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Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and organ dysfunction. Here, the authors show that lipid nanoparticles co-loaded with polydopamine and NUAK1 can reduce oxidative stress and inflammation, improving placental function and fetal growth in a preeclampsia mouse model.

Authors develop a general paradigm combining fluorescence resonance energy transfer imaging, gel electrophoresis and mass spectrometric analysis to identify and quantify intracellular N-acetylglucosamine modified glycoRNAs.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

Self-healing materials typically suffer from poor mechanical properties due to the inherent trade-off between mechanical robustness and self-healing capability. Here the authors report a composite featuring an aligned array of hydroxyapatite nanowires interwoven with dynamic borate bond networks by a bidirectional freeze-drying method.

Oxidative stress and dsRNA are key drivers of skin inflammation, while therapies targeting oxidative stress are common, dsRNA targeting is not. Here, the authors report on a cerium-doped polyoxometalate with anti-oxidative and dsRNA binding properties showing potential for a transdermal strategy to reduce skin inflammation.

Zhang et al. report a multifunctional molecule to control the growth of quasi-2D perovskite nanocrystals, reducing defects and ion migration. This enables pure-red LEDs with an efficiency of 30.2%, operational stability of 8426 min, and 12.25 cm² devices maintaining above 20% efficiencies.

Dysregulated CD59 drives uncontrolled complement activation in neuromyelitis optica spectrum disorders (NMOSD). Here, the authors show in a mouse NMOSD model that endothelial SPARC suppresses astrocytic CD59 by blocking the VEGFA/VEGFR2 axis, promoting astrocytopathy, that might offer a potential therapeutic strategy.

The authors reveal a two-stage formation of density-wave order in nickelate La4Ni3O10 at ambient pressure. First, a short-range charge order develops in the inner Ni-O layer, accompanied by a dramatic enhancement of spin fluctuations, followed by fully-developed charge and spin orders at lower temperature.

Accurately perceiving object softness remains challenging for tactile sensors. Here, the authors present a tactile sensor that quantitatively and accurately detects both Young’s modulus and Poisson’s ratio.

Human coronavirus HCoV-OC43, a prevalent cause of the common cold, shows differences between clinical isolates and tissue culture-adapted strains, raising concerns about the latter’s validity as a model. Here, the authors find that clinical isolates possess unique spike protein features affecting carbohydrate-binding properties, suggesting shared adaptation mechanisms with HCoV-HKU1 to the human sialoglycome.

Tang et al. demonstrate that disease progression in Duchenne muscular dystrophy is driven not only by dystrophin deficiency but also by ANXA11-mediated failure of regenerative myofiber maturation. Targeting ANXA11 improves muscle regeneration and function in mdx mice.

Polymeric nanoparticles are promising non-lipid-based drug delivery vehicles. However, their clinical translation is limited by poor drug loading capacity and suboptimal delivery efficiency. Here, the authors address these issues by developing Polymeric Coacervate Core Micelles that can efficiently self-assemble and load drug candidates via a “Mix-and-Go” approach.

Amorphous chalcogenides enable ultrafast threshold switching, yet their switching mechanism remains debated between electronic and structural models. Song et al. reveal an electric field induced atomic displacement and dipolar ordering, which exhibit a non-Arrhenius structural transition and guide conductive filament formation.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Bioelectric stimulation needs compact implantable power sources. Here, the authors develop a mechanochemically activated CNT/PVA micro-supercapacitor enabling high energy density and sustained intestinal stimulation, promoting internal wound repair

Nasopharyngeal carcinoma (NPC) screening in southern China uses EBV serology, but its positive predictive value is low. Here, the authors introduce a swab-based E-CpMQ method in high-risk individuals, achieving better specificity.

Resistance to targeted therapies in cancer can be induced by metabolic rewiring. Here, the authors show that upregulation of the glucose transporter GLUT6 drives targeted-therapy resistance by diverting glucose metabolism to activate the anti-oxidative stress NRF2 pathway in lung cancer.

The incorporation of metal single-atom into covalent organic frameworks facilitates co-reactant activation and charge transport enhancing electrochemiluminescence, however, can also trigger intramolecular electron transfer quenching that degrades the electrochemiluminescence efficiency. Here the authors achieved the coordination of silver atom into pyrene phenanthroline covalent organic frameworks, breaking the catalysis-quenching dilemma of metals and thereby achieving enhanced electrochemiluminescence performance.

A ZnO/CuO catalyst featuring dual-site cooperative framework for polymerization-based wastewater treatment. Zn sites preferentially adsorb/activate organics, whereas Cu sites predominantly activate the oxidant, showcasing atomic-scale design to reactor-scale implementation.

Flexoelectronic materials are promising for devices and electronics, but biomaterial based electronics remain underexplored. Here the authors investigate a wood-based flexoelectric material for sensors and devices.

