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Superionic conductors are typically engineered from static crystal structures. Here, authors present how flexible polyanion rotations induce dynamic disorder in lithium sublattice, enabling liquid-like ion diffusion and enhanced ionic conductivity.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Pyomelanin is resistant to UV light, and has antibacterial and anti-inflammatory effects, however, the yield of pyomelanin isolated from natural producers is low. Here the authors engineer Komagataella phaffii to produce 70.5 g/L and isolate the product.

Alumina (Al₂O₃)-bearing minerals are hosted in carbonate-rich sediments, potentially interacting with CaCO₃ during subduction. Here, the authors study the influence of Al₂O₃ particle size on carbonate stability at 0.5–2.8 GPa and 350–1050 °C, showing that CaCO₃ remains thermodynamically stable when coexisting with micron-sized Al₂O₃ and Al(OH)₃, whereas Al₂O₃ nanoparticles trigger decarbonation, forming CaAl₄O₇, CO₂, and trace graphite.

Lithium–sulfur batteries are a promising electrochemical energy storage technology; however, they are limited by the dissolution of polysulfide intermediates. Now, it has been shown that sparingly solvating electrolytes containing a phase mediator can avoid polysulfide dissolution and accelerate surface-localized solution-phase sulfur reaction to improve battery performances.

Lithium dendrite growth and liquid electrolyte volatilization limit the further development of lithium-oxygen batteries. Here, authors report a non-Newtonian fluid quasi-solid electrolyte to address those issues, which improve the life duration of the lithium-oxygen batteries.

Iridium oxide is a state-of-the-art catalyst for green hydrogen production, but the identity of species present under operating conditions remains debated. Here, using multiple operando spectroscopy approaches with time-resolution, water oxidation is found to be driven by O⁻¹ states.

Achieving efficiency by approaching the theoretical limit in silicon heterojunction solar cells remains challenging. Here, the authors fabricate devices using rear-side polishing and progressive RF/VHF PECVD film deposition schemes for doping layers, realizing a certified cell efficiency of 27.0%.

Eye tracking relies on ocular features, that are susceptible to interference from light and individual variations. Here, Zhu et. al. present eye movement feature enhanced cosmetic contact lenses, enabling accurate, natural, and homogenized eye tracking.

Dysfunctional NK cells contribute to the immune-hostile tumour microenvironment of triple-negative breast cancers (TNBC). Here authors show that NKSM, a micropeptide encoded by the long non-coding RNA UGDH-AS1, is specifically expressed in the intra-tumoral NK cells in TNBC and interferes with their anti-tumour activity.

Femtosecond X-ray solution scattering reveals how solvent environments direct the outcome of ultrafast roaming reactions in bromoform, determining whether transient hot isomers undergo rapid solvolysis or rearrange into long-lived isomeric products.

Lattice-oxygen redox is pivotal for high oxygen evolution reaction (OER) activity. Here, LiNiO₂, a unary 3d-transition metal oxide catalyst, exhibits superefficient activity during the OER due to the creation of double O 2p holes states, according to operando XAS, XRD, and Raman spectroscopy observations.

Extracting high-purity salt from saline water through conventional processes is complex and environmentally unsustainable. A diffusion-driven selective crystallization strategy that uses a precisely designed floating porous membrane to suppress non-ion-selective transfer enables simple and precise ion separation and high-purity salt production from mixed source solutions such as Na⁺/K⁺, Ba²⁺/K⁺ and Mg²⁺/Li⁺.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

An engineered self-assembled monolayer improves perovskite crystallization, enabling perovskite–silicon tandem solar cells with a certified power conversion efficiency of 33.59%, 90% of which is maintained after 2,000 h of operation at ambient temperature.

DNA in many bacteriophages contains unusual chemical modifications. Here, the authors discover that carboxymethylcytosine is a natural DNA base and reveal its role as an intermediate enabling further DNA hypermodification.

Biological invasions reshape competition within and between species. This global meta-analysis shows that competition reduces trait means and increases trait variation, with stronger impacts of nonnatives on natives.

