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In animals, H3K4me1 marks enhancers. Here the authors show that in land plants H3K4me1 is recognized by a specific reader protein, which interacts with an H3K36 methyltransferase, to direct the establishment of H3K36me2 and H3K36me3.

Traditional solution- and vacuum-deposition may leave pinholes on film surface or suffer from low throughput, respectively. Here, authors vacuum-deposit a 2D capping perovskite layer on solution deposited 3D bulk film, realizing pinhole-free solar submodules with certified efficiency close to 22%.

In this phase 2 trial, YKYY017, a SARS-CoV-2 membrane fusion inhibitor, was tested against mild to moderate COVID-19. Inhaled YKYY017 at 20 mg produced a numerically higher viral load reduction compared with placebo on Day 4, suggesting potential antiviral activity. Both inhaled 10 mg and 20 mg YKYY017 were well-tolerated and had acceptable safety profiles.

This study shows that keto-enol tautomerism in 2,4,6-trihydroxybenzaldehyde (Tp) imine COFs acts as variable electron/hole traps, boosting exciton dissociation and charge transfer. Tp COF (TpBpy) achieves an photocatalytic H₂O₂ generation rate of 8350 μmol h^-1 g^-1 under simulated light, and a solar-to-chemical conversion efficiency of 0.038% in a flow reactor under natural sunlight.

SUMOylation is a post translational modification. Here the authors show that TRPV1, which conveys thermal nociception, is SUMOylated in DRGs in inflammatory conditions and contributes to pain behavior in mice.

This study sheds light on the mechanisms by which different MYB and bHLH transcription factors select their partners to form complexes, and reveals two types of MYB–bHLH interaction modes that are evolutionarily conserved but evolved independently in plants.

Here the authors developed a nucleolus Hi-C technique (nHi-C) for enriching nucleolus-associated interactions, and revealed specific heterochromatin interaction patterns within and around nucleoli in human cells at high resolution.

The performance of ternary organic solar cells is limited by voltage losses. Using the detailed balance principle, Wang et al. show how the third component of the blend affects the open-circuit voltage and delineate molecular design rules.

An acceptor–donor–acceptor organic semiconductor enables near-infrared organic light-emitting diodes with reduced efficiency roll-off over six orders of magnitude of excitation current density, enabling a maximum luminance of 2,000 W sr⁻¹ m⁻².

Combining two global datasets, the authors show that peak vegetation growth has been increasing linearly for the past 30 years, with similar proportions of NDVI variation attributable to expanding croplands, rising CO₂ and intensifying nitrogen deposition.

Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.

A synthesis of global change experiments that manipulated temperature, precipitation, carbon dioxide or nitrogen identifies a need to consider site-specific factors and interactions in Earth system models.

Workers in social insects such as honey bees, bumble bees, and ants are expected to spend their lives helping their mother reproduce. Here the authors show that workers of several bumble bee species can in fact mate and lead colonies of their own.

Satellite records combined with global ecosystem models show a persistent and widespread greening over 25–50% of the global vegetated area; less than 4% of the globe is browning. CO₂ fertilization explains 70% of the observed greening trend.

More than 80% of vegetation burned globally regained its pre-fire level of productivity within 2 years, according to an assessment of post-fire vegetation productivity from 2004 to 2021.

Zuo et al. developed a highly bright and stable green fluorescent RNA for robust imaging of the dynamics of messenger RNA in living cells, enabling visualization of nonuniform and distinct distributions of different RNAs throughout stress granules.

The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.

Organic solar cells based on non-fullerene acceptors have enabled high efficiencies yet their charge dynamics and its impact on the photovoltaic parameters are not fully understood. Now, Chen et al. provide a general description of non-radiative voltage losses in both fullerene and non-fullerene solar cells.

The SARS-COV-2 pandemic has put pressure on intensive care units, so that predicting severe deterioration early is a priority. Here, the authors develop a multimodal severity score including clinical and imaging features that has significantly improved prognostic performance in two validation datasets compared to previous scores.

The climate impact of water-table drawdown in peatlands is unclear as carbon dioxide emissions increase and methane emissions decrease due to drying. This study shows decreasing water-table depth results in net greenhouse gas emissions from global peatlands, despite reducing methane emissions.

Improving the power conversion efficiency is the main target of the organic solar cell research. Here Yuan et al. develop unconventional electron-deficient-core-based non-fullerene acceptors to achieve both low voltage loss and high current density, leading to a certified high efficiency of 12.6%.

How to curb climate change is uncertain, in part because determination of allowable emissions depends on models with low accuracy. Here the authors re-analyze climate-carbon feedbacks and find that CO₂ emissions could be 9 ± 7% higher and still meet Paris Agreement goals.

The biological processes that control the release of carbon stored in land are dependent on water availability. A global analysis of temperature sensitivity reveals how hydrometeorological processes modulate the response of land carbon turnover to temperature.

Greening—increasing leaf area index—affects regional climate in a number of contradictory ways. The net global effect is now revealed to be cooling that has offset the equivalent of 12% of global land-surface warming over the past 30 years.

A recent study suggests that the optimal temperature for symbiotic nitrogen fixation rates exceeds the plant’s preferred growth temperature in laboratory conditions. A few degrees of warming could thereby increase or decrease nitrogen fixation rates, depending on the optimal rate among species.

This protocol for the spatiotemporal control of RNA activity uses LicV, a synthetic, photoswitchable RNA-binding protein (RBP) that can bind to a specific RNA sequence in response to blue light irradiation, and provides an efficient and generalizable strategy for engineering photoswitchable RBPs.