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The interactions of nanoparticles with the body are dynamic and complex. This Perspective examines the application of different multi-omics tools to investigate nano–bio interactions in vitro and in vivo.
Integrating bioprinting with organoid technology can enhance tissue engineering by improving complexity, reproducibility and scalability. This Review discusses living materials in bioprinting, current organoid bioprinting methods, support baths and future innovations that could advance complex tissue development and applications.
The authors introduce a new printing technology called dynamic interface printing (DIP), which leverages an acoustically modulated air–liquid interface to rapidly create supportless structures without requiring specialized chemistry or complex optical systems.
Recognition of life as a dynamic, non-equilibrium and evolvable process suggests that the realization of synthetic life could be achieved by the in vitro integration of metabolic and evolutionary processes.
Biased and unrepresentative scientific data can lead to misleading conclusions and potentially harm patients. Artificial intelligence (AI) might be able to help make data more representative, but only if a standardized approach to assessing the quality of AI-generated data is established.
The extracellular matrix remains under-recognized as a sex-dependent entity. Designing culture environments that account for sex as a biological variable requires considering not only cellular sex, but also the usage of sex-specific scaffolds to create a holistically sex-accurate platform.
Biological nanopores can be designed for high-sensitivity sequencing of peptides and proteins. This Review discusses different approaches towards nanopore-based protein sequencing, outlining methods to distinguish amino acids, control protein translocation and detect post-translational modifications.
Compared to linear mRNA, circular RNAs offer greater stability during storage and delivery, along with more sustained effects due to their circular structure. This Review provides an overview of circRNA-based therapeutics, highlighting key engineering principles, associated challenges and strategies to address such challenges.
Extracellular vesicles are being explored for various biomedical applications, but face challenges with regard to isolation, characterization and manufacturing. This Review delineates the physico-chemical landscape of extracellular vesicles to identify the distinct challenges associated with the manufacturing and isolation of extracellular vesicles from biofluids and suggests opportunities to address them.
Review articles are our bread and butter. Here, we would like to offer some insights on how to craft a comprehensive and authoritative assessment of a field.
This Review details the use of multifunctional magnetic nanoparticles in advanced magnetic imaging modalities and therapeutic hyperthermia. The potential of magnetic nanoparticles for imaging-guided precision heating of tumours and the need for integrated magnetic imaging and heating platforms are highlighted.
The widespread use and translation of engineered in vitro tissues, such as organoids, organ-on-chip devices and microphysiological models, will require designs that can be preserved by cryopreservation. Here, we outline the factors that affect their cryopreservation, highlighting the challenges that remain to be addressed.
Commercializing cultured meat requires cost reduction and quality improvement. Microbial cell factories can produce cost-effective and high-quality raw materials for cultured meat production.
Lithography-based 3D printing has emerged as a valuable tool with which to develop hydrogels for biomedical applications. This Review discusses lithography-based 3D printing techniques, offers guidance for resin formulation and provides a step-by-step manual for printing hydrogels intended for clinical applications.
The global rise of drug-resistant bacteria, including those resistant to last-resort antibiotics, poses an urgent health threat. This Review discusses antibiotic re-engineering strategies to increase the activity and improve the efficacy of existing antibiotics against multidrug-resistant infections.
Biomass, such as lignocellulose, can be processed into value-added products and energy, offering a promising solution for carbon-neutral chemical and fuel production. This Review discusses engineering strategies, including systems and synthetic biology approaches, to optimize lignocellulose biorefineries.
Women’s health research has long been underfunded, in part owing to stigmas associated with conditions that primarily affect women. Equitable health research funding requires transparency from funding agencies, investment in women-centred innovations, support for women in science and a cultural shift in how health issues are viewed.
Stem cell-based embryo models can recapitulate developmental processes such as tissue patterning and morphogenetic events from pre-implantation to early organogenesis. This Review discusses how bioengineering approaches can be used to generate more efficient, controllable, reproducible and scalable embryo models.
Synthetic data can be created by deep generative models to address challenges associated with real data, such as privacy issues, bias and data scarcity. This Review discusses the generation and application of synthetic data in biomedicine and bioengineering, including quality assessment and validation.
