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In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Here, the authors show that residues N490 and M492 of Hepatitis E Virus capsid protein are pivotal, albeit not exclusive, host tropism determinants of hepatitis E virus (HEV) for swine infection, which enhance the understanding of HEV’s zoonotic transmission and host specificity.

The study demonstrated that some exogenous natural polysaccharides could be absorbed in plasma with little degradation after orally administration. Polysaccharide uptake in the intestinal cells relied on clathrin/dynamin 1/Rab5-dependent endocytosis.

Diagnosing breast cancer through MRI is limited by high false-positive rates and inter- reader variability, leading to unnecessary biopsies. In here, the authors find that the BI-RADS 4 Lesions Analysis System (BL4AS) model improves diagnostic accuracy and reduces unnecessary biopsies as well as inter-reader variability

Coupling two ionic thermoelectric effects in n-type materials is scarce, restricting the development of high-performance systems. Here, the authors present an ionic-thermoelectric material with interactive thermo-diffusion/galvanic coupling effect based on coordination chemistry.

In this study, authors reveal an evolutionary strategy in bacteria, where multidrug resistance are stably maintained through multicopy heterogeneous genes on a single plasmid, conferring an adaptive advantage under fluctuating clinical drug pressures.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Zhai et al. report newly designed self-assembled molecules exhibiting strong and ordered anchoring on the perovskite surface to reduce defects and modulate the dipole-induced energy-level, enabling certified efficiencies of 26.23% in a normal device structure, which are also applicable to inverted perovskite solar cells.

The interplay between microglial phagocytosis and function is not completely understood. Here, the authors show that in response to neurodegeneration, the phagocytic receptor MerTK in microglia triggers PU.1 and IRF8, which elicit TGFβ1 as an autocrine signal. This signaling pathway also occurs in Alzheimer’s disease mouse model and patient cells.

Enhancing the selectivity of molecular recognition within (photo)-electrochemical systems has consistently presented a challenge. Here, the authors report a dark-enhanced photoelectrochemical mechanism for the highly selective quantitative analysis of glutathione on a BiOBr photocathode.

Circulating N-glycomics studies have shown alterations in multiple cancer types. Here, the authors show that blood-based glycome patterns on proteins can be used to predict liver damage and liver cancer development.

This study demonstrates that the Drosophila proventriculus, the structure at the anterior of gut that synthesizes the peritrophic membrane, lacks stem cells but undergoes continual endocycling to compensate for cells loss during aging or damage.

Organic molecular crystals with controllable bending angles are crucial interconnectors in integrated optoelectronic chips but current methods of tailoring bent geometric features in molecular crystals without fracturing remain limited. Here the authors proposing a molecular cocrystal strategy that introduces directional non-covalent interactions into molecular systems to weaken the original interactions triggering the spontaneous deformation.

Conventional organic polymeric resists and chemical solutions used in microlithographic techniques can damage sensitive materials. Here, the authors report the application of inorganic selenium molecules as a lithographic mediator and encapsulation layer during the processing of various sensitive materials, such as perovskites and black phosphorus.

The mechanisms and kinetics behind the anti-sintering behavior of supported metal nanoparticles under ultrafast heating remain unclear. Here, in situ scanning transmission electron microscopy and theoretical analysis reveal an ultrafast-heating–induced metastable state that suppresses thermal sintering while enhancing crystallinity of the metal nanoparticles and their interfaces.

Acute-on-chronic liver failure is a complex condition with varied definitions. Using unbiased clustering, the study identifies two distinct subtypes with markedly different 30-day mortality risks and highlights key determinants.

Ma et al. report an organic cation engineering strategy to improve the luminescent properties and charge transport in organic-inorganic antimony halide films, enabling red LEDs with efficiency up to 19.4% and half-lifetime of 10,190 min. Large-area (12.15 cm²) LEDs show efficiency of 14.2%.

Mouse models show that lymphoedema caused by impaired lymphatic drainage is ameliorated by removal of cholesterol deposits, which promotes the regeneration of lymphatic vessels.

The molecular heterogeneity of brain metastases (BrMs) poses challenges for their treatment. Here, the authors generate a multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer BrMs and identify four molecular subtypes with distinct biological and clinical features.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A graph-based pangenome constructed from 39 reference-quality genomes of wild and cultivated cucumber accessions, including 27 newly assembled, highlights the dynamics of structural variants during cucumber domestication and range expansion.

Systemic flavivirus dissemination in mosquitoes following initial infection requires protein–protein interactions within extracellular vesicles, which enable infectious particles to be transported through haemolymph and confer species specificity.

A platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Operating a photonic chip that integrates quantum dots with lithium niobate resonators at an exceptional point allows for spontaneous single-photon emission with an exceptional-point-induced transparency window, a squared-Lorentzian line shape or a Fano-asymmetric line shape.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

A drug repurposing strategy identified fluvastatin as a CYP4Z1 inhibitor with a potential to inhibit the initiation and metastasis of breast cancer in vitro and in vivo.

Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

DNA methylation and gene expression data integration identify aging-related genes in blood that predict health outcomes, offering new insights into aging biology and potential therapeutic targets.

Shang, Zhao, Ying and colleagues report that the mechanosensor PIEZO1 senses blood shear stress in hematopoietic stem cells, driving proliferation and myeloid bias. This axis links mechanical force to inflammation-induced aging, and PIEZO1 emerges as a potential therapeutic target.

This study uncovers genetic links between plant roots and their microbiome in Brassica napus, identifying microbe-associated loci and a beneficial bacterium, Sphingopyxis, that promotes nitrogen uptake.

The molQTLs of porcine peripheral blood mononuclear cells and neutrophils provide insights into the regulatory mechanisms of immune traits.

This study reports that genomic signatures composed of the loss of pluripotency inhibitors, expansion of pluripotency activators and maintenance of an epigenetically permissive state contribute to the plantlet formation in Kalanchoe.

Amplification and optimal noise filtering in hyperpolarized noble-gas spins of observations from distributed intercity quantum sensors monitoring for unexpected transient rotations of polarized spins set parameter range constraints in the search for axion dark matter.

A widely applicable, cost-effective, easily accessible and handleable, highly active, and recyclable d3-methylation reagent remains has not yet been reported. Here, the authors design a thianthrene-based organic polymer that shows the ability of capturing and releasing a d3-methyl reagent.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.