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The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A tunable magnetic nanochains platform (EVGpro) enables tandem enrichment, proteomic, and N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids. EVGpro identifies N-glycoprotein signatures and two asthenozoospermia subtypes.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

This Protocol provides detailed instructions for performing NAP-seq, an RNA sequencing technique for profiling full-length sequences of noncapped RNAs with various terminal modifications at single-nucleotide resolution.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Aryl thianthrenium salts are valuable in photocatalysis but traditionally require external electron donors for activation. Herein, the authors report an energy transfer strategy for the activation of aryl thianthrenium salts, eliminating the need for external donors.

Ideally smart textiles should be able to thermoregulate, be moisture permeable, and have a stable working performance, though it is challenging to balance these properties. Here the authors design a fabric, by reducing polymer chain aggregation, balancing the ideal properties for smart fabrics.

The commercialization of organic solar cells has been hindered by the limited device stability. Here, authors show that the connectivity of electron transport network is a key factor determining electron transport and device stability, with polymeric acceptors likely to establish such a network.

Tear secretion from lacrimal gland is essential for ocular health, but the regulatory role of sympathetic nervous system is unclear. The authors show that sympathetic activation suppresses lacrimal tear secretion and aggravates dry eye disease via NA–Adra1a–Ucp2 signaling.

Autonomous electric vehicles reduce operational emissions but increase manufacturing emissions due to rebound effects. Recycling helps, but their full life cycle emits 8% more greenhouse gases. Embrace renewable energy, circular economy, cleaner manufacturing, and improved efficiency.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

The electrochemical NH₃ synthesis from NO reduction faces challenges, including weak NO adsorption and sluggish proton supply. Here, the authors report a ternary Co/Co₃O₄/CoB heterostructure promotes NO adsorption while boosting H₂O dissociation and subsequent hydrogenation to produce NH3.

Hume’s ground tit (Parus humilis) was once thought to belong to the Corvidae family, which includes crows and jays. Qu et al.sequence and analyse Hume's ground tit genome, as well as two additional tits and a ground jay, and establish its evolutionary position as the world's largest tit.

Injectable hydrogels are being explored for Rheumatoid Arthritis (RA) therapy, but most existing injectable hydrogels address only specific aspects of the RA pathological microenvironment. Here, the authors report an injectable bioadhesive and lubricating hydrogel, that prevents cartilage wear, provides long-term anti-inflammatory effects, and repairs damaged cartilage for RA therapy.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Molecular interactions are of great importance in materials science. Here, the authors use the confinement effect and low-dose imaging to reveal the confined molecules and evaluate the strength of host-guest interactions in different material systems.

Enhancing traffic capacity to alleviate urban congestion is a key objective for connected autonomous driving. Shi-Teng Zheng and colleagues report a sixfold traffic capacity improvement enabled by a communication topology involving only the two vehicles ahead.

Two distinct patterns in the protective effect of natural infection against reinfection in the Omicron variant versus pre-Omicron eras show that SARS-CoV-2 immune protection is shaped by dynamic interaction between host immunity and viral evolution.

International shipping is a major emitter of greenhouse gases, but quantifying responsibilities has been difficult. This study uses satellite-observed data on vessels to determine the emissions from and subsequent health impacts of US–China bilateral trade of goods.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

In layered transition metal oxides as cathode active materials for Na-ion batteries, Na⁺ diffusion kinetics are impacted by Na⁺/vacancy ordering. Here, the authors suggest that the P2-type Na_2/3Ni_1/3Mn_2/3O₂ with large zigzag ordering exhibits high Na⁺ mobility and thus superior rate capability.

Single-cell CRISPR screening combines pooled CRISPR screening with scRNA-seq analysis to expand the resolution power of genetic screening. Here, the authors develop MUSIC, a computational pipeline for analyzing single-cell CRISPR screening data.

The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response.

Metabolic enzymes often form supramolecular complexes to improve product yield. Here the authors use short peptide tags to create scaffold-free assemblies and synthetic metabolic nodes.

A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

Yellow-seed trait is preferred in rapeseed breeding as it can greatly improve seed oil yield and quality. Here, the authors assemble the genome of two rapeseed lines with yellow-seed and black-seed phenotypes, and clone an R2R3-MYB-type transcription factor encoding gene as a key regulator of seed color.

Natural proteins exhibit rich structural diversity based on the folds of an invariably linear chain. Here the authors design a single-domain GFP catenane as the counterpart of conventional linear GFP with enhanced thermal resilience and to provide a robust scaffold for making fusion protein catenanes.

Yao et al. observe and characterize genomic redistribution of the PBAF complexes upon PBRM1 loss, leading to sustained RELA occupancy by SMARCA4, activation of the NF-kB pathway and enhanced kidney tumourigenesis.

Ferroptosis is a novel form of regulated cell death associated with lipid oxidation. Here, the authors demonstrate that the proferroptosis signal is activated and drives vascular aging by inducing senescence in vascular smooth muscle cells.

Elucidating the nature of topological magnets is at quantum frontier. Here the authors report a topological charge-entropy relation in TbMn₆Sn₆ that goes beyond conventional electron behavior and points to a transport visualization of Chern gapped Dirac fermions.

Stable operation of acetylene hydrochlorination remains a challenge due to over-chlorination of Ru. Here, the authors propose a Ru-In atom pair with d-p orbital coupling that switches the thermodynamics of chlorination process and improves stability.

SHP2 interacts with ACK1 kinase to erase pY54-H3 (Tyr54-phosphorylation of histones H3) epigenetic marks and triggers Androgen receptor transcriptional program. It explains genital abnormalities and infertility in LEOPARD syndrome patients, and AR upregulation in prostate cancer.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

A diet–microorganism pathway involving conjugated linoleic acid, interleukin-18, intraepithelial lymphocytes and the transcription factor hepatocyte nuclear factor  4γ modulates the host mucosal immune system.

Rice coordinates recruitment of the root microbiota to optimize nitrogen acquisition from soil.