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Tumor-associated macrophages play central roles in the cellular immune response in the tumor microenvironment. Here the authors implicate the m6A methyltransferase METTL3 in glioma progression by regulation of the ISG15/FASN modulated lipid metabolism in macrophage.

Hirschsprung disease, characterized by the absence of ganglion cells leading to functional bowel obstruction, can be treated with surgery. Here, the authors report that preoperative nutritional support in children with Hirschsprung disease reduced the risk of postoperative enterocolitis by comparison to standard of care in a randomized controlled trial.

Shape-changing materials have potential in a range of applications, but these transformations can be challenging to control. Here, the authors report the hydrophobic pseudo-hydrogel, which utilizes absorption-induced expansion via elastocapillarity to enable versatile soft robotic applications.

Linear scaling relationships often hinder the optimization of heterogeneous catalysts. Now, an intermediate spillover strategy is put forward by designing bi-component catalysts, thereby decoupling elementary electron-transfer steps and circumventing linear scaling relationships.

Twisted van der Waals structures represent a versatile platform to investigate topological and correlated electronic states. Here, the authors report the visualization of an electron crystal phase in twisted monolayer-bilayer graphene via scanning tunnelling microscopy, studying the coupling between strong electron correlation and nontrivial band topology.

To improve the tolerance of perovskite solar cells against high temperatures and temperature variations, Dong et al. covalently cross-link two molecules in the charge transport layer to strengthen adhesion with the perovskite layer.

The introduction of ethylenediammonium diiodide reduces defects but also leads to severe hysteresis caused by excessive mobilized ions. Here, authors employ hydrazine monohydrochloride as a bulk passivator to mitigate such hysteresis, achieving maximum efficiency of 28.55% for tandem solar cells.

The introduction of sodium heparin passivates interface defects and enhances bonding between the electron transport layer and the perovskite layer in perovskite solar cells. The best-performing devices exhibit a certified PCE of 26.54% and maintain almost 95% of their initial performance after 1,800 h of maximum power point tracking.

Single-atom catalysts for sodium-sulfur batteries typically use d-block transition metal centers to accelerate polysulfide conversion, while s-block metals are generally considered inactive. Here, authors design a calcium-based single-atom catalyst for sodium-sulfur batteries.

The authors report a modulation of the magnon spin current by electric polarization reversal.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Solar-driven carbon dioxide reduction has witnessed a renaissance in the past decades, but the system suffers from low reaction rates. Here the authors develop a copper/tin-oxide electrocatalyst, achieving a new benchmark solar-to-CO energy conversion efficiency in a flow electrolyzer.

Acidic CO₂ electroreduction suffers poor selectivity for multi-carbon products. Here, the authors report that lengthening the 2-position substituents of benzimidazole-based copper coordination polymer precatalysts retards H⁺ diffusion, reduces Cu-Cu coordination numbers, and promotes C-C coupling.

Mixed-dimensional 1D-2D heterostructures hold promise for catalytic and optoelectronic applications, but the control of their electronic band structure remains challenging. Here, the authors report the fabrication of 1D-graphene nanoribbon/2D-CuSe heterojunctions with tunable band alignment by varying the geometry and phase of the materials.

Glioblastoma (GBM) treatment faces challenges due to drug resistance. Here, the authors show that lysine-arginine balance supports lysosomes mediated tolerance to temozolomide and lysine restriction mimetic increases anticancer therapies in GBM preclinical models.

The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared to iron-normal controls.

Polymer solar cells promise a cost-effective way to harness solar energy, but cell performance is held back by limited choices of suitable materials. Here, Liu et al.demonstrate record cell efficiencies for multiple material combinations via a new approach of aggregation and morphology control.

An analysis of subsoil structure using lunar regolith penetrating radar at the Chang’E-6 landing site indicates a distinct 2-layer structure, and when compared with Apollo mission data, suggests a link between regolith maturity and electromagnetic properties.

Complex-valued neural networks can recognize phase-sensitive data in wave-related phenomena. Here, authors report a complex-valued optical convolution accelerator operating at over 2 TOPS for recognition of radar images, represents advances towards real-time analysis of complex satellite data.

Most piezoelectric coefficients in piezoelectric ceramics are zero, resulting in many piezoelectric vibration modes cannot be excited. Here, the authors propose an orderly stacked structure to achieve all nonzero piezoelectric coefficients.

ZrCo, a promising hydrogen isotope storage material, has poor cyclic storage capacity. Here author reveal a defect-derived disproportionation mechanism and report a nano-single-crystal strategy to comprehensively improve performances.

Accurate delineation of individual teeth and alveolar bones from dental cone-beam CT images is an essential step in digital dentistry for precision dental healthcare. Here, the authors present a deep learning system for efficient, precise, and fully automatic segmentation of real-patient CBCT images presenting highly variable appearances.

Designing synthetic surfaces whose properties dynamically adapt in response to mechanical stimuli is challenging. Now, liquid-infused nanoporous elastic substrates that respond to stretching by continuously changing their transparency and wettability—a consequence of smooth variations in surface roughening as the liquid flows inside the pores—are demonstrated.

Dynamic cell walls enable stomata rapidly responding to the environment. Here the authors report that a maize epimerase is involved in cell wall polysaccharide biosynthesis and glycosylation modulation during stomatal morphogenesis.

It is difficult to control the geometric phase of particles as they undergo quantum tunnelling. Now tuning of the geometric phase of electron spin is demonstrated in tunnelling in a multilayer van der Waals antiferromagnet.

Soft multilayer electronic arrays on endocardial balloon catheters allow for multiplexed high-density spatiotemporal sensing and actuation, as shown in perfused ex vivo hearts.

Here, authors report a macroscopical grain boundary-free interface layer with microscopic Li + -selective conductive channels enables the ultra-dense Li metal deposition, resulting in a high energy density (506 Wh kg⁻¹) and long cycle life (160 cycles) pouch cell performance.

An air purification strategy is presented that moves air in the form of bubbles through an ion-doped conjugated polymer-coated matrix, which captures larger particulate matter, infiltrated with a selected functional liquid, which captures smaller particulate matter.

The authors present detailed procedures to fabricate, encapsulate and implant advanced wireless battery-free devices in head- and back-mounted forms in order to facilitate optogenetic experiments in freely moving rodents.

Long Chen and colleagues show a fully autonomous open-pit mine. Heterogenous machinery and tasks are coordinated using parallel learning and digital twins.