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Showing 1–50 of 51 results

Advanced filters: Author: Yuanli Liu Clear advanced filters

Organoid Modeling and Single-Cell Profiling Reveal Smooth Muscle Cell Migration in Moyamoya Disease

Organoid modeling and single-cell profiling reveal TUBA4A and TUBB4B tubilin proteins-driven vascular smooth muscle cell migration and contractile-to-synthetic phenotypic switching via GJA1/PI3K/AKT/KLF4 pathway in Moyamoya disease.

Shihao He
Junze Zhang
Rong Wang
ResearchOpen Access07 Jan 2026
Communications Biology

P: 1-16
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Adapting health, economic and social policies to address population aging in China

China’s dramatic demographic shift toward population aging raises challenges at the individual, familial and societal levels. Fang et al. review these challenges and emerging policies designed to promote healthy longevity in China.

Evandro F. Fang
Yuan Fang
Huachun Zou
Reviews31 Oct 2025
Nature Aging

Volume: 5, P: 2176-2187
Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes

Incorporation of deuterium into small molecules in the place of hydrogens can alter the properties of the molecule in ways that provide benefits without affecting the core function of the molecule. Here, the authors report a ring-opening deuteration of cyclic alkanes via biphosphonium photocatalysis.

Yuanli Xu
Wenlong Chen
Zhiwei Zuo
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-9
MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis

Qian and colleagues show that MEF2D⁺ cancer precursors reprogram liver-resident Kupffer cells to create a microenvironment supporting liver tumorigenesis.

Junyu Xiang
Yuanli Ni
Cheng Qian
Research23 Oct 2025
Nature Cancer

Volume: 6, P: 1955-1975
Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses

Gefei Wang
Juan Zhang
Kangsheng Li
Research01 Apr 2008
Cellular & Molecular Immunology

Volume: 5, P: 113-120
Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity

Excessive production of reactive oxygen species (ROS) in cancer cells can induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that intermetallics modified with glucose oxidase and soybean phospholipid as nano-inducers promote cancer cell pyroptosis and disulfidptosis, resulting in ICD and anti-tumor immunity in preclinical models.

Yanlin Zhu
Xinxin Wang
Piaoping Yang
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-21
Identification of molecular characteristics in polycystic ovary syndrome using single-cell and transcriptome analysis

Xiaolin Zhu
Yanhua Han
Yaguang Han
ResearchOpen Access23 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Regulating the scaling relationship for high catalytic kinetics and selectivity of the oxygen reduction reaction

Improving kinetics for electrochemical oxygen reduction reaction is relevant to important sustainable energy technologies. The authors propose an atomic-scale bimetal assembly consisting Pt and Fe dual sites to regulate the inherent scaling relationship between intermediates for fast kinetics.

Wanlin Zhou
Hui Su
Qinghua Liu
ResearchOpen Access27 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Association analysis identifies new risk loci for congenital heart disease in Chinese populations

Genome-wide association studies in Chinese and Europeans have identified multiple loci associated with congenital heart disease. Here the authors use existing GWAS data to conduct an extended three-stage analysis in Han Chinese and identify four novel loci linked to disease risk in this population.

Yuan Lin
Xuejiang Guo
Zhibin Hu
Research18 Aug 2015
Nature Communications

Volume: 6, P: 1-7
Programmable trans-splicing riboregulators for complex cellular logic computation

Scaling up genetic circuits is a longstanding challenge in synthetic biology. Here Gao et al. engineer split introns for programmable RNA-level gene regulation and integrate them with protein splicing for single-layer multi-input logic computation.

Yuanli Gao
Rizki Mardian
Baojun Wang
Research02 Jan 2025
Nature Chemical Biology

Volume: 21, P: 758-766
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma

FGFR inhibitors (FGFRi) benefit patients with FGFR2-fusion positive intrahepatic cholangiocarcinoma (ICC) but depth and duration of response is often limited. Here, the authors demonstrate that oncogenic FGFR2 signaling promotes a glycolytic phenotype, which is blocked by FGFRi, resulting in a targetable dependence on mitochondrial metabolism.

