Research Highlights in 2011

A UBD containing ankyrin repeats determines the linkage specificity of TRABID.

A new method for high-resolution imaging using a standard wide-field microscope.

Structural insight into the DKK1-mediated inhibition of WNT signalling.

Two studies reveal roles for B-type lamins in organogenesis and cell proliferation.

MCRS1 stabilizes K-fibres and spindle assembly in a RAN·GTP-dependent manner.

ncRNAs regulate gene localization between distinct nuclear subcompartments.

PINK1 phosphorylates MIRO; parkin then degrades MIRO to halt mitochondrial movement.

Epidermal stem cell activity is directly regulated by core clock proteins.

Lyn senses H₂O₂at wound sites and mediates neutrophil migration.

Symmetric intestinal stem cell division drives adaptive midgut growth.

The N-end rule degradation pathway is part of the oxygen-sensing mechanism in plants.

E2F1 oscillations control endocycle progression inDrosophila melanogaster.

Paternal mitochondria are degraded by fertilization-induced autophagy.

The ubiquitin E3 ligase SCF^βTrCPtargets the mTOR inhibitor DEPTOR for degradation.

Four studies reveal the existence of ceRNAs, which regulate each other's expression.

Autophagy proteins function in a non-canonical single-membrane vesicle degradation pathway.

New findings challenge the idea that sirtuins promote longevity.

Midbodies promote stem cell pluripotency and cancer tumorigenicity.

PRMT5 methylates RAF proteins to decrease their stability and reduce ERK activation.

NR4A proteins regulate DNA double-strand break repair independently of transcription.