Methylated genes have been proposed as diagnostic and prognostic biomarkers for patients with both muscle-invasive and non-muscle-invasive bladder cancer. In this Review, the authors describe the body of evidence on gene methylation and the associations with progression, recurrence and survival, which might contribute to clinical decision-making and individualized treatment.
- Raju Kandimalla
- Angela A. van Tilborg
- Ellen C. Zwarthoff