A universal design strategy for nanograined metals aimed at utilizing oxygen nanoclustering to achieve the highly desired combination of high strength and large deformability that evades inverse Hall-Petch softening.

Interwoven magnetic and non-magnetic layers in TbTi₃Bi₄ overcome kagome frustration, producing coupled elliptical-spiral magnetic and spin-density-wave orders and a very large anomalous Hall effect driven by strong electron–magnetic field interactions.

A new form of momentum-selective electron energy-loss spectroscopy enables the element-resolved imaging of frequency- and symmetry-dependent vibrational anisotropies with atomic resolution.

Polygenic Risk Scores (PRS) show promise for facilitating cancer risk stratification. Here, the authors performed a large genome-wide association study and develop a PRS for nasopharyngeal carcinoma, which could improve risk stratification and personalized screening.

De novo genome assembly and analyses of 12 maize FILs provide insights into genomic and phenotypic differentiation of various heterotic groups and the molecular basis of heterosis in maize.

Jiang and colleagues identify ETV7 as a transcriptional node that skews CD8⁺ T cell transcriptional profiles toward exhaustion, consequently limiting antiviral and antitumor efficacy, and show that it can be targeted in CAR T cells to enhance efficacy.

It is important to understand cellular uptake of nanoparticles, but the effects of cell cycle and autophagy are underexplored. Here, the authors construct a multi-functional, multi-dimensional platform, and use this to characterise the effects of cell cycle- and autophagy-associated cellular accumulation of clinically used lipid-based nanoparticles.

During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells.

The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.

Photoredox catalysis is an important approach for synthesizing fine chemicals from olefins, but the limited lifetime of radical cation intermediates severely restricts the efficiency. Here, the authors report that Ag3PO4 can efficiently catalyze intramolecular and intermolecular [2 + 2] and Diels–Alder cycloadditions under visible-light irradiation.

Great progress has been made in the development of bifunctional oxide-zeolite catalysts to tackle the selectivity challenge in syngas chemistry. Here the authors show syngas conversion can be steered along a highly active and selective pathway towards light olefins via ketene acetate (acetyl) intermediates.

Materials with higher-order multistates are desired for non-Boolean high-density storage. Here the authors realized sextuple intrinsic polarization states in vdW CuInP₂S₆, and reversible transformation among sextuple-, quadruple-, and double-polarization orders.

The C2 sulfonates taurine and isethionate are also present in the anaerobic mammalian gut, where they are converted into toxic H₂S by sulfate and sulfite-reducing bacteria. Here the authors characterise the O₂-sensitive enzyme IseG that catalyzes the C-S bond cleavage of isethionate and show that IseG also plays a key role in converting taurine into H₂S in Bilophila wadsworthia.

Small size, precise steering, and visualized functional treatment are crucial for robotic interventional diagnosis and treatment. Here, the authors introduce a fiberscopic robot which integrates maneuvering, imaging, and biomedical operation abilities in the sub-millimeter scale

Hydroxylation at the C-14 position of triptolide is critical for its potent antitumor activity. Here, the authors report two CYP82Ds catalyze the 14-hydroxylation reaction via metabolic grid and achieve heterologous bioproduction of triptolide precursor in engineered Saccharomyces cerevisiae.

The authors fabricate highly (00l) orientated Bi₂Te₃-based films by liquid Te assistant growth method, showing high mobility stemming from high orientation and low lattice thermal conductivity, resulting from excess Te induced staggered stacking faults.

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

In a large prospective cohort of 1,090 pregnant women with a high risk of fetal genetic diseases, a cell-free DNA screening identified cases of aneuploidies, microdeletions and monogenic variants with high accuracy in concordance to standard diagnostic tests

A genome-wide association analysis using data from Chinese individuals combined with a transethnic meta-analysis of Psychiatry Genomics Consortium data identifies 30 new loci for schizophrenia. These analyses improve the fine-mapping of susceptibility loci and implicate multiple pathways in schizophrenia biology.