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Piezoionic materials are integrated into sensors, though many piezoionic materials have unfavorable mechanical properties. Here the authors report a piezoionic eutectogel, optimizing mechanical properties and piezoionic response.

This study reports crystal structures of the ryanodine receptor domain bound to dantrolene and azumolene. The work reveals cooperative nucleotide binding and provides structural insights to guide the design of potent inhibitors targeting the receptor.

Magnetoelectric composites of magnetic and ferroelectric components are promising for their use in applications such as information storage. Here, the authors find that magnetic quasiparticles embedded in a ferroelectric film matrix show promising properties compared to the usual thin-film architectures.

Limited therapeutic options are available for pulmonary fibrosis because its molecular pathogenesis remains unclear. Here, the authors show that the CCL20– integrin α5β1–TGF β signaling cascade could be a potential therapeutic target for pulmonary fibrosis.

SARS-CoV-2 mainly transmits via respiratory droplets. Here Deng et al. show that SARS-CoV-2 can infect rhesus macaques via ocular conjunctival inoculation.

Nano-kirigami is a promising approach to transform 2D precursors into complex 3D architectures. Here, the authors report plastic, elastic, and hysteretic deformations of silicon-based nano-kirigami structures and demonstrate applications in dynamic optical information encryption.

Liquid metal inks are promising for flexible electronics, but it is challenging to produce liquid metal inks due to surface tension and density. Here, the authors design a liquid metal-cryogel system to increase liquid metal concentration.

Loss of tumor suppressor function is one of the major causes of uncontrolled growth of cancer cells. Here authors show that inactivation of the tumor suppressors NF1, TSC1, and TGF-β RII also promotes a non-cell autonomous change in the tumor microenvironment, characterized by inflammatory features and LAG3+ T cell-mediated immune suppression, which are therapeutically targetable.

Pesticide resistance poses a serious threat to global food security. In this study, the authors show the mode of action of various diamide insecticides and elucidate the molecular mechanisms underlying resistance mutations.

Binning is an essential step in genome-resolved metagenomic analysis in which assembled contigs originating from the same source population are clustered. However it is challenging, especially for low abundance microbial species. Here the authors introduce a toolkit that integrates multiple prominent binning tools and AI for efficient and high-resolution recovery of non-redundant bins from short- and long-read metagenomic sequencing datasets.

Magnetized and biohybrid blood hydrogel fibres can be used for magnetically controlled targeted drug delivery into tumours with real-time tracking through X-ray fluoroscopy, as shown for minipigs with intracranial tumours.

Evidence for the treatment of patients with mild-to-moderate COPD is limited. Here, the authors show that long-term treatment with high-dose N-acetylcysteine neither significantly reduced the annual rate of total exacerbations nor improve lung function in patients with mild-tomoderate COPD.

Intercropping has the potential to improve plant nutrition and crop yield. Here, the authors intercrop peanut and maize and show that Pseudomonas secreted siderophore pyoverdine play an important role in plant iron nutrition.

Only a few genetic variants have been identified to mediate salt tolerance in major crops and their molecular mechanisms are largely unknown. Here, the authors identify WRKY53 as a negative regulator of salt tolerance in rice, and show that it directly trans-regulates expression of MKK10.2 and HKT1;5 to meditate salt tolerance.

Population analysis of 516 wild and domesticated broomcorn millet genomes and a graph-based pangenome based on de novo assemblies of 32 representative accessions identify genomic variations associated with domestication traits.

Here, the authors show that single upconversion nanoparticles can generate position-sensitive patterns in the spatial domain when placed on a mirror. They attribute this to the single emitter’s interference with its own mirror image and show how this can be used to obtain axial localisation of the particle.

Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic islet β cells. Here the author show, by comparing the diabetes-sensitive NOD mouse strain with its congenic, diabetes-resistant ALR strain, and by genomic analyses of T1D patients and control, that mutations in the Myo9b gene may alter dendritic cells to contribute to autoimmune diabetes onset.

The diamondback moth, Plutella xylostella is a cosmopolitan agricultural pest. By analyzing 532 genomes from 114 populations around the world, the authors find evidence supporting a South American origin of this moth, and look for signatures of positive selection.

By tracing promoter expression in lineage-mapped single cells, Xu et al. present a whole-body cartography of microRNA transcriptional activities during C. elegans embryogenesis and demonstrate its broad utility in multifaceted functional analyses.

Using cryo-electron microscopy, the directional multiple step mechanism of chitin biosynthesis is revealed.

Current data on the national distribution of diabetic retinopathy (DR) is lacking. Here, the authors show the national distribution, associated multi-level factors, and visual impairment of DR and vision-threatening DR in Chinese adults with diabetes.

Reliable detection of mutations below 0.5% variant allele frequency remains a key challenge for circulating tumor DNA sequencing assays.

Adipose tissue-resident T cells are known to regulate thermogenesis and energy expenditure. Here the authors report that deletion of mitochondria-localized protein DsbA-L in T cells promotes diet-induced thermogenesis via suppressing IFN-γ production.

The C2 sulfonates taurine and isethionate are also present in the anaerobic mammalian gut, where they are converted into toxic H₂S by sulfate and sulfite-reducing bacteria. Here the authors characterise the O₂-sensitive enzyme IseG that catalyzes the C-S bond cleavage of isethionate and show that IseG also plays a key role in converting taurine into H₂S in Bilophila wadsworthia.

Cryo-EM structural work defines binding of the insecticide CHL in the pseudo-voltage-sensor domain of ryanodine receptor RyR that triggers conformational changes leading to channel opening and explains the resistance to CHL by some insects.

The miniaturization of antennas beyond a wavelength is limited by designs which rely on electromagnetic resonances. Here, Nan et al. have developed acoustically actuated antennas that couple the acoustic resonance of the antenna with the electromagnetic wave, reducing the antenna footprint by up to 100.

Cancer cells have altered lipid metabolism. Here the authors show that DAXX promotes lipogenesis and tumorigenesis through interaction with SREBP1/2.

The mechanism of the delocalization transition of 4f electrons in closely-packed Ce metal has been debated. Here, the authors present photoemission evidence for bandwidth-controlled Mott delocalization in a previously unreported structural phase of thin epitaxial Ce films obtained by thermal annealing.

A protein expression atlas of transcription factors charted onto cell lineage maps of Caenorhabditis elegans development that uncovers mechanisms of spatiotemporal cell fate patterning and regulators of embryogenesis.

PIWI-interacting RNAs (piRNAs) are ~25–33 nt small RNAs expressed in animal germ cells. Here, the authors develop a single-cell small RNA sequencing method and report that a class of ~20-nt piRNAs lacking 3′ end 2′-O-methylation are associated with PIWIL3 protein and predominantly expressed in human and monkey oocytes.