Nature Search

General phase segregation and phase pinning effects in lanthanide-doped lead halide perovskite with dual-wavelength lasing

He et al. report a lanthanide-doping strategy for dual-halogen-alloyed perovskite microplates, which promotes phase segregation and facilitates ion migration in the alloyed case, while suppressing it in the phase-segregated state, resulting in dual-wavelength lasing in visible spectral region.

Junyu He
Jun Luo
Xiujuan Zhuang
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 16, P: 1-9
Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells

Jianru Guo
QianQian Chen
Wei Zhang
ResearchOpen Access18 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Author Correction: Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus

Qintao Wang
Honghao Zhu
Zhihong Liu
Amendments and CorrectionsOpen Access10 Oct 2025
Nature

Volume: 647, P: E1
Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression

Ying Li
Liping Chen
Haitao Wu
ResearchOpen Access24 Apr 2025
Cell Death & Differentiation

Volume: 32, P: 1930-1945
Highly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid

Proteolysis-targeting chimeras (PROTACs) hold therapeutic promise but face challenges of high molecular weight, polarity, and poor drug-like properties. Here, authors develop PLA-based SM-PROTACs that achieve efficient target degradation and superior low-dose, long-term tumor inhibition in vivo

Mei-miao Zhan
Hailing Chen
Feng Yin
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-11
SpliceTransformer predicts tissue-specific splicing linked to human diseases

RNA splicing is crucial for gene expression diversity and can be altered by mutations. Here, the authors present SpTransformer, a deep learning tool that predicts tissue-specific RNA splicing with high accuracy, revealing splicing’s role in pathogenic mutations and aiding clinical interpretations.

Ningyuan You
Chang Liu
Ning Shen
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Supercontinuum-tailoring multicolor imaging reveals spatiotemporal dynamics of heterogeneous tumor evolution

Studying tumour heterogeneity and tumour evolution remains a challenging task. Here, the authors propose a supercontinuum-tailoring two-photon microscope to enable the imaging of multiple fluorophores with a single light beam. They use this tool to monitor the dynamics of heterogeneous tumour evolution.

Xiujuan Gao
Xinyuan Huang
Ling Fu
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

In a phase 1 trial, the co-infusion of CD19-targeting and BCMA-targeting CAR-T cells in adults with treatment-refractory lupus was safe and had promising efficacy, with most patients achieving remission after 3 months.

Jingjing Feng
Dawei Huo
He Huang
Research24 Sept 2025
Nature Medicine

Volume: 31, P: 3725-3736
Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus

PLD4 loss-of-function mutations in patients with systemic lupus erythematosus leads to excessive activation of TLR7 and TLR9.

Qintao Wang
Honghao Zhu
Zhihong Liu
ResearchOpen Access10 Sept 2025
Nature

Volume: 647, P: 498-505
Decoding single-crystal lithium growth through solid electrolyte interphase omics

Understanding the impact of the solid electrolyte interphase (SEI) on lithium deposition is crucial for developing high-energy lithium metal batteries. Here, authors elucidate the multi-scale effects of the SEI on lithium deposition behavior based on the established SEI-omics framework.

Gongxun Lu
Zhiyuan Han
Guangmin Zhou
ResearchOpen Access22 Oct 2025
Nature Communications

Volume: 16, P: 1-12
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Synthesis of valuable benzenoid aromatics from bioderived feedstock

Aromatic chemicals, having indispensable roles in human society, are currently produced from fossil resources. Here, the authors introduce a strategy to synthesize benzenoid aromatics from bio-based feedstock, showing the possibility of phasing out fossil-based feedstocks in aromatics production.

Shasha Zheng
Zhihong Wei
Johannes G. de Vries
ResearchOpen Access10 Aug 2023
Nature Sustainability

Volume: 6, P: 1436-1445
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound PLpro crystal structure and NMR studies.

