Search

The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery. Herein the authors report an enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones using a chiral Lewis acid catalyst for the synthesis of hetero-bicyclo[3.1.1]heptane.

Sodium-air batteries are appealing energy storage systems due to high theoretical energy density and high sodium abundance. But they are plagued with low efficiency and large overpotential. Here, authors report long-term reversibility over 1000 cycles with 99% efficiency using a cascade electrocatalysis strategy based on Na[Li_1/3Ru_2/3]O₂ electrodes.

This work reports a Lewis-acid coordinated strategy to improve stability of a 4.8 V-class PEO-based battery. The batteries using Lewis-acid coordinated electrolytes and Ni-rich cathodes achieve high voltage stability of 4.8 V over 300 cycles.

Silencers play a critical role in gene transcription regulation. Here, the authors developed the Ss-STARR-seq technique to identify tens of thousands of silencers in human cells. These silencers possess unique epigenetic features and are capable of influencing cellular phenotypes.

Solid-state sodium batteries represent more sustainable options as they combine resource abundance with safety. This work advances their performance, particularly fast cycling lifespan, to an unprecedented level utilizing a hybrid electrolyte.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

The Greenberger-Horne-Zeilinger states are multipartite entangled quantum states with strong non-local entanglement. Here the authors generate large-scale states of this type with up to 60 qubits and show that discrete time crystals can effectively protect such fragile states.

Of the 3 classes of dimeric lindenane sesquiterpenoids, only type I And II have been targeted in total synthesis. Here, the authors report a unified strategy to synthetically access the 3 classes of lindenane sesquiterpenoids dimers by developing a [4 + 2] cycloaddition between a common furyl diene and various dienophiles.

Radicals are expected to be inactive on metal surfaces. Here the authors describe general intermolecular radical transfer reactions on Ag and Cu surfaces and confirm the reaction mechanism by extensive control experiments.

The lifetime of a qubit in a circuit quantum electrodynamics architecture can exceed the break-even point through quantum error correction, representing a key step towards scalable quantum computing.

Host–guest materials open up the possibility of tuning physical properties based on the addition of appropriate guests. Here, a flexible, porous coordination polymer is reported, in which the addition of guest molecules significantly alters the thermal expansion properties as well as deforming the crystal lattice.

The separation of acetylene and carbon dioxide by porous materials requires delicate control over the pore size. Herein, the authors fine-tune the pore size at sub-nanometer scale in a series of isoreticular metal-organic frameworks to control the acetylene/carbon dioxide separation performance; subtle structural differences lead to remarkable performance enhancement.

The African swine fever virus represents a threat to global pig production. Here, the authors determine the cryo-EM structures of ASFV RNA polymerase, and suggest that the M1249L subunit may modulate polymerase activity in cells.

A 2 nm displacement resolution of a centimetre-sized object in a 3 cm cavity is demonstrated.

By analysing the genome of over 9,000 pig-associated isolates, this study shows that modernized agricultural systems have favoured the acquisition of antimicrobial resistance genes, population expansion and global transmission of pig-enriched Salmonella over the past century.

A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.

Chondrocyte senescence is known to play a role in the occurrence and progression of osteoarthritis. Here, the authors demonstrate that 10-hydroxy-2-decenoic acid (10-HDA), a small molecule derived from the food nutrient royal jelly, can prevent osteoarthritis by delaying chondrocyte senescence through targeting aspartyl β-hydroxylase.

The piezoelectric and pyroelectric coefficients of ferroelectric materials are critical to improving the sensitivity and detection limit in sensing. Here, the authors report an interface engineering strategy using a PEDOT:PSS penetrating electrode, that realizes high pressure and temperature sensitivity.

Preclinical characterization of the SARS-CoV-2 M^pro inhibitor RAY1216 shows improved in vivo pharmacokinetics compared with nirmatrelvir.

Increased low frequency cortical oscillations are observed in neuropathic pain. Here the authors perform Ca²⁺ imaging of DRG sensory neurons in a mouse model of neuropathic pain, and show that synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations are observed.

Direct imaging and tuning of flat band localization in kagome materials remains a challenge. Here, scanning tunneling microscopy and photoemission spectroscopy are used to study FeSn, revealing real-space localization and magnetic tuning of the flat band state within the Fe₃Sn kagome lattice layer.

Gas sorption studies in porous materials typically reflect their overall gas uptake. Now, using a ‘gas adsorption crystallography’ method, the gas adsorption isotherms of two metal–organic frameworks (MOFs) have been quantitatively decomposed into sub-isotherms that reflect the pore-filling behaviour of various guests in the different types of pores present in the MOFs.

Geometric phase is of fundamental interest and has practical application in quantum computation. Here the authors observe continuous-variable geometric phase in a superconducting circuit and demonstrate a multi-qubit controlled phase gate protocol based on this geometric effect.

Layer dependence is an important aspect to properties of van der Waals materials. Here, the authors obtain layer dependent multiple polarization states in 3 R MoS₂ and propose a generalized model to describe their ferroelectric switching processes.

A solution-processing step has been used to prepare quantum-well structures that comprise a thin layer of perovskite sandwiched between two layers of conjugated oligothiophene derivatives. The band gap of the resulting 2D hybrid perovskites can be fine-tuned by functionalizing the organic component, which also improves the stability of the system.

Yijun Ruan and colleagues report the draft genome of the sweet orange, Citrus sinensis. Their data suggests sweet orange originated from a cross between pummelo and mandarin.