Nature Search

Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas

Ovarian endometriomas, with distinct microenvironment and heightened hormonal sensitivity, are recognized as precursors of ovarian carcinomas. This study decodes ovarian endometriomas by integrating single-cell and spatial transcriptomics with spatial metabolomics to reveal key markers and altered pathways, offering new avenues for diagnosis and therapy.

Yujuan Qi
Xia Chen
Jun Yu
ResearchOpen Access22 Nov 2025
Nature Communications

Volume: 16, P: 1-17
Author Correction: Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Min Li
Xuxiao He
Huiyong Yin
Amendments and Corrections04 Nov 2025
Nature Cancer

Volume: 6, P: 1900
Pathways from early-life urbanicity to adult neurobehavioral traits via menarche timing

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Lining Guo
Feng Liu
Yue Wu
Research15 Dec 2025
Nature Cities

Volume: 2, P: 1226-1239
The genetic architecture of brainstem structures

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Hui Xue
Jilian Fu
Yue Wu
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-18
AmotL2 disrupts apical–basal cell polarity and promotes tumour invasion

Loss of cell polarity is frequently observed in metastatic tumours. Mojallal et al.show that this loss is associated with expression of the scaffold protein AmotL2 in human tumours, and reveal that AmotL2 disrupts the transport of polarity complexes to the plasma membrane following its induction by hypoxia.

Mahdi Mojallal
Yujuan Zheng
Lars Holmgren
Research01 Aug 2014
Nature Communications

Volume: 5, P: 1-14
EBV-Induced Human CD8⁺ NKT Cells Synergise CD4⁺ NKT Cells Suppressing EBV-Associated Tumours Upon Induction of Th1-Bias

Wei Xiao
Li Li
Yuling He
Research01 Oct 2009
Cellular & Molecular Immunology

Volume: 6, P: 367-379
β₂-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Zhao et al. identified β₂-microglobulin (β₂M) as an essential factor driving β-amyloid (Aβ) neurotoxicity and cognitive impairment in mouse models of Alzheimer’s disease (AD) and implicated targeting β₂M–Aβ coaggregation as a strategy for AD therapeutics.

Yini Zhao
Qiuyang Zheng
Xin Wang
Research01 Jun 2023
Nature Neuroscience

Volume: 26, P: 1170-1184
Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.

Zhen Wang
Lijian Xie
Min Huang
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-10
Lens regeneration using endogenous stem cells with gain of visual function

A new procedure for cataract removal that preserves lens epithelial progenitor cells in mammals, which require Pax6 and Bmi1 for their self-renewal, achieves lens regeneration in rabbits, macaques and in infants with cataracts.

Haotian Lin
Hong Ouyang
Yizhi Liu
Research09 Mar 2016
Nature

Volume: 531, P: 323-328
How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Jie Tang
Jing Zhang
Yue Wu
Research31 Mar 2025
Nature Human Behaviour

Volume: 9, P: 1005-1022
Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases

Shengzhang Zheng
Guanqiong Na
Dazhi Chen
ResearchOpen Access10 Oct 2025
npj Science of Food

Volume: 9, P: 1-10
Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Qiang Xu
Su Lui
Yue Wu
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 676-687
Correction: Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function

Haotian Lin
Hong Ouyang
Yizhi Liu
Amendments and Corrections30 Nov 2016
Nature

Volume: 541, P: 558
Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Yin and colleagues show that hepatic aldolase B suppresses hepatocellular carcinoma by controlling tumor metabolic reprogramming through G6PD inhibition.

Min Li
Xuxiao He
Huiyong Yin
Research06 Jul 2020
Nature Cancer

Volume: 1, P: 735-747
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion

Cell–cell adhesion molecules and the cytoskeleton determine endothelial cell shape during the formation of blood vessels. Here the authors show that the scaffold protein, amotL2, couples adherens junctions to contractile cytoskeletal proteins to coordinate cellular morphogenesis with aortic lumen expansion.

Sara Hultin
Yujuan Zheng
Lars Holmgren
Research07 May 2014
Nature Communications

Volume: 5, P: 1-13
Cross-ancestry genome-wide association studies of brain imaging phenotypes

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Jilian Fu
Quan Zhang
Yue Wu
Research29 May 2024
Nature Genetics

Volume: 56, P: 1110-1120
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Nana Liu
Longjiang Zhang
Yue Wu
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1126-1137
Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism

This study elucidates key metabolites and immune cell traits associated with hypothyroidism. These findings provide new insights into the etiology and potential therapeutic targets for hypothyroidism.

