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Showing 1–50 of 71 results

Advanced filters: Author: Yu Yokoyama Clear advanced filters

LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC

Existing inhibitors for lysine-specific histone demethylase 1A (LSD1), a key driver for small cell lung cancer (SCLC) carcinogenesis, have notable limitations. Here, the authors employ structure-based engineering to develop a histone H3-competitive LSD1 inhibitor to enhance specificity and reduce off-target effects in SCLC cells through transcriptional regulation and epigenetic reprogramming.

Takumitsu Machida
Yingbo Gong
Tomoaki Tanaka
ResearchOpen Access25 Mar 2026
Nature Communications

P: 1-24
Autoantibodies against nephrin and podocin are associated with disease severity and steroid dependence in adult-onset nephrotic syndrome

Norifumi Hayashi
Ryoko Akai
Kengo Furuichi
ResearchOpen Access16 Mar 2026
Scientific Reports

P: 1-8
ARMH2 is a cytosolic component of CatSper crucial for sperm function

ARMH2 is identified as a previously unknown cytosolic component of the sperm-specific CatSper channel, critical for its normal assembly and pH/calcium sensitivity. Loss of ARMH2 impairs sperm hyperactivation and causes severe subfertility.

Qingqing Zhao
Shiyi Lin
Jianping Wu
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-15
NSUN7 is a catalytically inactive RNA m⁵C methyltransferase essential for sperm flagellum assembly

The NSUN family, comprising seven members, is the primary RNA m5C methyltransferase in higher eukaryotes. Here, the authors demonstrate that NSUN7 is a catalytically inactive RNA m5C protein due to sequence variations in its motif IV. Instead, the authors reveal a noncatalytic, regulatory role of NSUN7 in sperm flagellum assembly.

Jing Li
Wen-Yu Zhu
Ru-Juan Liu
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2

Jianzhi Pan
Koji Nakade
Kazunari Yokoyama
ResearchOpen Access08 Oct 2009
Nature Precedings

P: 1
Accurate prediction of hypoglycemia and hyperglycemia using machine learning in critically ill patients

Yu Ikeda
Satoru Sugimoto
Taka-aki Nakada
ResearchOpen Access18 Dec 2025
Scientific Reports

Volume: 16, P: 1-9
Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges

Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic potential of ‘Entotheonella’ symbionts, a talented producer taxon from microbial dark matter.

Maria Dell
Masato Kogawa
Jörn Piel
ResearchOpen Access13 Nov 2025
Nature Chemical Biology

Volume: 22, P: 217-228
Origin of Symmetric Dimer Images of Si(001) Observed by Low-Temperature Scanning Tunneling Microscopy

Xiao-Yan Ren
Hyun-Jung Kim
Jun-Hyung Cho
ResearchOpen Access13 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Priming of naive T cells inside tumors leads to eradication of established tumors

Ping Yu
Youjin Lee
Yang-Xin Fu
Research04 Jan 2004
Nature Immunology

Volume: 5, P: 141-149
Joint neutrino oscillation analysis from the T2K and NOvA experiments

The joint analysis of datasets from NOvA and T2K, the two currently operating long-baseline neutrino oscillation experiments, provides new constraints related to neutrino masses and fundamental symmetries.

S. Abubakar
M. A. Acero
S. Zsoldos
ResearchOpen Access22 Oct 2025
Nature

Volume: 646, P: 818-824
Sustained North Atlantic warming drove anomalously intense MIS 11c interglacial

Radiometrically dated speleothems are used to constrain the timing and duration of Marine Isotope Stage 11c. Early low-to-middle latitude warming in the North Atlantic led to an exceptionally developed interglacial despite weak insolation forcing.

Hsun-Ming Hu
Gianluca Marino
Chuan-Chou Shen
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-11
A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

Neurodegenerative diseases are linked to changes in the immune system and inflammation. Here, the authors studied immune cells from healthy individuals and neurodegenerative diseases and identified sex-specific disease-associated changes.

Friederike Grandke
Tobias Fehlmann
Andreas Keller
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC

DeNardo and colleagues show that tissue-resident macrophages (TRMs) have a protective role during pancreas inflammation by triggering the activation of fibroblasts, but that TRM-driven fibrosis drives pancreas cancer pathogenesis.

John M. Baer
Chong Zuo
David G. DeNardo
Research10 Aug 2023
Nature Immunology

Volume: 24, P: 1443-1457
Near-synchronous Northern Hemisphere and Patagonian Ice Sheet variation over the last glacial cycle

Patagonian ice sheet changes largely mirrored those of the Northern Hemisphere over the last glacial cycle owing to displacements of the southern westerly winds, according to beryllium isotope constraints.

