Nature Search

Bio-orthogonal functionalization of bacterial cellulose combining metabolic glycoengineering and click chemistry

Bacterial cellulose (BC) possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical applications. Here the authors use glycoengineering–click chemistry to incorporate azide groups into BC in situ, and show enhanced BC-mediated wound healing.

Shaojie Chen
Hao Tang
Chao Zhong
ResearchOpen Access03 Feb 2026
Nature Communications

P: 1-14
High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

The 64-plex fluorescence imaging of RNA in tissues is achieved in one imaging cycle

Tianyi Chang
Shihui Zhao
Yanyi Huang
Research30 Oct 2025
Nature Biotechnology

P: 1-13
Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice

The role of outer mitochondrial membrane proteins in Myocardial Ischemia-reperfusion Injury (MIRI) largely remains unknown. Here, the authors demonstrate that the outer mitochondrial membrane protein Myocardial Mitochondrial Antiviral Signaling (MAVS) protein promotes MIRI suggesting MAVS protein as potential therapeutic target.

Zhenyu Kang
Mengling Yang
Desheng Hu
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-23
DiffDomain enables identification of structurally reorganized topologically associating domains

Topologically associating domains (TADs) are critical structural units in 3D genome organization, and their reorganization between health and disease states is associated with essential genome functions. However, computational methods for identifying reorganized TADs are still in the early stages of development. Here, the authors present an algorithm leveraging random matrix theory to identify reorganized TADs.

Dunming Hua
Ming Gu
Dechao Tian
ResearchOpen Access13 Jan 2024
Nature Communications

Volume: 15, P: 1-14
Machine learning models predict mortality risk in diabetic neuropathy patients using MIMIC-IV data

Yanyi Huang
Wei Mo
Jianlu Bi
ResearchOpen Access05 Nov 2025
Scientific Reports

Volume: 15, P: 1-16
A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design

The human leukocyte antigen (HLA) complex plays an important role in building an immune response, but it is hard to predict which peptides will bind to it. Chu et al. present a transformer-based approach to identify which peptides have a high binding affinity to HLA, a task that can also be translated to other binding problems.

Yanyi Chu
Yan Zhang
Dong-Qing Wei
Research23 Mar 2022
Nature Machine Intelligence

Volume: 4, P: 300-311
ProMENDA: an updated resource for proteomic and metabolomic characterization in depression

Juncai Pu
Yue Yu
Peng Xie
ResearchOpen Access30 May 2024
Translational Psychiatry

Volume: 14, P: 1-7
Living materials fabricated via gradient mineralization of light-inducible biofilms

Coupling light-inducible bacterial biofilm formation with hydroxyapatite mineralization enables the synthesis of living patterned and gradient composite biomaterials with control over the degree of mineralization and the ability to self-heal.

Yanyi Wang
Bolin An
Chao Zhong
Research21 Dec 2020
Nature Chemical Biology

Volume: 17, P: 351-359
Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis

microRNAs are known to be deregulated in cancer. Using a screen for microRNAs that alter cell migration, Zhanget al. show that mir-23b blocks cell migration in vitro and in vivoand is reduced in expression in human colon cancer, suggesting a therapeutic potential for this microRNA.

Hanshuo Zhang
Yang Hao
Jianzhong Jeff Xi
ResearchOpen Access22 Nov 2011
Nature Communications

Volume: 2, P: 1-11
Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma

The functional role of transposable elements (TEs) in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors identify a liver-TE/KDM1A/HNF4A regulatory axis that promotes HCC growth and suggest therapeutic targeting of KDM1A.

Tiantian Jing
Dianhui Wei
Boshi Wang
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-21
Highly accurate fluorogenic DNA sequencing with information theory–based error correction

The error rate of DNA sequencing is much reduced by combining an improved fluorogenic sequencing chemistry with a new error-correction scheme.

Zitian Chen
Wenxiong Zhou
Yanyi Huang
Research06 Nov 2017
Nature Biotechnology

Volume: 35, P: 1170-1178
0.26-Hz-linewidth ultrastable lasers at 1557 nm

Lifei Wu
Yanyi Jiang
Longsheng Ma
ResearchOpen Access27 Apr 2016
Scientific Reports

Volume: 6, P: 1-5
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus

Xiangyu Chen
Qinji Zhou
Peng Xie
ResearchOpen Access06 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-10
Characterizing metabolomic and proteomic changes in depression: a systematic analysis

Juncai Pu
Yiyun Liu
Peng Xie
Research15 Feb 2025
Molecular Psychiatry

Volume: 30, P: 3120-3128
Materials design by synthetic biology

Materials synthetic biology merges synthetic biology with materials science for the redesign of living systems into smart materials. This Review discusses how synthetic-biology tools can be applied for the engineering of self-organizing functional materials and programmable hybrid living materials.

