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Previous structural studies of T cell recognition of SARS-CoV-2 have been confined to spike epitopes. Here the authors assess T cell recognition of SARS-CoV-2 nucleocapsid epitopes, which are more conserved than spike epitopes, providing structural insights into recognition of two epitopes.

By reconstituting and visualizing mammalian transcription elongation at the single-molecule level, Wang et al. dissected the effects of individual elongation factors on the speed of RNA polymerase II, which is found to operate as a multi-gear molecular machine.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The authors synthesize rock-salt-structured LiMnSbTe₃, in which Sb₂Te₃-type van der Waals-like gaps are embedded as ordered local structures that both scatter phonons and enhance charge-carrier transport.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

This protocol describes a flexible workflow for joint profiling of chromatin accessibility and transcriptomes in single nuclei, compatible with either plate or droplet single-cell isolation platforms.

Ethylene glycol is commercially produced from ethylene under energy-intensive thermocatalytic conditions. Now a cascade electrochemical heterogeneous system can produce ethylene glycol from ethylene or from CO₂ under ambient conditions using electrocatalytically generated H₂O₂ and an integrated catalyst/solid-acid composite.

The strong scattering of biological tissue causes challenges when monitoring temperature changes at the microscale. Here, the authors propose a nanothermometer based on lanthanide luminescence, enabling minimally invasive imaging of the cerebrovascular system of mice at nearly 200 μm resolution.

The discovery of 2023 KQ₁₄, a Sedna-like object with a perihelion of 66 au, fills a gap in the known population. Its orbit does not align with other Sedna-like objects, shedding light on the diversity and dynamical history of the outer Solar System.

The zoonotic parasite Toxoplasma has complex developmental programs to accommodate different lifestyles that are important for parasite transmission and pathogenesis. Here, the authors discover a novel chromatin remodeling complex containing SNF2L in Toxoplasma and report its crucial roles in regulating the parasite’s developmental programs.

Developing depolymerizable and recyclable polymers with high light-emitting efficiencies is of vital importance for sustainable photonic technologies, but remains challenging. Here the authors design a strategy to develop such polymers based on the use of controllable cleavable moiety.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Galectins play vital roles in cellular functions, yet their unconventional secretion mechanisms are not fully understood. Here, Zhang et al. report that ATG9A vesicles, typically linked to autophagy, serve as carriers for galectin-9 secretion.

This study discovered non-monotonic variations in river flows for seven rivers originating from the Tibetan Plateau at warming levels of 1.5 °C, 2.0 °C, and 3.0 °C, which then resulted in different consequences for riparian countries

In some contexts, rapid detection of COVID-19 from CT scans can be crucial for optimal patient management. Here, the authors present a Deep Learning system for this task with multi-center data, human reader comparison and age stratified results.

Electroreduction of CO₂ to fuels and chemicals is promising but hindered by its low energy efficiency. Here, the authors develop Cu/Ga bimetallic catalysts with reduced activation energies to mitigate the high concentration overpotential, thereby achieving high energy efficiency for CO₂ reduction.

Efficient metabolic regulation is key for parasite growth. Here, the authors report that Toxoplasma alters its AMPK phosphorylation during the lytic cycle, which reprograms parasite’s metabolism to ensure metabolic needs at different stages are met.

An open resource comprising chest computed tomography images and 130 clinical features of 1,521 patients with pneumonia, including COVID-19 pneumonia, facilitates the prediction of morbidity and mortality outcomes via deep learning.

ISSAAC-seq offers a sensitive and modular tool for joint profiling gene expression and chromatin accessibility in single cells.

Nanoparticle clearance is critical for safety and therapeutic applicability. Here the authors report the modulatory role of microglial extracellular vesicles on the brain clearance of organic and inorganic nanoparticles and provide a strategy to control their intracerebral fate.

Robust hydrogels offer a promising solution for the development of artificial skin for bionic robots, yet few hydrogels have a comprehensive performance comparable to real human skin. Here, the authors present a general method to convert traditional elastomers into tough hydrogels via a unique radiation-induced penetrating polymerization method.

The application of quantum computing to computational chemistry faces various experimental and theoretical challenges. Now, a quantum simulation on a noisy quantum device has achieved chemical accuracy for small H₂ and LiH molecules.

The exclusion of cytotoxic T cells remains an important barrier to the efficacy of immunotherapies. Here the authors demonstrate that the combination anti-fibrosis agents and immune-enhanced cytokines can enhance T cell infiltration in a mouse model of pancreatic cancer.

Photoelectrochemical oxidation provides a promising strategy for glucaric acid production. Here, selective oxidation of glucose to glucaric acid is realized on the photoanode of defective TiO2 decorated with single-atom Pt via a photoelectrochemical strategy.

Monopogen identifies single-nucleotide variants in single-cell sequencing data.

Fu, Mackowiak et al. show that cooperative action of the liver and the gut, rather than the liver alone, drives acetaldehyde clearance after alcohol consumption and modulates drinking behaviour.

Glioblastoma (GBM) is characterized by local and systemic immunosuppression, showing limited responses to immunotherapies. Here the authors describe the design of a nanoplatform composed of the lymphopenia alleviating agent cannabidiol and the lymphocyte recruiting cytokine LIGHT, promoting anti-tumor immune responses in GBM preclinical models.

Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Here, the authors show that a systemic metastasis-targeted nanotherapeutic may offer a powerful adjunct therapy for suppressing tumor metastasis.

In a systematic review and meta-analysis of 90 prospective cohort studies, Wang et al. find a significant association of both social isolation and loneliness with increased risk of all-cause mortality.

Strong-field laser surface passivation achieves orders of magnitude reduction in the corrosion rate of stainless steels.

Alkene epoxidation, whose products are important intermediates for the manufacture of pharmaceuticals and epoxy resins, has attracted extensive attention. Unlike the conventional electrochemical Br⁻/Br₂-mediated epoxidation, here the authors report a photoelectrochemical Br⁻/BrO⁻- mediated system to achieve efficient epoxidation performance on α-Fe₂O₃.

Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transient and structurally diverse oligomeric pores in cell membranes.