammation in a nonredundant way by targeting the activity of the key proinflammatory signaling molecule TRAF6.

Disrupting the interaction between telomere protein TRF1 with meiosis-specific protein TERB1 impairs the pairing of X and Y chromosomes via their telomere-adjacent pseudoautosomal regions in pachytene, leading to spermatocyte apoptosis and male infertility in mice.

The study presents a mobility centrality index to delineate urban dynamics in quasi-real time with mobile-phone data. The results indicate that urban structures were becoming more monocentric during the COVID-19 lockdown periods in major cities in Spain.

Mutations in the ZmDMP gene induce maternal haploids and facilitate breeding in maize. Now, a study extends this system of maize to dicots, showing that loss-of-function mutations in the Arabidopsis ZmDMP-like genes also induce maternal haploids.