Adam D. Sproson
Yusuke Yokoyama
Siyao M. Yu
Research08 May 2024
Nature Geoscience

Volume: 17, P: 450-457
Complex Formation of Silk Fibroin with Poly(acrylic acid)

Qinwei Gao
Zhengzhong Shao
Tongyin Yu
Research01 Mar 2000
Polymer Journal

Volume: 32, P: 269-274
Regular-triangle trimer and charge order preserving the Anderson condition in the pyrochlore structure of CsW₂O₆

Many rules have been suggested to rationalize the behaviour of transition metal oxides but the complex underlying physics often leads to deviations from the expected behaviour. Here the authors show that the metal-insulator transition in CsW₂O₆ satisfies the Anderson condition in an unusual way.

Yoshihiko Okamoto
Haruki Amano
Koshi Takenaka
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-8
A chemical toolkit for proteins — an expanded genetic code

Recently, a method was developed to encode unnatural amino acids genetically in bacteria, yeast and mammalian cells. This provides a powerful tool for exploring protein structure and functionin vitro and in vivo, and for generating proteins with new or enhanced properties.

Jianming Xie
Peter G. Schultz
Reviews23 Aug 2006
Nature Reviews Molecular Cell Biology

Volume: 7, P: 775-782
Association of Dog and Cat Ownership with Incident Frailty among Community-Dwelling Elderly Japanese

Yu Taniguchi
Satoshi Seino
Shoji Shinkai
ResearchOpen Access09 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
Direct evidence of electronic ferroelectricity in YbFe₂O₄ using neutron diffraction and nonlinear spectroscopy

K. Fujiwara
Y. Fukada
Y. Okimoto
ResearchOpen Access19 Feb 2021
Scientific Reports

Volume: 11, P: 1-7
Discovery of earth-abundant nitride semiconductors by computational screening and high-pressure synthesis

Nitride semiconductors are attractive for various applications. Here a computational screening study identifies a number of possible ternary nitrides as promising candidates, including a phase that the authors synthesize for the first time via a high-pressure route.

Yoyo Hinuma
Taisuke Hatakeyama
Fumiyasu Oba
ResearchOpen Access21 Jun 2016
Nature Communications

Volume: 7, P: 1-10
Norepinephrine links astrocytic activity to regulation of cortical state

The authors show that norepinephrine signaling to astrocytes in the mouse visual cortex acts as a separate neuromodulatory pathway that regulates the effects of arousal on neuronal activity and cortical state.

Michael E. Reitman
Vincent Tse
Kira E. Poskanzer
ResearchOpen Access30 Mar 2023
Nature Neuroscience

Volume: 26, P: 579-593
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription

Yufeng Wei
Shaohua Liu
Milton H Werner
Research17 Jun 2007
Nature Structural & Molecular Biology

Volume: 14, P: 653-661
Traceless aptamer-mediated isolation of CD8⁺ T cells for chimeric antigen receptor T-cell therapy

DNA aptamers that specifically bind to the T-cell marker CD8 and can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8⁺ T cells for chimeric antigen receptor T-cell therapies.

Nataly Kacherovsky
Ian I. Cardle
Suzie H. Pun
Research17 Jun 2019
Nature Biomedical Engineering

Volume: 3, P: 783-795
Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy

Gentao Liu
Yasuharu Akasaki
John S Yu
Research16 May 2005
Oncogene

Volume: 24, P: 5226-5234
Specific Interactions in Silk Fibroin–Poly(potassium acrylate) Blends

Zhengzhong Shao
Yuyu Sun
Tongyin Yu
Research01 May 1999
Polymer Journal

Volume: 31, P: 470-475
Association of nighttime very short-term blood pressure variability determined by pulse transit time with adverse prognosis in patients with heart failure

Yu Sato
Akiomi Yoshihisa
Yasuchika Takeishi
Research20 Jan 2025
Hypertension Research

Volume: 48, P: 1305-1314
Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer

M P A Ebert
J Yu
P Malfertheiner
ResearchOpen Access04 May 2000
British Journal of Cancer

Volume: 82, P: 1795-1800
Constraint on the matter–antimatter symmetry-violating phase in neutrino oscillations

The T2K experiment constrains CP symmetry in neutrino oscillations, excluding 46% of possible values of the CP violating parameter at a significance of three standard deviations; this is an important milestone to test CP symmetry conservation in leptons and whether the Universe’s matter–antimatter imbalance originates from leptons.

K. Abe
R. Akutsu
A. Zykova
Research15 Apr 2020
Nature

Volume: 580, P: 339-344
Biosynthesis of 3′-Deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius Mutant Strain by tacB Gene Disruption

Yonghong Yu
Xifan Hou
Huanzhang Xia
Research01 Feb 2008
The Journal of Antibiotics

Volume: 61, P: 63-69
Author Correction: High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer’s Disease Study

Yara Alkhodair
Ging-Yuek R. Hsiung
Eugene Yau
Amendments and CorrectionsOpen Access21 Nov 2025
npj Dementia

Volume: 1, P: 1
Therapeutic targeting of the functionally elusive TAM receptor family

The TAM tyrosine kinase receptors TYRO3, AXL and MERTK regulate tissue and immune homeostasis. This Review discusses how their aberrant signalling is linked to diseases such as cancer, fibrosis and viral infection, and surveys the therapeutic landscape of TAM receptor inhibitors in preclinical and clinical development.

