Nature Search

Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression

Fujioka et al. show that, under starvation, yeast Atg1 forms droplets that concentrate autophagy factors, boosting Atg8 lipidation and clustering vesicles. These droplets likely serve as hubs that generate membrane seeds for autophagosome formation.

Yuko Fujioka
Takuma Tsuji
Nobuo N. Noda
Research16 Sept 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2285-2295
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Structural basis of starvation-induced assembly of the autophagy initiation complex

Autophagy initiates with the assembly of a preautophagosomal structure (PAS), triggered by the yeast Atg1 complex. Ohsumi, Noda and colleagues present the crystal structures of Atg13–Atg1 and Atg13–Atg17, revealing how starvation-induced dephosphorylation of Atg13 triggers formationof the Atg1 complex and PAS assembly.

Yuko Fujioka
Sho W Suzuki
Nobuo N Noda
Research04 May 2014
Nature Structural & Molecular Biology

Volume: 21, P: 513-521
Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases

Shinya Ishiko
Tomoko Horinouchi
Kandai Nozu
ResearchOpen Access20 Aug 2020
Scientific Reports

Volume: 10, P: 1-6
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth

Tomohiro Sameshima
Mariko Ashina
Kazumichi Fujioka
ResearchOpen Access09 Jan 2024
Scientific Reports

Volume: 14, P: 1-6
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

Hidewaki Nakagawa and colleagues identify three new genetic loci associated with prostate cancer in Japanese.

Shusuke Akamatsu
Ryo Takata
Hidewaki Nakagawa
Research26 Feb 2012
Nature Genetics

Volume: 44, P: 426-429
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Phase separation organizes the site of autophagosome formation

The pre-autophagosomal structure in yeast is a liquid-like condensate of Atg proteins whose phase separation may have a critical, active role in autophagy.

Yuko Fujioka
Jahangir Md. Alam
Nobuo N. Noda
Research05 Feb 2020
Nature

Volume: 578, P: 301-305
Palladium-Mediated Polymerization of Bifunctional Diazocarbonyl Compounds: Preparation of Crosslinked Polymers by Copolymerization of Bi- and Monofunctional Diazocarbonyl Compounds

Eiji Ihara
Yuko Goto
Kenzo Inoue
Research09 Oct 2009
Polymer Journal

Volume: 41, P: 1117-1123
Gender Differences in the Association between Anthropometric Indices of Obesity and Blood Pressure in Japanese

Masaru Sakurai
Katsuyuki Miura
Hideaki Nakagawa
Research01 Feb 2006
Hypertension Research

Volume: 29, P: 75-80
Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

MEK1 mutations are found in cancer and RASopathies, but their effects remain unclear. Here, the authors reveal a mutant MEK1 structure and qualitative differences in biological properties between the cancer- and RASopathy-associated mutants, providing insights into the pathophysiology, diagnosis, and treatment of these diseases.

Yuji Kubota
Yuko Fujioka
Mutsuhiro Takekawa
ResearchOpen Access13 Jul 2022
Nature Communications

Volume: 13, P: 1-19
Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy

High-speed AFM imaging enables a semiquantitative, realistic description of the dynamic structure of intrinsically disordered proteins.

Noriyuki Kodera
Daisuke Noshiro
Toshio Ando
Research23 Nov 2020
Nature Nanotechnology

Volume: 16, P: 181-189
Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7

The enzymes involved in autophagy-related UBL conjugation bear only passing resemblance to their counterparts in the better-known UBL conjugation pathways. New structural work provides insight into the mechanism by which the UBL proteins Atg8 and Atg12 are correctly charged by a single activating enzyme, Atg7, then transferred onto their cognate E2 proteins, Atg3 and Atg10, respectively.

Masaya Yamaguchi
Kazuaki Matoba
Fuyuhiko Inagaki
Research11 Nov 2012
Nature Structural & Molecular Biology

Volume: 19, P: 1250-1256
Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial

Hidenori Yamasue
Takashi Okada
Hirotaka Kosaka
Research29 Jun 2018
Molecular Psychiatry

Volume: 25, P: 1849-1858
Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders

Hidetsugu Komeda
Hidekazu Osanai
Hirotaka Kosaka
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Immune activation during the implantation phase causes preeclampsia-like symptoms via the CD40–CD40 ligand pathway in pregnant mice

Keiichi Matsubara
Yuko Matsubara
Takashi Matsumoto
ResearchOpen Access14 Jan 2016
Hypertension Research

Volume: 39, P: 407-414
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Evaluation of the second-generation whole-heart motion correction algorithm (SSF2) used to demonstrate the aortic annulus on cardiac CT

Yoriaki Matsumoto
Chikako Fujioka
Kazuo Awai
ResearchOpen Access03 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Antibody-free digital influenza virus counting based on neuraminidase activity

Kazuhito V. Tabata
Yoshihiro Minagawa
Hiroyuki Noji
ResearchOpen Access31 Jan 2019
Scientific Reports

Volume: 9, P: 1-13
Comprehensive analysis of syndromic hearing loss patients in Japan

Michie Ideura
Shin-ya Nishio
Shin-ichi Usami
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-13
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13

Search

Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Mapping the human genetic architecture of COVID-19

Structural basis of starvation-induced assembly of the autophagy initiation complex

Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

A second update on mapping the human genetic architecture of COVID-19

Phase separation organizes the site of autophagosome formation

Palladium-Mediated Polymerization of Bifunctional Diazocarbonyl Compounds: Preparation of Crosslinked Polymers by Copolymerization of Bi- and Monofunctional Diazocarbonyl Compounds

Gender Differences in the Association between Anthropometric Indices of Obesity and Blood Pressure in Japanese

Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy

Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial

Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders

Immune activation during the implantation phase causes preeclampsia-like symptoms via the CD40–CD40 ligand pathway in pregnant mice

Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Evaluation of the second-generation whole-heart motion correction algorithm (SSF2) used to demonstrate the aortic annulus on cardiac CT

Antibody-free digital influenza virus counting based on neuraminidase activity

Comprehensive analysis of syndromic hearing loss patients in Japan

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Search

Quick links

Search

Filter By:

Search

Quick links