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Showing 1–3 of 3 results
Advanced filters: Author: Yongyue Xu Clear advanced filters

  • Insect genomics is entering a telomere-to-telomere (T2T) era. This study presents a 596-Mb T2T genome of an individual male Bactrocera dorsalis—a species with atypical telomeres, centromeres, and sex-chromosome architecture—advancing genetics, chromosome biology, and pest management.

    • Wei Liu
    • Qiang Lin
    • Guirong Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Skeletal editing has emerged as an appealing strategy for scaffold-hopping-based drug discovery, but the enantioselective single-atom skeletal editing of N-heteroarenes is challenging. Now, using trifluoromethyl N-triftosylhydrazones as carbene precursors, the enantiodivergent dearomative skeletal editing of indoles and pyrroles has been achieved through asymmetric carbon-atom insertion.

    • Xiaolong Zhang
    • Qingmin Song
    • Xihe Bi
    Research
    Nature Chemistry
    Volume: 17, P: 215-225

  • RNAs and their encoded proteins intricately regulate diverse cell types and states within the human body. Here the authors report an RNA-IN/OUT genetic circuit to sense and respond any endogenous RNA with single-nucleotide resolution allowing them to dynamically monitor stem cell differentiations, and rewire regulatory networks in mammals.

    • Min Zhang
    • Xue Zhang
    • Chunbo Lou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11