Yuanli Zhen
Kai Liu
Nabeel Bardeesy
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-17
In-situ spectroscopic observation of dynamic-coupling oxygen on atomically dispersed iridium electrocatalyst for acidic water oxidation

Uncovering the dynamics of active sites in the working conditions is important yet challenging. Here the authors identify dynamic-coupling oxygen on atomically dispersed iridium sites during oxygen evolution reaction using in situ techniques.

Hui Su
Wanlin Zhou
Shiqiang Wei
ResearchOpen Access21 Oct 2021
Nature Communications

Volume: 12, P: 1-9
Multi-strategy collaborative optimization of gravitational search algorithm

Zhonghua Yang
Yuanli Cai
Yu Chen
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-29
Harnessing alternative splicing for off-the-shelf mRNA neoantigen vaccines in hepatocellular carcinoma

Haichao Zhao
Yifei Cheng
Qiang Gao
Research28 Nov 2025
Cell Research

Volume: 35, P: 970-986
Association between DIAPH1 variant and posterior circulation involvement with Moyamoya disease

Shihao He
Xiaokuan Hao
Yuanli Zhao
ResearchOpen Access03 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
Reconstruction of Indigenous settlements in ecologically fragile areas through spatial distribution patterns and suitability in Xiaoliangshan, SW China

Yi-Won Addi
Mengran Li
Heping Liao
ResearchOpen Access24 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Evaluation of regulatory genetic variants in POU5F1 and risk of congenital heart disease in Han Chinese

Yuan Lin
Chenyue Ding
Zhibin Hu
ResearchOpen Access28 Oct 2015
Scientific Reports

Volume: 5, P: 1-7
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus

The sperm head-to-tail coupling apparatus ensures sperm head-tail integrity, but mechanistic insights remain limited. Here the authors demonstrate that CENTLEIN links and controls the interaction between SUN5 and PMFBP1, indicating that its impairments might be associated with acephalic spermatozoa syndrome.

Ying Zhang
Chao Liu
Li Yuan
ResearchOpen Access13 Aug 2021
Nature Communications

Volume: 12, P: 1-16
Corncob cellulose nanosphere as an eco-friendly detergent

Synthetic detergents are environmentally damaging and eco-friendly alternatives would help reduce environmental impacts. This study shows a more sustainable detergent, based on cellulose nanospheres obtained from agricultural waste corncob, with strong cleaning performance and low toxicity.

Bin Liu
Tao Li
Yuan Li
Research23 Mar 2020
Nature Sustainability

Volume: 3, P: 448-458
Spleen volume in relation to ulcerative colitis and Crohn’s disease: a Mendelian randomization study

Qiang Su
Jian Li
Zhizhong Zhang
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency

Fang E.
He Zhang
Xu Gao
ResearchOpen Access20 Dec 2021
Cell Death & Disease

Volume: 13, P: 1-9
Evolutionary game analysis of healthcare data governance in China’s experimental data trading pilots

Han Yao
Yuanli Liu
ResearchOpen Access01 Sept 2025
npj Digital Medicine

Volume: 8, P: 1-17
Integrating gonadal RNA-seq and small RNA-seq to analyze mRNA and miRNA changes in medaka sex differentiation

Xing Lin
Yuanli Zhao
Daji Luo
ResearchOpen Access12 May 2025
Scientific Data

Volume: 12, P: 1-11
Association between maternal exposure to ambient air pollutants during pregnancy and fetal growth restriction

Shiliang Liu
Daniel Krewski
Richard T Burnett
Research31 May 2006
Journal of Exposure Science & Environmental Epidemiology

Volume: 17, P: 426-432
IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD

Chenying Han
Chenchen Hu
Shuya Yang
ResearchOpen Access14 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-11
Machine learning identifies KRT8 dysregulation and endothelial remodeling in Moyamoya disease

Zhiguang Han
Jialong Yuan
Shihao He
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis

Hui Liu
Yuanli Zhu
Jun Xiao
ResearchOpen Access18 Feb 2020
Cell Death & Disease

Volume: 11, P: 1-18
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway

Shufeng Xie
Hui Liu
Han Liu
ResearchOpen Access09 Aug 2024
Cancer Gene Therapy

Volume: 31, P: 1486-1497
Urban travel carbon emission mitigation approach using deep reinforcement learning

