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Supported single atoms are promising catalysts for alkane dehydrogenation, although tuning their reactivity via active site modulation remains a challenge. Here the authors introduce an Ir₁–Cu₁ dual-atom catalyst for n-butane dehydrogenation that outperforms the corresponding Ir₁ single-atom system.

Authors report on restructuring the electronic structure of a high-nickel material by substituting Li⁺ ions with Y³⁺ ions. This strategy suppresses the generation of oxygen defects with a reduction coupling mechanism improving high-voltage stability.

The authors report the large low-field-driven electrocaloric effect in the novel organic-inorganic hybrid TMCM-CdCl₃, underlyingly from the disordering of organic cations and the low-symmetry interaction induced two-step meta-electric transition.

Individual antibodies identified in the blood of people triple-vaccinated against SARS-CoV-2 predominantly bind spike protein and are highly effective at neutralizing SARS-CoV-2 variants, including Omicron (B.1.1.529).

Metabolites are indicators of health and disease; genetic studies can reveal variants influencing their levels. Here, the authors investigate the contribution of rare, exonic variants on the levels of urine metabolites and generate predictions on metabolic consequences underlying metabolic disease.

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Mechanistic insights into Cryptosporidium parvum invasion identify a non-canonical role for Protein Disulfide Isomerase through interaction with host keratin 18.

The role of hydrophobic interactions in the regulation of the handedness of peptide superstructures is unknown. Here, the authors show that aromatic side chains set the twisting directions of the single β-strands of peptide amphiphiles.

Chen et al. report a large-area white LED with sunlight-like emission by regulating the heterophase γ/σ-CsPb(I/Cl)₃ at nanoscale, in which a fraction of carriers recombines in γ-CsPbI₃ for deep-red emission, while other carriers diffuse to the heterophase interface for broadband emission.

High-temperature deformation of materials is challenging to evaluate. Here the authors develop a novel device that allows atomic resolved in situ high temperature mechanical tests inside a transmission electron microscope and reveal ductile fracture of a single crystal tungsten deformed at 973 K.

Chen et al. show that the endoplasmic reticulum stress sensor IRE1α acts in white and beige adipocytes to restrain beige adipocyte activation, through regulation of lipolysis and Pgc1α messenger RNA levels, respectively.

A four-dimensional printable shape memory hydrogel with shape-shifting onset adjustable by changing the programming conditions is reported.

The researchers fuse metamaterials and origami technical to achieve ultra-wideband and large-depth reflection modulation. Flexible electronics amplify its lightweight, transparency, and cost-effectiveness, making it ideal for satellite communications.

Plants employ developmental strategies to avoid shade and compete with neighbors for light. Here, Xie et al. show that phytochrome-interacting factors, which are regulated in a light-dependent manner, directly repress MIR156 genes and promote the expression of SPL genes to enhance shade-avoidance responses.

This study shows that the Indian Ocean significantly affects North American winter climate through Rossby wave dynamics. During its warm phase, this teleconnection drives an eastern warming – western cooling anomaly in North America, along with snowfall changes.

Chiral interaction of molecular ensembles with confined light fields is elusive. Here, the authors report collective chiroptical effects through coupling of exciton and charge-transfer mixed molecular assemblies with plasmonic nanoparticles.

Brain-wide axonal projections of single neurons have been extensively reconstructed without any functional characterization. The authors present a method that allows for developing a precise one-to-one map of both projection patterns and functional features of single neurons in mice.

The sign of longitudinal piezoelectric coefficients is typically positive. Here, the authors tune the sign of the linear piezoelectric coefficient of HfO₂ from positive to negative via epitaxial strain, finding nonlinear and parabolic piezoelectric behaviors at tensile epitaxial strain.

An abnormal stress memory effect is discovered in different types of glassy materials when they are subjected to a low strain after a high strain. This strategy can be used to depress the stress relaxation and increase the stability under loading.

Peptide self-assembly is a hierarchical process which includes forming β-sheets but the formation of high ordered structures remains largely unexplored. Here the authors report on a super-secondary structural template, based on well-defined hydrogen bonds by rational design and assembly of short peptides

In plants, branching is regulated by both hormones and external cues such as light. Here the authors show that in Arabidopsis, the phytochrome A-signaling components FHY3 and FAR1, and SMXL proteins that repress strigolactone signaling, both interact with SPL proteins to control expression of the branching regulator BRC1.

Two types of skyrmion-like polar nanodomain are observed in oxide bilayers transferred onto silicon, and these nanodomains, with distinct resistive behaviour, can be converted to each other under an external electric field.

Ultrasound-induced luminescence enables in vivo molecular imaging of tumours and lymph nodes with spatial resolution of 1.46 mm.

Gate-type field emission cathodes based on carbon nanotubes face challenges of achieving high E-beam transmittance to avoid the collision with the gate to form irreversible damages. Here, the authors present a self-charging gate to control the E-beam trajectory by inducing a local electric field.

Simultaneous increase of mechanical and physical properties is highly desirable, but challenging for bimetallic materials. Here, the authors use W-Cu as an example to achieve both high strength and conductivity of the bimetal with a large plasticity by a self-assembled lamellar architecture.

Eyewitness errors contribute to wrongful convictions. Here, the authors present a lineup procedure that reveals the structure of eyewitness memory, reduces decision bias, and measures performance of individual witnesses.

CMD-GEN is a structure-based framework for selective inhibitor design, combining coarsegrained pharmacophore sampling with generative models to optimize molecular stability, druglikeness, and binding interactions in drug discovery.

The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function.

Genome-wide association analysis for morphological traits across 350 elite maize inbred lines in Chinese and US germplasm identifies loci and genomic regions representing the targets of selection during modern maize breeding.