Yu Rebecca Miao
Erinn B. Rankin
Amato J. Giaccia
Reviews13 Dec 2023
Nature Reviews Drug Discovery

Volume: 23, P: 201-217
Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

An event-based machine learning model developed to detect fluorescent astrocytic activity and neurotransmitter dynamics enables new and accurate approaches to quantifying physiology in brain slices and in vivo.

Yizhi Wang
Nicole V. DelRosso
Kira E. Poskanzer
Research30 Sept 2019
Nature Neuroscience

Volume: 22, P: 1936-1944
The cDNA cloning of the transcripts of human PEBP2αA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia

Yu-Wen Zhang
Suk-Chul Bae
Yoshiaki Ito
Research17 Jul 1997
Oncogene

Volume: 15, P: 367-371
The effects of lipid-lowering therapy on coronary plaque regression: a systematic review and meta-analysis

Yingrui Li
Songbai Deng
Qiang She
ResearchOpen Access12 Apr 2021
Scientific Reports

Volume: 11, P: 1-10
High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis

Dawei Zhu
Xing Gu
Jing Wang
ResearchOpen Access20 May 2021
Oncogenesis

Volume: 10, P: 1-12
Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells

Hao-yu Yuan
Shuang-yu Kuang
Duan-Fang Liao
Research01 May 2008
Acta Pharmacologica Sinica

Volume: 29, P: 555-563
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Receptor subtype involved in α₁-adrenergic receptor-mediated Ca²⁺ signaling in cardiomyocytes

Da-li Luo
Jian Gao
Qi-de Han
Research01 Jul 2007
Acta Pharmacologica Sinica

Volume: 28, P: 968-974
High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer’s Disease Study

Yara Alkhodair
Ging-Yuek R. Hsiung
Eugene Yau
ResearchOpen Access30 Jul 2025
npj Dementia

Volume: 1, P: 1-7
Leukemia, an effective model for chemical biology and target therapy

Guo-qiang Chen
Li-shun Wang
Yun Yu
Reviews01 Sept 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1316-1324
Novel genomic alteration in superficial esophageal squamous cell neoplasms in non-smoker non-drinker females

Yusuke Onozato
Yu Sasaki
Yoshiyuki Ueno
ResearchOpen Access11 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Structural degradation of tungsten sandwiched in hafnia layers determined by in-situ XRD up to 1520 °C

Gnanavel Vaidhyanathan Krishnamurthy
Manohar Chirumamilla
Michael Störmer
ResearchOpen Access08 Feb 2021
Scientific Reports

Volume: 11, P: 1-12
Whole-genome sequencing of myeloproliferative neoplasms revealed dynamic clonal changes in the fibrotic or leukemic transformation and novel FOXP1 mutations in the fibrotic transformation

Hiroyuki Takamori
Ying-Jung Huang
Lee-Yung Shih
Research31 Mar 2025
Leukemia

Volume: 39, P: 1218-1227
The performance of optic disc-macula distance to disc-diameter ratio in qualitative and quantitative assessment of the optic disc size

Akira Ishikawa
Kazumi Kusaka
Yu Yokoyama
Research06 Dec 2024
Eye

Volume: 39, P: 969-976
Trans-differentiation of Jdp2-depleted Gaba-receptor-positive cerebellar granule cells to Purkinje cells

Chia-Chen Ku
Jia-Bin Pan
Kazunari K. Yokoyama
ResearchOpen Access18 Dec 2024
Cell Death Discovery

Volume: 10, P: 1-12
Relationship between corneal hysteresis and the site of damage to peripapillary retinal nerve fibre layer thickness in open-angle glaucoma

Yoko Takeda
Akiko Hanyuda
Toru Nakazawa
ResearchOpen Access01 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma

Kota Sato
Daisuke Saigusa
Toru Nakazawa
ResearchOpen Access21 Nov 2023
npj Aging

Volume: 9, P: 1-10
Birth order and prosociality in the early adolescent brain

Naohiro Okada
Yu Yamamoto
Kiyoto Kasai
ResearchOpen Access08 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers

C-H Chen
Y-L Chiu
K-J Hsiao
Research16 Nov 1999
Molecular Psychiatry

Volume: 4, P: 566-571
Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors

Yu Chen
Tatsuki Yamamoto
Rieko Ohki
ResearchOpen Access07 Sept 2023
Cell Death & Disease

Volume: 14, P: 1-13

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