Ziyang Fu
Bin Huang
Hao Huang
ResearchOpen Access20 Jan 2021
Nature Communications

Volume: 12, P: 1-12
The role of alkali metal cations and platinum-surface hydroxyl in the alkaline hydrogen evolution reaction

Platinum is the most active catalyst for the hydrogen evolution reaction, but the specific mechanism and the influence of the alkali metal cations remain elusive in alkaline media. Now, electrical transport spectroscopy, electrochemical impedance spectroscopy and ab initio molecular dynamics simulations are combined to elucidate the role of alkali metal cations for this reaction in alkaline electrolyte.

Aamir Hassan Shah
Zisheng Zhang
Xiangfeng Duan
Research19 Oct 2022
Nature Catalysis

Volume: 5, P: 923-933
Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease

The mechanisms underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) are unknown. Herein, the authors reveal that alcohol-induced microbial reorganization and resultant elevation in GMM phenylacetylglutamine, directly contributes to CVD.

Zhen Li
Min Gu
Thomas E. Sharp III
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-23
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Jingyun Yang
Wei Wang
Xiawei Wei
Research29 Jul 2020
Nature

Volume: 586, P: 572-577
A comprehensive genome variation map of melon identifies multiple domestication events and loci influencing agronomic traits

A comprehensive map of genomic variation in melon derived from resequencing of 1,175 accessions sheds light on the population structure and domestication history of melon and agronomic traits for melon breeding.

Guangwei Zhao
Qun Lian
Sanwen Huang
Research01 Nov 2019
Nature Genetics

Volume: 51, P: 1607-1615
Cloud behaviour on tidally locked rocky planets from global high-resolution modelling

A high-resolution global climate simulation of tidally locked rocky planets orbiting around M dwarfs with explicit convection resolves the behaviour of their clouds, determining the cloud properties and suggesting the frequent appearance of cloud streets affecting the planetary energy balance.

Jun Yang
Yixiao Zhang
Zhihong Tan
Research19 Jun 2023
Nature Astronomy

Volume: 7, P: 1070-1080
Regeneration of Liangzhu culture: multimedia exhibition, simulated restoration, innovative cultural products, nearby area integration, virtual reality and augmented reality

Zhihong Liu
ResearchOpen Access03 Jul 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-18
Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma

The heterogeneity of cell-of-origin for papillary renal cell carcinoma (pRCC) remains unknown. Here, with single-cell ATAC-seq from normal human kidney cells and ATACseq profiles from pRCC samples, the authors show that pRCC can originate from kidney collecting duct principal cells and this subtype is associated with advanced pRCC.

Qi Wang
Yang Zhang
Jingping Yang
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-12
Metal telluride nanosheets by scalable solid lithiation and exfoliation

Fast and scalable synthesis of a variety of transition metal telluride nanosheets by solid lithiation and hydrolysis is demonstrated and several interesting quantum phenomena were observed, such as quantum oscillations and giant magnetoresistance.

Liangzhu Zhang
Zixuan Yang
Hui-Ming Cheng
Research03 Apr 2024
Nature

Volume: 628, P: 313-319
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions.

Xiaoxiao Yuan
Ruirui Wang
Feihong Luo
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Machine learning model optimization with optuna for accurate prediction of strength and crack behavior in prestressed concrete beams

Yuanyong Wen
Rongxin Guo
Chaoshu Fu
ResearchOpen Access20 Jan 2026
Scientific Reports

Volume: 16, P: 1-15
A cluster of Zika virus infection in a Chinese tour group returning from Fiji and Samoa

Jimin Sun
Tao Fu
Enfu Chen
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Continuous epitaxy of single-crystal graphite films by isothermal carbon diffusion through nickel

Isothermal dissolution–diffusion–precipitation of carbon drives continuous epitaxial growth of single-crystal multilayer graphene.