Jie Shen
Fanghao Zheng
Zhiang Zhang
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-21
Integrating Iso-seq and RNA-seq data for the reannotation of the greater amberjack genome

Yuanli Zhao
Zonggui Chen
Daji Luo
ResearchOpen Access22 Jun 2024
Scientific Data

Volume: 11, P: 1-10
Longitudinal association of carotid endothelial shear stress with renal function decline in aging adults with normal renal function: A population-based cohort study

Yingxin Zhao
Yuanli Dong
Zhendong Liu
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Downregulation of miR-181c-5p in Alzheimer’s disease weakens the response of microglia to Aβ phagocytosis

Rongjie Li
Shanshan Yao
Ying Liu
ResearchOpen Access20 May 2024
Scientific Reports

Volume: 14, P: 1-11
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy

Mengyang Liu
Quan Pan
Yajun Duan
ResearchOpen Access10 Jun 2015
Scientific Reports

Volume: 5, P: 1-14
Enhanced thermal conductivity of epoxy composites filled with silicon carbide nanowires

Dianyu Shen
Zhaolin Zhan
Jinhong Yu
ResearchOpen Access01 Jun 2017
Scientific Reports

Volume: 7, P: 1-11
B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4⁺T cell cytotoxicity through ESM1

Jiatao Li
Juan Feng
Cheng Qian
ResearchOpen Access01 Jul 2024
npj Precision Oncology

Volume: 8, P: 1-16
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice

Shu Yang
Mengyang Liu
Xiaoxiao Yang
ResearchOpen Access14 Jun 2018
Scientific Reports

Volume: 8, P: 1-14
Bridging the incompatibility gap in dual asymmetric catalysis over a thermoresponsive hydrogel-supported catalyst

Dual asymmetric catalysis is powerful for the synthesis of multi-stereocenter molecules, however, the integration of dual catalysts remains challenging due to the intrinsic deactivation of dual-species and extrinsic conflict of reaction conditions. Here, the authors develop a compartmental and thermoresponsive poly(N-isopropylacrylamide)-hydrogel-supported bifunctional catalyst to overcome these challenges.

Renfu Huang
Shoujin Yang
Guohua Liu
ResearchOpen Access03 Jan 2024
Communications Chemistry

Volume: 7, P: 1-12
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway

Shufeng Xie
Hui Liu
Han Liu
Amendments and CorrectionsOpen Access21 Oct 2024
Cancer Gene Therapy

Volume: 31, P: 1750
CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells

Yu Liang
Hao Han
Yuanli Chen
ResearchOpen Access21 Dec 2018
Oncogenesis

Volume: 7, P: 1-14
Decision-making psychological state and characteristic of proxies of thrombolytic patients: a pilot study

Guo Yuanli
Liu Yanjin
Ma Keke
ResearchOpen Access20 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia

Ruiheng Wang
Shufeng Xie
Han Liu
ResearchOpen Access08 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-10
Effects of sartans and low-dose statins on cerebral white matter hyperintensities and cognitive function in older patients with hypertension: a randomized, double-blind and placebo-controlled clinical trial

Hua Zhang
Yi Cui
Zhendong Liu
Research14 Dec 2018
Hypertension Research

Volume: 42, P: 717-729
Passive smoking and stroke in men and women: a national population-based case-control study in China

Lei Hou
Wei Han
Junyao Li
ResearchOpen Access31 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice

Qixue Wang
Lei Sun
Yajun Duan
ResearchOpen Access02 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Alterations of the gut microbiome of largemouth bronze gudgeon (Coreius guichenoti) suffering from furunculosis

Tongtong Li
Meng Long
Aihua Li
ResearchOpen Access28 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis

Wenli Li
Xiaolan Tian
Guochun Wang
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy

Yanyan Zhao
Junfang Wei
Liang Feng
ResearchOpen Access31 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly

Dandan Duan
Yuanli Dong
Zhendong Liu
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Dynamic heterogeneity in complex interfaces of soft interface-dominated materials

Leonard M. C. Sagis
Bingxue Liu
Karin Schroen
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-12

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