Search

The study presents a single-layer photonic computing (SLiM) chip that mitigates error accumulation by decoupling redundancies. It supports deep learning over 200 layers and enables large language models, advancing efficient photonic hardware for AI.

Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

Follow-up telephone interviews are crucial but labour intensive in large-scale clinical trials. Here, the authors show that a specialized large language model automates this process, outperforming both existing AI systems and human experts in accuracy and efficiency.

Genomic therapy offers a promising strategy for addressing central nervous system disorders. This Review highlights recent advances in chemical strategies and delivery platforms, such as lipid nanoparticles, polymers and oligonucleotide conjugates, and it discusses future directions to improve the application of genomic therapy in brain disorders.

Early detection and accurate diagnosis of focal liver lesions are crucial for effective treatment and prognosis. Here, the authors present a fully automated diagnostic system that leverages multi-phase CT scans and clinical features, for diagnosing liver lesions.

This work presents a portable nanofiber-based imaging technique that uses luminescent nanofibers to achieve high-resolution replication of human skin textures, such as fingerprints, with fine morphological details, including sweat pores, ridges, and scars.

An iontronic tip-sensing guidewire measures haemodynamic and contact pressure in animal stenosis models and can be integrated with commercial workhorse guidewires.

In this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators underlying 31 immune and aging traits, including Parkinson’s disease.

A short-lived carbon release preceded the PETM. Here the global nature of this is confirmed, effects on the surface ocean carbon cycle are resolved, and a thermogenic CO₂ source is inferred.

The authors report on a 2D anion-rich NaCl₂ crystal with a Na:Cl ratio of approximately 1:2, which exhibits room-temperature ferromagnetism originating from the spin polarization of electrons in the Cl elements of these crystals.

Glucocorticoid resistance is partly due to epigenetic alterations, but the regulatory mechanisms driving these remain poorly understood. Here, a link between the activity of a lineage-specific transcription factor PU.1 and epigenetic modulators mediating the response to glucocorticoids is described in acute lymphoblastic leukemia.

Using ¹⁹F nuclear magnetic resonance to study LiF–LiH solid solutions revealed that it is present in the solid–electrolyte interphase of lithium metal batteries and confirms the heterogeneous nature of LiF in such interphases.

SspABCD–SspE is a widespread bacterial defence system against phage infection, in which SspABCD is responsible for introducing phosphorothioate modifications and SspE serves as a nickase that cleaves foreign DNA.

Reducing platinum use is vital for sustainable hydrogen production via proton exchange membrane water electrolysis. Here, the authors report a Mo₂TiC₂ MXene-supported platinum nanocluster catalyst that requires minimal platinum content and operates efficiently for over 8700 h.

Wei, Bai, Wang, and colleagues present HypnoS, a genetically-encoded fluorescent sensor for the real-time monitoring of intracellular adenosine (iAdo) in a cell type-specific manner. They monitor iAdo dynamics during seizures or sleep-wake cycles with high spatiotemporal resolution in the brain of living animals.

High-voltage positive electrodes in sulfide all-solid-state lithium batteries face challenges due to the low oxidation stability of sulfide electrolytes. Here, authors propose a Li₂ZrF₆ coating on LiCoO₂ to suppress interfacial reactions and enhance the long-term battery cycling performance.

Understanding of artificial neural networks function, and their ability to effectively solve specific tasks, still require more rigorous analytical background. Using network science and dynamical systems tools, the authors develop a framework for predicting the performance of artificial neural networks

Developing efficient electrocatalysts for selective CO2 conversion is of high interest. Here the authors investigate B doped Cu single atom catalysts with Cu-N2B2 coordination for enhanced CO2 to CH4 conversion.

Accurate mapping of strain distribution calls for strain sensor arrays with high sensitivity, high sensing density and inter-unit consistency. Here, the authors report an array made from ordered assembly of monodispersed spiky carbon nanospheres to achieve the above features simultaneously.

A bioresorbable, wireless hydrogel (metagel) sensor, encompassing both biodegradable and stimulus-responsive hydrogels for ultrasonic monitoring of intracranial signals, was implanted into intracranial space with a puncture needle and deformed in response to physiological environmental changes.

A method to label membrane proteins with a DNA tag has been developed that enables the selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells. As a demonstration, a 30-million-compound DNA-encoded chemical library is screened against folate receptor, carbonic anhydrase 12 and epidermal growth factor receptor on live cells.

Huang et al. show that, in response to chemotherapy, PTEN directly interacts with NLRP3 in myeloid cells to enhance inflammasome activation and antitumour immune responses.

For electrochemical CO₂ reduction to CO, there exists a trade-off between selectivity and activity for noble metal catalysts. Here, authors report a Cu-based trimetallic catalyst that is selective to CO, challenging the monopoly of noble metals in CO₂-to-CO conversion.

Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.

Ultrasound may be used to non-invasively modulate the brain. Here the authors describe acoustic nanobubble-mediated ultrasound stimulation of specific brain region in male mice.

Currently, the anti-icing performance limitation of superhydrophobic materials is gradually approached without the assistance of an external field. Here, the authors propose a strategy of microdroplet movement manipulation induced by interfacial airflow for further improving the anti-icing performance.

Interpretation of Computed Tomography Angiography for intracranial aneurysm diagnosis can be time-consuming and challenging. Here, the authors present a deep-learning-based framework achieving improved performance compared to that of radiologists and expert neurosurgeons.

Though flexible pressure sensors with high sensitivity are attractive for health monitoring applications, existing device sensing mechanisms limit their practical applicability. Here, the authors report quantum tunnelling-based pressure sensors with high sensitivity and fast signal readout.

mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m⁶A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.

Polymeric nanoparticles can efficiently deliver siRNAs to endothelial cells in vivo and silence multiple genes for weeks.

The receptor LILRB4 on monocytic leukaemia cells suppresses T cell activity and support the infiltration of tumour cells into tissues.

This manuscript describes a methodology to quantify the abnormalities in digital cytology images. This automatic AI-system incorporates deep learning structures, mathematical algorithms, and image processing methods to locate and segment abnormal and suspicious cells. Characterized as more informative, objective, and reproducible, it has the potential to assist clinical practice.