In fasted mammals, circulating pancreatic glucagon stimulates gluconeogenesis in the liver in part through the CREB coactivator CRTC2. The production of glucose by the liver is increased in obesity, reflecting chronic increases in endoplasmic reticulum (ER) stress that promote insulin resistance. Here, CRTC2 is shown to function as a dual sensor for fasting signals and ER stress, thereby contributing to glucose homeostasis.
- Yiguo Wang
- Liliana Vera
- Marc Montminy
