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This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

This study reveals that in people with first episode of psychosis receiving oral antipsychotic medication, switching to long-acting injectable antipsychotic therapy may reduce psychotic relapses, especially in vulnerable subgroups, such as those with prior relapses or non-adherence to antipsychotic medication.

This study reports age-dependent negative correlations between temporal changes in maximal leaf area index and growing season length, indicating contrasting leaf acclimation strategies driving vegetation greening in young versus old deciduous broadleaf forests.

Many thermophiles that are abundant in geothermal systems have never been cultivated and are poorly understood. Here, Lai et al. describe the cultivation of one such organism, a deeply branching member of the archaeal phylum Thermoproteota, and provide evidence that it has evolved to specialize in branched-chain amino acid metabolism.

The large uncertainty in land carbon-cycle estimates remains a major challenge. Here, the authors show that vegetation biogeography drives much of this uncertainty, with 75% of the uncertainty reducible using existing biogeography map from remote sensing.

Since 2000, China has attempted to vegetate huge portions of eroded landscape in its south west, bordering Vietman, Laos, and Myanmar. This study finds that this ecological engineering is combating desertification as vegetation regrows and stores carbon.

Climate warming is projected to expand plant phosphorus limitation from 47% to 59% of global silicate rock areas. However, phosphorus release from accelerated chemical weathering of these rocks offsets about 15.5% of this increase.

An analysis of the effect of mesophyll diffusion on the dynamics of the uptake of carbonyl sulfide by plants estimates global contemporary gross primary productivity to be 157 (±8.5) petagrams of carbon per year.

Research in the tropics is unevenly distributed across regions and biomes. Here, the authors find that moist broadleaf forests account for 73% of all tropical citations but cover 29% of the land area, while drier, climate-vulnerable areas with fewer trees remain under-sampled and under-cited.

The terrestrial biosphere absorbs a large fraction of emitted CO₂, and thus, plays a critical role in climate change projections. Here, the authors use satellite leaf area and in-situ CO₂ measurements to show that most Earth system models largely underestimate photosynthetic carbon fixation in high latitudes.

Global land cover conversions increased carbon uptake during 1982 to 2019, with newly established forests in the Northern Hemisphere driving gains that counterbalanced emissions from tropical deforestation.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

Here the authors present a local ancestry inference algorithm with superior accuracy, and use it to shed light on the demographic histories of Latin Americans and the Askenazi Jewish, and to map a candidate Viking immune locus under selection in the British population.

Remote sensing often detects higher vegetation greenness for croplands than for forests, despite forests having a greater leaf area. This study shows that this is an artefact of shadows caused by forest structures and explores how to correct for this when interpreting global vegetation change data.

The extent to which excess carbon dioxide causes a ‘fertilization effect’ varies across biomes and as a function of water supply, finds a study examining data from 14 CO₂ experimental sites.

Satellite records combined with global ecosystem models show a persistent and widespread greening over 25–50% of the global vegetated area; less than 4% of the globe is browning. CO₂ fertilization explains 70% of the observed greening trend.

Carbon sequestration by Siberian forests has been low over the past decade due to disturbances that have decreased live biomass and increased dead wood, according to passive microwave observations.

Developing predictive methods to identify patients with high risk of severe COVID-19 disease is of crucial importance. Authors show here that by measuring anti-SARS-CoV-2 antibody and cytokine levels at the time of hospital admission and integrating the data by unsupervised hierarchical clustering/machine learning, it is possible to predict unfavourable outcome.

Little millet is an orphan crop offering a promising yet underutilized option in the pursuit of food and nutritional security. Here, the authors report its genome assembly, and elucidate its recent tetraploid structure, sub-genome dominance, and the genetic basis for micronutrient content.

Greening—increasing leaf area index—affects regional climate in a number of contradictory ways. The net global effect is now revealed to be cooling that has offset the equivalent of 12% of global land-surface warming over the past 30 years.

Conventional type 1 dendritic cells (cDC1) can boost the precursor exhausted T cell population thought to be essential for efficacy of immune checkpoint therapy. Here the authors enhance this cellular network using Flt3L to expand cDC1s and then map the movement of T cells and DCs between tumors and lymph nodes.

The authors jointly assess the changes in land and ocean net primary production from 2003 to 2021. They show contrasting trends, with overall planetary increases (0.11 ± 0.13 PgC yr⁻¹) driven by terrestrial enhancement and offset by oceanic decline.

Combining fossil records and vegetation modelling, this study shows that global warming during the Paleocene-Eocene Thermal Maximum 56 million years ago exceeded the adaptation capacity of vegetation, disrupting the global climate regulation system.

Ecosystems accumulate carbon for several days after moisture pulses, but this benefit fades as soil dries and heat stress intensifies, according to an analysis that uses carbon flux-tower observations, Earth system models, machine learning, and satellite images.

