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Foamy macrophages are key to atherosclerosis but poorly understood. Here, the authors show that GPNMB regulates lipoprotein processing in macrophages, exacerbating pathological lipid accumulation, and revealing it as a therapeutic target whose inhibition reduces atherosclerosis in mice.

Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.

Zhu et al. combine neonatal and twin imaging to unveil innate functional connectivity patterns in the temporal pole, a hub region for semantic memory. These patterns are present in neonates, heritable, and linked to semantic functions in adults.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

There remains a critical need for precise control of CRISPR-based technologies. Here, the authors develop a focused ultrasound (FUS)-controllable CRISPR toolbox, allowing the noninvasive and spatiotemporal control of genomic/epigenomic reprogramming for cancer treatment combined with CAR-T therapy.

Imaging non-repetitive loci in living cells remains challenging. Here, the authors engineered an inducible system whereby biomolecular assemblies can be guided to specific genomic loci by a nuclease-defective Cas9, allowing the simultaneous imaging and manipulation of the loci.

A remora-inspired mechanical underwater adhesive device adheres securely to a range of soft substrates and maintains performance under extreme pH and moisture conditions, with potential applications in biosensing and drug delivery.

This study identifies SCEP3 as a conserved central element of the plant synaptonemal complex. SCEP3 is critical for synapsis, heterochiasmy and crossover interference. SCEP3 also promotes a subset of crossover events.

Nano-environmental probes and advance imaging microscopy provide deep insight into protein phase separation and the interaction of condensates with membranes, revealing that wetting by condensates can modulate membrane lipid packing and hydration.

The authors resolved large scale fresh and recirculated submarine groundwater discharge (SGD) and their associated nutrient fluxes in China’s coastal seas, revealing a dominant role of SGD in nutrient budgets.

Analysis of bacterial, archaeal, fungal and viral species in the gut microbiome of patients with colorectal cancer identified cross-kingdom interactions and multi-kingdom markers of disease.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

The use of electric fields to control spin currents, which is one of the goals of modern spintronics, has now been extended to control the valley degree of freedom in a 2D semiconductor.

A single-cell transcriptomic study from the Human Cell Atlas integrating over 11 million brain cells from 70 studies uncovers differences across human brain regions and identifies rare progenitor and microglia subtypes.

Synthesizing precise conjugated nanostructures on a surface requires fine control over the covalent reaction pathways. Here, the authors show that reversible coordinative bonds can be used to template on-surface C-C coupling reactions, guiding the formation of porous organic nanoribbons.

IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3 suppresses IFITM1 via the degradation-related protein DDX5.

Membrane fission of a cell into two daughters is a core ability of cell-based life. Here the authors show that in artificial cells division can be controlled by regulating membrane curvature using low protein density.

In this work, the authors investigated on the interaction of biomolecular condensates with membranes and report that they can exhibit two wetting transitions modulated by membrane or milieu composition. Condensate adhesion can trigger intriguing ruffling of the membrane interface into complex finger-like structures.

A Single Particle Tracking parameter optimization pipeline for MINFLUX microscopy.

Association analyses using resting-state functional magnetic resonance images identify common genetic variants influencing intrinsic brain activity. Variation in brain function is genetically correlated with several neuropsychiatric traits.

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

Nanocatalysts and single‐atom catalysts are generally considered as two categories with distinct performances. Here, in situ TEM study of catalytic methane pyrolysis over nanoporous Au reveals a highly dynamic process where co‐catalysis exists among various catalyst forms.

Arrays of vertical nanopillars are used to study the deformability of the cell nucleus and its mechanical coupling with the cell membrane.

A variety of artificial cells springs from the functionalization of liposomes with proteins but these models suffer from low durability without repair and replenishment mechanisms. Here, the authors show that synthetic amphiphile membranes undergo SNARE-mediated fusion, and determine bending rigidity and pore edge tension as key parameters for fusion.

Genome-wide analyses in 19,629 individuals identify 365 independent variants associated with brain volumetric phenotypes. The study provides insight into the overlapping genetic architecture of brain volume measures and cognitive and mental health traits.

Viscoelasticity of PEG in aqueous solutions containing different concentrations of K₂SO₄ was studied by QCM-D, after coating a rigid supported lipid bilayer on the silicon oxide substrate. The obtained viscoelastic properties of PEG in K₂SO₄ solutions agree well with the Zimm model predictions for linear polymer chains. The gradual worsening of solvent quality by adding K₂SO₄ to aqueous PEG solutions is demonstrated by the obtained excluded volume exponents via QCM-D and the conventional intrinsic viscosity measurements.