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Accurate quantum mechanical benchmarks modeling ligand interactions with protein pockets are key in drug design. Here, such a large dimers dataset is created, analyzed, and probed with many methods

Giardini et al. present an imaging method that combines quantitative measurements of cardiac electrophysiology with high-resolution three-dimensional structural reconstructions, enabling the detection of arrhythmogenic electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

Analysis of human Robertsonian chromosomes originating from 13, 14 and 21 reveal that they result from breaks at the SST1 macrosatellite DNA array and recombination between homologous sequences surrounding SST1.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Kidney shortages limit treatment options for patients with end-stage kidney disease, prompting exploration of xenotransplantation. Here, the authors show that a genetically modified pig kidney sustained essential functions in a living human for 51 days, informing future clinical strategies.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In this study, the authors describe SANA, a nitroalkene derivative of salicylate, as a potential activator of creatine-dependent energy expenditure and thermogenesis in adipose tissue. Preclinical and clinical data from this paper also suggest that SANA improves glucose homeostasis and promotes weight loss in mice and humans.

Cells typically migrate toward stiffer substrates via durotaxis, relying on focal adhesions. Here, the authors show that confined cells can migrate up friction gradients without focal adhesions, revealing a mode of directed migration called frictiotaxis.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Hydrogel materials have emerged as versatile platforms for biomedical applications. Here this group reports an mRNA lipid nanoparticle-incorporated microgel matrix for immune cell recruitment/antigen expression and presentation/cellular interaction thereby eliciting antitumor efficacy with a single dose.

The understanding of defects in bromide-based perovskites remains elusive. Electric biasing and introducing bromide in the precursor solution during crystal growth is shown to significantly reduce defects in formamidinium lead bromide.

Extending quantum photonics’ capabilities from simple linear-optics-based schemes to universal quantum computing presents several challenges, but intermediate regimes with some degree of adaptivity might already bring practical advantages. Here, the authors experimentally emulate an adaptive Boson Sampling scheme using post-selection, and apply it to a data classification task.

Using AI and computer simulations, this study finds that the Earth’s inner core may have a cubic structure, which better matches how seismic waves travel through it than the hexagonal form found in pure iron.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Sharks’ dorsal fins are thought to assist propulsion and turns while pectoral fins are thought to oppose sharks’ negative buoyancy. Here, Payne and colleagues show that hammerhead sharks use an exaggerated dorsal fin to generate lift by swimming on their side.

Mobile impurities can be useful probes of quantum states. Here, the authors theoretically identify polarons formed on the edge of topological insulating states, termed chiral polarons, that can be used to probe topological matter.

Maskless high-resolution patterning of structural colours is demonstrated using a new material called ‘M-Ink’. The period of the material is patterned magnetically and a photochemical process immobilizes the structure in a polymer network.

A comparison of alpha diversity (number of plant species) and dark diversity (species that are currently absent from a site despite being ecologically suitable) demonstrates the negative effects of regional-scale anthropogenic activity on plant diversity.

Here, the authors image twisted bilayer graphene using scanning microwave imaging microscopy, revealing structures with sizes down to 1 nm. They show that is possible by using spontaneously forming nanoscale water menisci that concentrates the microwave fields in small regions.

Transport of colloidal cargoes to target sites can be done by controlling active carriers, like self-propelled bacteria, under external stimuli. Koumakis et al.show that bacteria can autonomously achieve the same goal when moving over pre-designed asymmetric microstructures.

The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocampus to enable cross-species and functional interpretation.

Hibernating brown bears maintain their muscle mass, which is due to a drastic reduction in metabolic rate. Here, De Napoli et al. show that this is partly due to a reduction of energy consumption by the motor protein myosin in resting skeletal muscle that increases the super relaxed state stability.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Using a three-pronged approach — spanning field-driven negative capacitance stabilization to increase intrinsic energy storage, antiferroelectric superlattice engineering to increase total energy storage, and conformal three-dimensional deposition to increase areal energy storage density — very high electrostatic energy storage density and power density are reported in HfO₂–ZrO₂-based thin film microcapacitors integrated into silicon.

Resonantly-excited quantum-dot-based single photon sources feature very high purity, but also limited efficiency due to the need to suppress the residual pump. Here, the authors demonstrate a workaround, performing optical pumping and signal collection in two orthogonal modes inside a nanophotonic circuit.

An autonomous DNA-origami nanomachine powered by the chemical energy of DNA-templated RNA-transcription-consuming nucleoside triphosphates as fuel performs rhythmic pulsations is demonstrated. In combination with a passive follower, the nanomachine acts as a mechanical driver with molecular precision.

An optical method for the temporal and spatial reconstruction of the electric field of few-cycle pulses is developed. The method is based on two attosecond technologies: extreme-ultraviolet interferometry and a directional electric field detector.

Azacitidine (AZA) response in myelodysplastic neoplasms is unpredictable. Here, the authors show in a phase 2 trial that while global methylation changes did not differ by response, baseline and initial CpG methylation differences in HSPCs predicted AZA response.

It has been previously shown theoretically that the average path length of random walks inside a closed domain is invariant. Here the authors demonstrate that this invariance property can be used to predict the mean residence time of swimming bacteria exploring structured micro-environments.

Comprehensively understanding the ultrafast dynamics of the insulator-to-metal transition in vanadium dioxide is a long-standing challenge. Here, the authors measure the electronic and structural phase transitions in the first hundred femtoseconds.

Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels, inhibiting the microbiota and enabling pathogen growth through aerobic respiration.

Multiomic phenotyping provides molecular insights into complex physiological processes and pathologies. The study uses 18 omics platforms to analyze biofluids from 391 participants. It constructs a comprehensive molecular network based on omics integration, revealing insights into diabetes and other traits.

Neural mechanisms underlying deep brain strokes are not fully understood. Here authors demonstrate that spreading depolarizations occur in the intact contralesional hippocampus during unilateral stroke. These spreading depolarizations are more common in female mice and allow preservation of hippocampus-dependent learning.

Analysis of single nuclei RNA-sequencing data across eight major brain cell types identifies putative causal associations between cell-type-specific expression and brain phenotypes.

European heatwaves have raised interest in the impact of land-cover conditions on temperature extremes. Analyses of observations from an extensive network of flux towers in Europe reveal a difference in the response of forests and grassland to extreme or long-lasting heat.

Most genomics research cohorts are made up of participants of European ancestry, which limits the reach of precision medicine. Here, the authors describe the genetic diversity in the All of Us research program, which is enriched in underrepresented ancestries.

Analysis of individual-level patient records from Brazil reveals that the extensive shocks in COVID-19 mortality rates are associated with pre-pandemic geographic inequities as well as shortages in healthcare capacity during the pandemic.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).