Zhibin Zhang
Mingchao Ding
Kaihui Liu
Research27 Oct 2022
Nature Nanotechnology

Volume: 17, P: 1258-1264
Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang
Wei Wang
Xiawei Wei
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E23
Time frequency analysis of elastic wave PSO OMP for defects in flat steel of down conductors

Jing Zhang
Wei Liu
Zhihong Fu
ResearchOpen Access20 May 2025
Scientific Reports

Volume: 15, P: 1-15
Oncogene PRR14 promotes breast cancer through activation of PI3K signal pathway and inhibition of CHEK2 pathway

Xiaolei Ren
Meijun Long
Mei Yang
ResearchOpen Access15 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-16
Expert consensus on digital restoration of complete dentures

Yue Feng
Zhihong Feng
Lina Niu
ReviewsOpen Access30 Jul 2025
International Journal of Oral Science

Volume: 17, P: 1-11
A graph self-supervised residual learning framework for domain identification and data integration of spatial transcriptomics

A graph self-supervised residual learning framework (ResST) for natural domain identification and data integration of spatial transcriptomics.

Jinjin Huang
Xiaoqian Fu
Youmei Peng
ResearchOpen Access12 Sept 2024
Communications Biology

Volume: 7, P: 1-15
Clinicopathologic and molecular features in hairy cell leukemia-variant: single institutional experience

Evgeniya A. Angelova
L. Jeffrey Medeiros
Rashmi Kanagal-Shamanna
Research28 Jun 2018
Modern Pathology

Volume: 31, P: 1717-1732
Improvement of awareness, treatment and control of hypertension among chronic kidney disease patients in China from 1999 to 2005

Yu Wang
Luxia Zhang
Hai Yan Wang
Research04 Jun 2009
Hypertension Research

Volume: 32, P: 444-449
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Binfeng Liu
Wei Li
Zhihong Li
ResearchOpen Access21 May 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-17
Epidemiological characteristics of patients with Hutchinson-Gilford progeria syndrome and progeroid laminopathies in China

Jingjing Wang
Qinmei Yu
Jianhua Mao
Research08 Jan 2024
Pediatric Research

Volume: 95, P: 1356-1362
SRSF1 plays a critical role in invariant natural killer T cell development and function

Jingjing Liu
Menghao You
Shuyang Yu
Research14 Sept 2021
Cellular & Molecular Immunology

Volume: 18, P: 2502-2515
Pan-cancer analysis reveals the prognostic and immunotherapeutic value of cytoskeleton-associated protein 2-like

Bocun Yi
Qingfeng Fu
Zhihong Zhang
ResearchOpen Access24 May 2023
Scientific Reports

Volume: 13, P: 1-19
A prognostic signature based on genes associated with m6A/m5C/m1A/m7G modifications and its immunological characteristics in clear cell renal cell carcinoma

Wei He
Zixiang Cong
Qiang Fu
ResearchOpen Access12 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
Mechanical mechanism analysis of rockburst in deep-buried tunnel with high in-situ stress

Chao Zhou
Zhihong Dong
Sheng Luo
ResearchOpen Access05 Aug 2024
Scientific Reports

Volume: 14, P: 1-16
Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma

Zhihong Yao
Lei Han
Zuozhang Yang
ReviewsOpen Access13 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-12
Optical neural networks: progress and challenges

Tingzhao Fu
Jianfa Zhang
Hongwei Chen
ReviewsOpen Access20 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-25
SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells

Wang et al. find that the therapeutic agent cisplatin has opposite effect on acetylation of serine-arginine protein kinase 1 (SRPK1) in cisplatin-resistant versus – sensitive breast cancer cells. Inhibiting SRPK1 activity or enhancing its acetylation re-sensitises cells to cisplatin, suggesting a potential strategy to treat cancers resistant to platinum-based therapy.

Cheng Wang
Zhihong Zhou
Qidong Hu
ResearchOpen Access27 May 2020
Communications Biology

Volume: 3, P: 1-13
Artificial intelligence defines protein-based classification of thyroid nodules

Yaoting Sun
Sathiyamoorthy Selvarajan
Tiannan Guo
ResearchOpen Access06 Sept 2022
Cell Discovery

Volume: 8, P: 1-17
Low membranous expression of β-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary

Daniel G Rosen
Zhihong Zhang
Jinsong Liu
Research09 Oct 2009
Modern Pathology

Volume: 23, P: 113-122
Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3

Chuanhai Fu
Kashif Ahmed
Xuebiao Yao
Research23 May 2005
Oncogene

Volume: 24, P: 5401-5413

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