Search

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Single-photon emitters have been demonstrated in many wide-bandgap semiconductors and offer strong potential for quantum technology applications. Here the authors demonstrate room-temperature single-photon emission from β-gallium oxide, an emerging wide-bandgap semiconductor, opening new directions for research.

Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner. Disrupting the HDAC1 condensates with resminostat restores the sensitivity to temozolomide.

A breakdown of the tight coupling between Antarctic and subarctic productivity is identified during the Last Interglacial, likely due to the Southern Hemisphere westerlies, sustaining high CO₂ and potentially impacting future climate.

Profiling host RNA shed in feces reveals disease states in the gut.

Here, the authors identify a methane-consuming human gut bacterium, Methylocystis intestini, showing it can affect digestion and fat metabolism by regulating gut methane levels, revealing a natural gut microbial potential mechanism helping maintain healthy gut function and balance.

A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.

Developing high-current-density catalysts is key to efficient water splitting. Here, the authors report a single-atom Ru-doped amorphous Ni–Mo oxide that dynamically self-reconstructs to retain high activity at industrial current densities in an anion-exchange membrane water electrolyzer.

A severe acute respiratory syndrome coronavirus 2 Omicron subvariant, BA.2.86, was found to be no more resistant to human sera than the currently dominant XBB.1.5 and EG.5.1, but it had a remarkably higher receptor affinity.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

The authors find low-energy magnetic excitations and a flat band near the Fermi level in kagome metal superconductor CsCr3Sb5 by angle-resolved photoemission and resonant inelastic X-ray scattering. They suggest that the flat band plays a role in the emergence of charge/magnetic order at low temperatures.

CRISPR activators are powerful tools for controlling gene expression, but they suffer from inconsistent efficacy and high toxicity. Here, authors develop a high-throughput method to test thousands of CRISPR activators, revealing distinct principles of activator biology and delivering improved tools.

Recent studies have traced haematopoiesis at the clonal level but lack a way to extract dynamical information. Here, authors develop CLADES, a tool to estimate cellular kinetics and the number of divisions to produce mature cells for each clone, in human cord blood and adult mouse haematopoiesis.

Aqueous-hydrotrope hybrid liquid electrolyte solutions enable overcoming the electrochemical stability window and operational temperature limits of aqueous electrolyte solutions in secondary zinc-based batteries, also improving the battery performance.

scTranslator is a large-scale generative model that translates single-cell transcriptomic data to proteomic data and can assess the impact of gene perturbation on protein levels.

Controllable electric transport of topological particles in solid state systems hold the key towards novel electronic applications. Here, Wang et al. demonstrate gate-tunable negative longitudinal magnetoresistance in WTe₂, featuring controllable transport of Type-II Weyl fermions.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

The relationship between pancreatic β-cell dysfunction and autoinflammation in T2DM is unclear. Here, the authors show the key role of a UCP2/mtDNA/STING axis in the IL-1β induced autoinflammation cycle in T2DM and develop Mito-G, a highly efficient mitochondria targeting nanodrug to treat T2DM.

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and improve long-term cardiac function via transient IRF7 inhibition.

This work introduces roll-to-roll fluidics, a method that enhances reagent efficiency and reduces turnaround time, enabling rapid and economical next-generation sequencing.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Psoriasis is a skin disease associated with neurogenic inflammation. Here, the authors activation of ASIC3 on sensory neurons that leads to the release of CGRP, which triggers inflammation through dendritic cells and drives psoriatic inflammation.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

Precise separation of ions with similar valence and size is critical. Here, authors designed a selective membrane that precisely extract Li+ from Na+ and Ca²⁺ interferences. The high selectivity and permeability enable energy-efficient, precise, and chemical-free lithium extraction using the electrodialysis process.

Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

The B.1.1.529/Omicron variant of SARS-CoV-2 is resistant to neutralization by serum not only from patients who recovered from COVID-19, but also from individuals vaccinated with one of the four widely used COVID-19 vaccines.

The precise control and transition between multiple stochiometric phases is challenging. Here, the authors grow and characterize four wafer-scale stoichiometric phases of a Pd-Te binary compound through a sequential multi-step nucleation process.

A self-transmissible CRISPR-associated transposase system encodes a nanobody payload to treat Shiga toxin infections.

Live-cell imaging and proximity labeling face limits in tracking protein dynamics. Here, the authors present SeeID, a NIR-activated method using SiR as a photocatalyst, enabling precise intracellular labeling, organelle- and disease-relevant interactome mapping, and deep-tissue studies in vivo.

NCOMMS-23-46799C Keratoconus can be effectively stabilized by corneal crosslinking (CXL), but the depletion of stromal oxygen limits the efficiency of CXL photochemical reactions. Here the authors address this issue by developing biocompatible graphitic carbon nitride quantum dots- based oxygen self-sufficient platforms.

Forest fragmentation by urban expansion creates plumes that enhance ozone production, according to analyses of combined field observations and modelling over South China.

Virtual reality technologies need olfactory systems to improve human perception, but their bulky formats limit their practicality. Here, Liu et. al. report flexible and miniaturized odor generators with tunable odor concentration in close user proximity for immersive virtual reality applications.

MEGAA, an efficient template-guided method to synthesize high-fidelity DNA variants

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

This study reveals that Holocene drying-induced woody plant expansion in peatlands suppresses microbial heterotrophic activity and enhances organic matter stability, creating a natural buffer for carbon storage under climatic stress.

The haptic interface is an essential part of human–machine interfaces where tactile information is delivered between human and machine. Yao et al. develop a soft, ultrathin, miniaturized and wireless electrotactile system that allows virtual tactile information to be reproduced over the hand.