The authors use a water balance approach to show that drought-driven evapotranspiration increases are widespread and depend on the magnitude of precipitation and total water shortage anomalies. Earth system models underestimate the probability of drought-driven evapotranspiration increases in drier regions.

Satellite-derived indices used to estimate gross primary production and carbon cycling rarely differentiate between boreal mosses and vascular plants, despite differences in photosynthetic capacity. Here, the authors show that this may have led to an overestimation of the boreal carbon budget.

The atmosphere and biosphere are intrinsically coupled systems. Here, the authors integrate multiple datasets from hourly to decadal timescales and show that a hydrometerological envelope constrains ecosystem variability through time.

Lactobacillus associates with vaginal protection from HIV-1 infection. Here, the authors show that lactobacilli extracellular vesicles contain bacterial proteins and metabolites that inhibit HIV-1 infection in T cells and in human cervico-vaginal and tonsillar tissues ex vivo via altering viral Env proteins.

The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.

Membrane bioreactors play a pivotal role in protecting the water environment and achieving a sustainable urban water cycle, but their operational stability faces great challenges due to membrane fouling. A study now provides an intelligent strategy to enable early warning of fouling events.

Forest management primarily drives the carbon sink enhancement in China from 2001 to 2021, achieving carbon gains at a rate over 4 times higher than afforestation, according to an integrated framework combining remote sensing-driven and climate-driven process models.

Isoprene emissions are commonly estimated using satellite measurements and model simulations. Here, using eddy covariance, the authors report higher emission rates over the Amazon forest than those estimated with these techniques and a relationship between terrain elevation and isoprene emissions.

The photosynthetic capacity of forest ecosystems is an important variable in the global carbon cycle. Here, it is shown that older, more diverse forests have less fluctuation between years in photosynthetic capacity.

Climate warming increases evapotranspiration (ET) more in boreal peatlands than in forests. Observations show that peatland ET can exceed forest ET by up to 30%, indicating a stronger warming response in peatlands. Earth system models do not fully account for peatlands and hence may underestimate future boreal ET.

Model projections of future drylands distribution using a proxy based on atmospheric aridity show expansion under climate change, but may not be an accurate representation. An alternative index based on ecohydrological variables such as water limitation shows no global expansion of drylands.

Forest coverage loss from wildfires and deforestation increases flood risk for large-scale river catchments by reducing interception, according to analysis of data from twenty-one watersheds in Australia.

The predicted rise in CO₂ levels during this century is expected to stimulate crop yields, offsetting losses from greater drought. But this study, using free-air CO₂ enrichment, shows soybean yield gains dropping to zero as drought stress increased.

Understanding the role of biodiversity in maintaining the provision of Nature’s Contributions to People is critical to sustainability. This study finds a substantial contribution of high-biodiversity areas to the regulation of air quality, climate and freshwater quantity, with important implications for conservation efforts.

Climate warming has increased forest fire sizes, amplifying postfire summer warming, with broadleaf trees mitigating this effect; climate-smart forestry should increase broadleaf tree cover to manage future fire risks.

Fully quantifying the influence of vegetation on atmospheric chemistry remains challenging. Here, the authors show that forest canopy shading and turbulence significantly modify air pollution throughout the atmospheric boundary layer, and must be taken into account in models of the atmosphere.

Pseudotaxus is a sister genus to Taxus but lacks a complete taxane biosynthetic pathway. Here, the authors assemble the genome of P. chienii and reveal that the presence of a functional taxane 2α-O-benzoyl transferase in Taxus genus extends the existing taxane biosynthesis pathway into a complete Taxol biosynthesis pathway.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

mGWAS reveals ZmICE1 as a key hub for integrating amino acid metabolic pathways and cold tolerance in maize. Natural variation in ZmICE1 promoter regulates the binding affinity of ZmMYB39, which confers the diverse cold tolerance in maize.

Papaya is a trioecious species with XX females, XY males, and XY^h hermaphrodites, and the combination of Y and Y^h chromosomes is lethal. Here, the authors identify the degeneration of the YY lethality gene on the Y chromosome as the causal balancing lethal factor that reenforces dioecy and stabilizes balanced sex ratios.

Plant diversity stabilizes grassland soil temperature by boosting soil organic carbon and increasing plant leaf area, according to an 18-year plant diversity experiment.

An autonomous robotic platform enables high-throughput, low-cost, and high-volume phenotypic measurements in maize canopies, facilitating the understanding of genotype, environment, and management interactions (GxExM) with high accuracy.

Kersting’s groundnut is an underutilised crop that is locally important, tolerant to drought and critical to food security. Here, the authors report its genome assembly, population genetics analyses, and candidate genes for seed coat colour.