Tzu-Chieh Tang
Bolin An
Chao Zhong
Reviews23 Dec 2020
Nature Reviews Materials

Volume: 6, P: 332-350
Reconstruction of Dynamic and Reversible Color Change using Reflectin Protein

Tiantian Cai
Kui Han
Can Xie
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
The therapeutic potential of circular RNAs

Circular RNAs have gained attention for their stability, immunological advantages and regulatory functions, making them a promising modality in multiple therapies. This Review discusses the therapeutic prospects of circular RNA-based approaches and the emerging role of circular RNAs as biomarkers in disease.

Eoghan O’Leary
Yanyi Jiang
Jørgen Kjems
Reviews09 Jan 2025
Nature Reviews Genetics

Volume: 26, P: 230-244
High-throughput single-cell whole-genome amplification through centrifugal emulsification and eMDA

Yusi Fu, Fangli Zhang et al. integrate a one-step microcapillary array with emulsion multiple displacement amplification to obtain a high-throughput single-cell whole-genome amplification method. Their method enables copy number assessment at a resolution of 50 kb.

Yusi Fu
Fangli Zhang
Jianbin Wang
ResearchOpen Access29 Apr 2019
Communications Biology

Volume: 2, P: 1-10
High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

This study describes the construction of a focused CRISPR/Cas-based lentiviral library in human cells and a method of gene identification based on functional screening and high-throughput sequencing analysis.

Yuexin Zhou
Shiyou Zhu
Wensheng Wei
Research09 Apr 2014
Nature

Volume: 509, P: 487-491
Use of antimicrobial peptides as a feed additive for juvenile goats

Qi Liu
Shuhua Yao
Shumin Yu
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
H3K4me3 epigenomic landscape derived from ChIP-Seq of 1 000 mouse early embryonic cells

Jie Shen
Dongqing Jiang
Yanyi Huang
CorrespondenceOpen Access02 Sept 2014
Cell Research

Volume: 25, P: 143-147
Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9

YongHao Li
Xiong Liu
Weiyi Fang
ResearchOpen Access18 Nov 2019
Signal Transduction and Targeted Therapy

Volume: 4, P: 1-12
The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice

Xiaoyu Hu
Jian Guo
Naisheng Zhang
Research27 Apr 2020
The ISME Journal

Volume: 14, P: 1897-1910
Systematic evaluation of a ¹⁷¹Yb optical clock by synchronous comparison between two lattice systems

Qi Gao
Min Zhou
Xinye Xu
ResearchOpen Access22 May 2018
Scientific Reports

Volume: 8, P: 1-8
Lipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy

Our work contributes to synthesize a vehicle based on lipid nanoparticles, which can effectively deliver Cas9/sgRNA-fused plasmid DNA in vitro and in vivo. This approach mediated successful transfection of Cas9/sgRNA plasmids in multiple cell lines in vitro. The vehicle carrying Cas9/sgRNA targeting PLK-1 resulted in significant down-regulation of PLK-1 protein and suppression of melanoma growth in vivo.

Lingmin Zhang
Peng Wang
Xingyu Jiang
ResearchOpen Access27 Oct 2017
NPG Asia Materials

Volume: 9, P: e441
Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

Lu Wen
Jingyi Li
Jirun Peng
ResearchOpen Access30 Oct 2015
Cell Research

Volume: 25, P: 1250-1264

Search

Bio-orthogonal functionalization of bacterial cellulose combining metabolic glycoengineering and click chemistry

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice

DiffDomain enables identification of structurally reorganized topologically associating domains

Machine learning models predict mortality risk in diabetic neuropathy patients using MIMIC-IV data

A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design

ProMENDA: an updated resource for proteomic and metabolomic characterization in depression

Living materials fabricated via gradient mineralization of light-inducible biofilms

Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis

Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma

Highly accurate fluorogenic DNA sequencing with information theory–based error correction

0.26-Hz-linewidth ultrastable lasers at 1557 nm

TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus

Characterizing metabolomic and proteomic changes in depression: a systematic analysis

Materials design by synthetic biology

Reconstruction of Dynamic and Reversible Color Change using Reflectin Protein

The therapeutic potential of circular RNAs

High-throughput single-cell whole-genome amplification through centrifugal emulsification and eMDA

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

Use of antimicrobial peptides as a feed additive for juvenile goats

H3K4me3 epigenomic landscape derived from ChIP-Seq of 1 000 mouse early embryonic cells

Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9

The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice

Systematic evaluation of a ¹⁷¹Yb optical clock by synchronous comparison between two lattice systems

Lipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy

Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

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