Nature Search

DNA StairLoop: enabling high-fidelity data recovery and robust error correction in DNA-based data storage

High-throughput electrochemical synthesis is ideal for DNA storage, but suffers from low fidelity. Here, authors propose a coding scheme named DNA StairLoop. Experiments demonstrate that it can recover data with high error rates and low sequencing depths, improving the practicality of this technique.

Zihui Yan
Guanjin Qu
Huaming Wu
ResearchOpen Access16 Oct 2025
Nature Communications

Volume: 16, P: 1-10
The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic paraventricular nucleus in male mice

Jiayin Yue
Qilun Zhang
Wei Wang
ResearchOpen Access19 Mar 2026
Translational Psychiatry

Volume: 16, P: 1-13
Stereotactic body radiotherapy versus laparoscopic liver resection for single hepatocellular carcinoma ≤ 5 cm: a retrospective, multicenter, cohort study

Bin Zhou
Zihui Ma
Weixing Guo
ResearchOpen Access18 Nov 2025
Scientific Reports

Volume: 15, P: 1-11
Driving pressure guided ventilation with lung ultrasound reduces pulmonary complications after epigastric surgery at high altitude

Zihui Xu
Chunyan Dou
Ke Chen
ResearchOpen Access12 Feb 2026
Scientific Reports

Volume: 16, P: 1-11
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Parallel comparison of T cell and B cell subpopulations of adenoid hypertrophy and tonsil hypertrophy of children

Adenoids and tonsils in children can become hypertrophic because of multiple infections. Here the authors use single cell transcriptomics to assess the immune cell composition of these hypertrophic organs and find B, T and NK cells and exhausted memory CD4 T cells indicating immune changes in these organs associated with respiratory infection.

Zihui Yu
Ziying Xu
Jing Yuan
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-19
DNA data storage for biomedical images using HELIX

A DNA-based storage system for biomedical images is proposed, combining compression, error correction and deep learning repair. It achieves 97.20% image quality at 7× coverage depth, demonstrating high compression and fault tolerance.

Guanjin Qu
Zihui Yan
Huaming Wu
Research13 May 2025
Nature Computational Science

Volume: 5, P: 397-404
Modeling post-gastrula development via bidirectional pluripotent stem cells

Kuisheng Liu
Zihui Yan
Wenqiang Liu
Research29 Aug 2025
Cell Research

Volume: 35, P: 954-969
Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy

Nanozymes offer diverse therapeutic avenues for cancer treatment. In this work, the authors report an iron-based quasi-metal organic framework nanozyme Q-MIL-53(Fe) with enhanced peroxidase and catalase-mimicking activity and glutathione depletion capacity and use it for tumor immunotherapy via inducing ferroptosis and immunogenic cell death.

Zihui Yan
Yang Bai
Jianhao Wang
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae

Previous studies have shown that high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the intestinal microbiome could be one of the causes of non-alcoholic fatty liver disease (NAFLD). Here, the authors show the effectiveness of phage in mice with HiAlc Kpn-induced NAFLD indicating phage therapy targeting gut microbiota may be an alternative to antibiotics, with potential efficacy and safety.

Lin Gan
Yanling Feng
Jing Yuan
ResearchOpen Access03 Jun 2023
Nature Communications

Volume: 14, P: 1-15
m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging

The authors characterized m⁶A dynamics in primate tissue aging and revealed a new role for the METTL3–m⁶A–NPNT axis in maintaining skeletal muscle homeostasis, thereby providing insight into the epitranscriptomic machinery underlying primate aging.

Zeming Wu
Mingming Lu
Guang-Hui Liu
Research06 Apr 2023
Nature Aging

Volume: 3, P: 705-721
Efficacy of hyperthermic intrathoracic chemotherapy for initially diagnosed lung cancer with symptomatic malignant pleural effusion

Zihui Li
Jie Deng
Jianhai Sun
ResearchOpen Access26 Jul 2023
Scientific Reports

Volume: 13, P: 1-7
Ultrafast photoinduced dynamics of a donor-(\(\mathrm \pi\))bridge-acceptor based merocyanine dye

Jianwei Shen
Ajay Jha
Zhenrong Sun
ResearchOpen Access29 Oct 2022
Scientific Reports

