Induced pluripotent stem cells articles from across Nature Portfolio

CAR-T therapy remains poorly effective in glioblastoma (GBM) due to the tumor’s high antigen heterogeneity and immunosuppressive microenvironment. This study reports a multimodal platform for GBM immunotherapy that combines dual-antigen oncolytic viruses with bispecific CAR-T (BiCAR-T) and CAR-NK cells.

Here authors show in a human stem cell–derived model, neural cultures from children with MPSIIIA exhibit hyperactive excitatory synapses associated with excitation–inhibition imbalance, altered network dynamics, and broad dysregulation of genes involved in synaptic homeostasis.

Researchers reveal that TNF alpha unmasks a metabolic impairment in the enteric malate-aspartate shuttle. This dysfunction acts as a key pathological bridge linking intestinal inflammation to the neurodegeneration seen in Parkinson’s disease.

This Protocol Extension details the standardized production of iPS cell-derived macrophages in an intermediate-scale benchtop bioreactor, providing a valuable tool for academic labs focused on human immune cells.

This study reports the successful reprogramming of human blood cells to pluripotent stem cells using small molecules.