Shengzhang Zheng
Lihua Liu
Yujuan Shan
ResearchOpen Access14 Aug 2024
Communications Biology

Volume: 7, P: 1-10
Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis

Yujuan Zheng
Yuanyuan Zhang
Lars Holmgren
ResearchOpen Access28 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation

Qian Liu
Guizhu Liu
Ying Yu
ResearchOpen Access06 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-4
Moderate vs. mild cases of overseas-imported COVID-19 in Beijing: a retrospective cohort study

Wenliang Zhai
Zujin Luo
Yingmin Ma
ResearchOpen Access22 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

Ding Ma, Xing Xie, Yongyong Shi and colleagues report a genome-wide association study of cervical cancer in the Han Chinese population. They identify two new susceptibility lociat 4q12 and 17q12.

Yongyong Shi
Li Li
Ding Ma
Research30 Jun 2013
Nature Genetics

Volume: 45, P: 918-922
A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia

Ran Tao
Buhe Jin
Lin He
Research01 May 2006
Journal of Human Genetics

Volume: 51, P: 498-502
AmotL2 integrates polarity and junctional cues to modulate cell shape

Sara Hultin
Aravindh Subramani
Lars Holmgren
ResearchOpen Access08 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Erratum: EBV-induced human CD8⁺ NKT cells synergize CD4⁺ NKT cells suppressing EBV-associated tumors upon induction of Th1 bias

Wei Xiao
Li Li
Yuling He
Amendments and Corrections04 Jul 2011
Cellular & Molecular Immunology

Volume: 8, P: 368
Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc

Yu Zhong
Liting Yang
Wei Xiong
ResearchOpen Access25 Jun 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-13
Impact and mechanism of sulphur-deficiency on modern wheat farming nitrogen-related sustainability and gliadin content

Zitong Yu et al. utilize large-scale field and glasshouse experiments and transcriptomic and metabolomic analyses to explore the impacts of sulphur fertilization on sulphur-deficient wheat crop and its gluten composition. They show that sulphur fertilization increases nitrogen-use efficiency through regulating glutamine synthetase and reduces the amount of gliadin components through mediating the aspartate-family amino acid biosynthesis network.

Zitong Yu
Maoyun She
Wujun Ma
ResearchOpen Access06 Aug 2021
Communications Biology

Volume: 4, P: 1-16
Histone methyltransferase G9a protects against acute liver injury through GSTP1

Yu Zhang
Weili Xue
Ling Zheng
ResearchOpen Access12 Sept 2019
Cell Death & Differentiation

Volume: 27, P: 1243-1258
miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer

Zhigang Wang
Lu Xu
Weiping Min
ResearchOpen Access09 May 2016
Scientific Reports

Volume: 6, P: 1-11
Synergistic suppression of autoimmune arthritis through concurrent treatment with tolerogenic DC and MSC

Rong Li
Yujuan Zhang
Weiping Min
ResearchOpen Access23 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Zhaoyuan Fang
Xiangkun Han
Hongbin Ji
ResearchOpen Access11 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance

Xiuwen Kong
Xinda Wang
Jun Yu
ReviewsOpen Access29 May 2025
Cell Death Discovery

Volume: 11, P: 1-15
HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

Qiu Peng
Lujuan Wang
Qianjin Liao
Reviews15 Dec 2023
Cancer Gene Therapy

Volume: 31, P: 9-17

Search

Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas

Author Correction: Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Pathways from early-life urbanicity to adult neurobehavioral traits via menarche timing

The genetic architecture of brainstem structures

AmotL2 disrupts apical–basal cell polarity and promotes tumour invasion

EBV-Induced Human CD8⁺ NKT Cells Synergise CD4⁺ NKT Cells Suppressing EBV-Associated Tumours Upon Induction of Th1-Bias

β₂-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

Lens regeneration using endogenous stem cells with gain of visual function

How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases

Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

Correction: Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function

Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion

Cross-ancestry genome-wide association studies of brain imaging phenotypes

Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism

Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis

I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation

Moderate vs. mild cases of overseas-imported COVID-19 in Beijing: a retrospective cohort study

A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia

AmotL2 integrates polarity and junctional cues to modulate cell shape

Erratum: EBV-induced human CD8⁺ NKT cells synergize CD4⁺ NKT cells suppressing EBV-associated tumors upon induction of Th1 bias

Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc

Impact and mechanism of sulphur-deficiency on modern wheat farming nitrogen-related sustainability and gliadin content

Histone methyltransferase G9a protects against acute liver injury through GSTP1

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer

Synergistic suppression of autoimmune arthritis through concurrent treatment with tolerogenic DC and MSC

Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance

HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

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