Volume: 12, P: 1-10
A genotype-first analysis in a cohort of Mullerian anomaly

Weijie Tian
Na Chen
Lan Zhu
Research13 Jan 2022
Journal of Human Genetics

Volume: 67, P: 347-352
Decitabine promotes the differentiation of poorly differentiated gastric cancer cells and enhances the sensitivity of NK cell cytotoxicity via TNF-α

Man Lv
Yue Wang
Run Xiao
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Identification of novel FBN1 variations implicated in congenital scoliosis

Mao Lin
Sen Zhao
Nan Wu
ResearchOpen Access11 Dec 2019
Journal of Human Genetics

Volume: 65, P: 221-230
Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine

Congenital vertebral malformation has a complex genetic architecture that isn’t fully understood. Here, the authors explore the genetic architecture of congenital vertebral malformation through case-control rare variant genetic analyses and embryonic transcriptome analyses of the developing spine.

Sen Zhao
Hengqiang Zhao
Nan Wu
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-9
Silicon improves ion homeostasis and growth of liquorice under salt stress by reducing plant Na⁺ uptake

Zihui Shen
Xiaozhen Pu
Moxiang Cheng
ResearchOpen Access24 Mar 2022
Scientific Reports

Volume: 12, P: 1-13
Inhibition of the ATP synthase increases sensitivity of Escherichia coli carrying mcr-1 to polymyxin B

Zheng Fan
Zhoufei Li
Jing Yuan
Research24 Jun 2024
The Journal of Antibiotics

Volume: 77, P: 685-696
Expanding the mutation and phenotype spectrum of MYH3-associated skeletal disorders

Sen Zhao
Yuanqiang Zhang
Nan Wu
ResearchOpen Access15 Feb 2022
npj Genomic Medicine

Volume: 7, P: 1-11
Whole-exome sequencing reveals known and novel variants in a cohort of intracranial vertebral–basilar artery dissection (IVAD)

Kun Wang
Sen Zhao
Xinjian Yang
ResearchOpen Access16 Aug 2018
Journal of Human Genetics

Volume: 63, P: 1119-1128
TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model

Jiaqi Liu
Nan Wu
Guixing Qiu
Research14 Jan 2019
Genetics in Medicine

Volume: 21, P: 1548-1558
The prevalence and associated factors of metabolic syndrome in Chinese aging population

Huisheng Ge
Zihui Yang
Xixi Wu
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-10

Search

DNA StairLoop: enabling high-fidelity data recovery and robust error correction in DNA-based data storage

The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic paraventricular nucleus in male mice

Stereotactic body radiotherapy versus laparoscopic liver resection for single hepatocellular carcinoma ≤ 5 cm: a retrospective, multicenter, cohort study

Driving pressure guided ventilation with lung ultrasound reduces pulmonary complications after epigastric surgery at high altitude

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

Parallel comparison of T cell and B cell subpopulations of adenoid hypertrophy and tonsil hypertrophy of children

DNA data storage for biomedical images using HELIX

Modeling post-gastrula development via bidirectional pluripotent stem cells

Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy

Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae

m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging

Efficacy of hyperthermic intrathoracic chemotherapy for initially diagnosed lung cancer with symptomatic malignant pleural effusion

Ultrafast photoinduced dynamics of a donor-(\(\mathrm \pi\))bridge-acceptor based merocyanine dye

A genotype-first analysis in a cohort of Mullerian anomaly

Decitabine promotes the differentiation of poorly differentiated gastric cancer cells and enhances the sensitivity of NK cell cytotoxicity via TNF-α

Identification of novel FBN1 variations implicated in congenital scoliosis

Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine

Silicon improves ion homeostasis and growth of liquorice under salt stress by reducing plant Na⁺ uptake

Inhibition of the ATP synthase increases sensitivity of Escherichia coli carrying mcr-1 to polymyxin B

Expanding the mutation and phenotype spectrum of MYH3-associated skeletal disorders

Whole-exome sequencing reveals known and novel variants in a cohort of intracranial vertebral–basilar artery dissection (IVAD)

TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model

The prevalence and associated factors of metabolic syndrome in Chinese aging population

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