Nature Search

RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer

Bone and blood lineage cells communicate each other to maintain skeletal homeostasis. Here authors show that osteolineage RIPK4 couples osteogenesis and myelopoiesis via MFN2 to regulate mitochondrial dynamics.

Peng Ding
Xing Wang
Changqing Zhang
ResearchOpen Access19 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Concentrated-solar catalytic methane dry reforming with ultrahigh conversion and durability

Dry reforming of methane (DRM) supports the circular economy and energy sustainability, yet its application is limited by high operating temperatures and coke formation. Here, the authors introduce a concentrated-solar catalytic DRM strategy that overcomes these challenges.

Zhiqiang Rao
Zeai Huang
Ying Zhou
ResearchOpen Access30 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Global analysis of protein structural changes in complex proteomes

Coupling limited proteolysis and a proteomics workflow enables measurement of both subtle and wholesale protein conformational changes in a eukaryotic proteome.

Yuehan Feng
Giorgia De Franceschi
Paola Picotti
Research14 Sept 2014
Nature Biotechnology

Volume: 32, P: 1036-1044
Unveiling proteomic and peptide-level modifications in cerebrospinal fluid and plasma in normal cognitive aging

Kamalian et al. presents a deep proteomic and peptide-level analysis of matched cerebrospinal fluid and plasma from cognitively normal adults (From 18- to 83-year-olds). This study reveals distinct molecular signatures of normal aging and uncovers age-associated cleavage and phosphorylation events in key proteins such as APP, APOE, and NRXN1.

Aida Kamalian
Polina Shichkova
Abhay Moghekar
ResearchOpen Access18 Nov 2025
Communications Medicine

Volume: 5, P: 1-13
Identification of breast cancer patients based on human signaling network motifs

Lina Chen
Xiaoli Qu
Yuehan He
ResearchOpen Access28 Nov 2013
Scientific Reports

Volume: 3, P: 1-7
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Several neurodegenerative diseases are characterized by the aggregation of cytoplasmic proteins. Here, the authors demonstrate that the small molecule SMER28 activates VCP, which enhances both autophagic and proteasomal clearance of aggregate-prone proteins.

Lidia Wrobel
Sandra M. Hill
David C. Rubinsztein
ResearchOpen Access16 Jul 2022
Nature Communications

Volume: 13, P: 1-19
Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry

Many intra- and extracellular signals induce structural changes in proteins. Schopper et al., describe a limited proteolysis–based mass spectrometry (LiP-MS) approach to characterizing these changes at a proteome-wide scale.

Simone Schopper
Abdullah Kahraman
Paola Picotti
Protocols26 Oct 2017
Nature Protocols

Volume: 12, P: 2391-2410
Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

Saad et al. identify stress-induced reversible protein aggregation as a protective mechanism to ensure cell cycle resumption and cell survival after stress in yeast.

Shady Saad
Gea Cereghetti
Reinhard Dechant
Research28 Aug 2017
Nature Cell Biology

Volume: 19, P: 1202-1213
Elovanoid-N34 modulates TXNRD1 key in protection against oxidative stress-related diseases

Jorgelina M. Calandria
Surjyadipta Bhattacharjee
Nicolas G. Bazan
ResearchOpen Access13 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-10
Development of a prognostic model for anoikis and identifies hub genes in hepatocellular carcinoma

Zhiwei Zhong
Fuchun Xie
Bo Tang
ResearchOpen Access07 Sept 2023
Scientific Reports

Volume: 13, P: 1-19

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