Despite the global prevalence of SARS-CoV-2 infection, its maternal–fetal interface during the first trimester remains underexplored. Here, the authors combined a cohort of 700+ samples and determine that maternal SARS-CoV-2 infection in the first trimester rarely infects placental tissue but alters immune responses and cellular communication, which may influence pregnancy outcomes.

This study reveals how plants balance growth with survival under low-oxygen conditions. The signaling module SnRK1–RAP2.4h–PIP2 fine-tunes this trade-off, offering a potential target to improve crop flood tolerance.

A macrolide resistant Bordetella pertussis lineage (MT28) carrying a high-virulence allele (ptxP3) has been reported as a predominant lineage in China. Here, the authors show that MT28 has enhanced colonization and inflammatory characteristics.

The authors develop a polyvinylidene fluoride and mica bimorph to enhance pyroelectric response. The secondary pyroelectric contribution employs interfacial thermal stress to improve the pyroelectric performance for flexible electronics.

An Sb₂O₃ interlayer at the perovskite/electron transport layer interface increases the reverse-bias resistance of the cells to −22.3 V. Modules with an area of 62.37 cm² achieved a certified power conversion efficiency of 23.1%, 96% of which was maintained after 1,000 h of operation at 65 °C.

Oocyte-specific isoforms play crucial roles in oocyte maturation. This study utilizes single-cell full-length isoform sequencing to unveil the diversity of RNA isoforms, as well as TE co-option for novel isoform generation and isoform stability during human and mouse oocyte maturation.

Oleaginous microalgae can grow in wastewater and have potential applications in biotechnology and bioremediation. This analysis of the genomes of 38 strains of Scenedesmaceae reveals that horizontal gene transfer and diploidy likely fostered evolution of their unique properties and survival under stress.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Cation migration plays a critical role in the evolution of perovskite electrodes but is not fully understood. Here, the authors combine theory and experiment to show that cation migration coupled with phase segregation forms a highly active nanocomposite electrode.

Capturing RNA-protein interactions is vital for understanding cellular regulation but remains technically challenging. Here, the authors develop CuCLIP-seq, a sensitive, chemical-crosslinking method that accurately identifies diverse RNA substrates, including low-abundance targets.

Host defense requires coordination between epithelial sensing and systemic responses. Here, the authors show that proton signaling links intestinal pathogen detection to motor neurons, promoting avoidance behavior and innate immunity in C. elegans.

This study uses genome-wide screening and mouse genetics to uncover how cells control proinsulin, identifying the Golgi as a central hub and revealing PDIA6 as a key regulator of proinsulin production in pancreatic β-cells.

Here authors present a method combining DFT calculations with experimental synthesis to address the challenges of slow recovery and limited recyclability in chemiresistive sensing MOFs.

Lei et al. demonstrate that a rhizobial effector NopZ is phosphorylated by a symbiotic receptor kinase, leading to its enrichment in the nuclear/perinuclear region and promoting soybean nodulation.

A Drosophila secretome atlas identifies the tissue origins of circulating proteins, revealing unusual sources, uncharacterized proteins, ectodomain shedding, and candidate mediators of inter-organ communication.

UK BioCoin is a framework that efficiently generates customized GWAS results without individual data. It is validated through various applications as a promising privacy-preserving paradigm for large-scale biobank studies.

Electronic skins are capable to monitor stimuli such as temperature and pressure, though they are susceptible to crosstalk diminishing sensitivity. Here the authors report a mechanically and electronically hybrid network using vanadium oxide and liquid metal particles to optimize selectivity and sensitivity.

USP30, a negative regulator of mitophagy, is identified as a potential therapeutic target for lung fibrosis and viral pneumonia. Inhibition of USP30 protects alveolar epithelial cells from apoptosis and enhances alveolar regeneration.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The ability to diagnosing and differentiating intracerebral hemorrhage from ischemic stroke is clinically needed. Here, the authors report on a rapid blood test which analyses protein signatures from 90-180 nm extracellular vesicles for prehospital diagnosis.

Fe-based metallic glasses are reported as efficient oxygen scavengers, achieving removal rates 1–4 orders of magnitude higher than conventional systems through rapid adsorption and autocatalytic effect, while approaching theoretical capacity limits.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Hypothalamic POMC neurons are critical for energy balance. Here, authors show that TOX3 in these neurons regulates metabolism by promoting PTEN degradation and AKT activation, enhancing thermogenesis to protect against obesity.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Here, in mouse models of GMPPB dystroglycanopathy, the authors show that impaired glycosylation disrupts muscle integrity and triggers broader cellular stress. They identify actionable pathways that improve muscle function, suggesting therapeutic strategies.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.