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Atrophic age-related macular degeneration (AMD) results in visual impairment. Here the authors report interim analysis of open-label single group feasibility trial using a wireless photovoltaic subretinal implant in patients with atrophic AMD, and report that the patients exhibited prosthetic visual perception with acuity closely matching the pixel size during the 18-24 month follow-up period.

Nonmagnetic colloidal nanocrystals demonstrate magnetic properties due to spins of dangling bonds at their surface resulting in formation of dangling-bond magnetic polarons.

Two dimensional forms of silicon offer different conductive properties to that of the bulk material, promising applications in new electronic technologies. Here, the authors report the fabrication of bilayer silicenes which, unlike their monolayer form, are indirect bandgap semiconductors.

Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.

Samples from the asteroid (101955) Bennu, returned by the OSIRIS-REx mission, include sodium-bearing phosphates and sodium-rich carbonates, sulfates, chlorides and fluorides formed during evaporation of a late-stage brine.

The structure of magnetic nanoparticles has a strong influence on the properties of these materials at present being considered for magnetic-storage applications. It is now shown that size and shape of magnetic nanoparticles such as CoPt affect the transition from an ordered to a disordered phase, highlighting the need to take morphology into account to understand the structural properties.

Ultrafast pulses with controlled parameters are desirable in many applications including probing materials and their interaction with light. Here the authors demonstrate a technique for polarization control of XUV beam using high-harmonic generation and polarization shaping.

Probing the evolution of mixed-phase states in materials offers unique insights into the microscopic mechanism of phase transitions. Here, Mattoni et al. report imaging of nanoscale formation and growth of insulating domains across the metal-insulator transition in NdNiO₃thin films, uncovering a rich interplay between structural and electronic degrees of freedom.

The genetically encoded sensor hCRAFi-CCR2 enables detection of chemokines binding to the CCR2 receptor, such as the main ligand CCL2 but also CCL7, CCL8, CCL13 and CXCL1. The sensor’s capabilities are demonstrated in cell culture and in various mouse models in vivo.

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Ultrashort high-intensity laser pulses change the properties of dielectrics in different ways. One unexpected outcome is light amplification in an excited dielectric, observed in a two-colour pump–probe experiment.

Neural mechanisms underlying goal-directed actions are not fully understood. Here authors show that in mice, the secondary motor cortex determines it by integrating motor thalamic inputs that promote action based on action values and orbitofrontal inputs that bias to non-action.

Sample orientation is crucial to ensure optimal image quality in light microscopy. Here the authors enable multi-axis orientation of fixed mouse embryos and shrimp, and live zebrafish embryos and larvae by introducing magnetic beads and rotating the sample with a magnetic field in a microscope.

A dark exciton is an electron–hole pair with a very long radiative recombination time. Whereas their ’bright’ counterparts are studied in depth, dark states in quantum dots are often regarded as a nuisance. Now, a technique has been found for optically accessing dark excitons, which might make them more useful than first thought.

The serial assessment of the functional parameters of leukocytes isolated via an inertial microfluidic system from 50 μl of peripheral blood from sepsis patients provides significantly more prognostic information than leukocyte counting.

The study reveals that CSLD5-mediated cell wall synthesis in plant meristems regulates tissue mechanics, influencing growth and gene expression. Targeting CSLD5 expression in specific cell layers can restore growth defects and enhance crop yield, offering a strategy for breeding high-yield plants.

Olfactomedin-2 is a pleiotropic glycoprotein emerging as a regulator of energy homeostasis via the hypothalamus. The present findings functionally connect adipose-specific OLFM2 to obesity, and highlight its significance in maintaining adipocyte commitment to avoid metabolic disease.

Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.

Relativistic jets observed from transient neutron stars throughout the Universe produce bright flares for minutes after each X-ray burst, helping to determine the role individual system properties have on the speed and revealing the dominant launching mechanism.

Crystal symmetries play an important role in the properties of materials, but allow little dynamic control once the materials have been grown. Here, the authors show that conducting oxides sandwiched between independently switchable ferroelectric films achieve tunable symmetry for controllable properties.

Nonlinear interactions such as parametric down-conversion and four-wave mixing are limited by transverse and longitudinal walk-off effects. Here, Pérez et al. demonstrate bright, tunable, diffraction-limited twin-beam radiation by ensuring that signal or idler pulse propagates in the direction or velocity of the pump.

Direct epitaxial growth of vertically stacked layered materials is a promising route towards scalable fabrication of van der Waals heterostructures. Here, the authors demonstrate molecular beam epitaxy of semiconducting MoSe₂on a hBN/Ru(0001) substrate.

A bright, long-duration gamma-ray burst observed by the Swift observatory has hybrid high-energy properties, suggesting that its origin is the merger of a compact binary.

Broadband frequency combs are a key enabling technology for frequency metrology and spectroscopy. Here, the authors demonstrate that the spectrum of a soliton microcomb can be extended by bichromatic pumping resulting in two combs that synchronize their repetition rate via cross-phase modulation.

Bacterial biofilms are aggregates of surface-associated cells embedded in an extracellular polysaccharide (EPS) matrix. Here, the authors describe a unique mode of collective movement by self-propelled, surface-associated spherical microcolonies with EPS cores in the gliding bacterium Flavobacterium johnsoniae.

This study reveals that lysosomal dysfunction in senescent cells impairs lipid peroxidation and ferroptosis under cystine deprivation, uncovering a new mechanism of ferroptosis resistance linked to cellular senescence and providing a therapeutic strategy for age-related diseases.

Cryo-electron and atomic force microscopy shed light on how fibrils of the protein tau, which accumulate in the brain of people with Alzheimer’s disease, can be disassembled by short peptides, providing a possible route towards developing treatments.

Observation of new lava flows between different Magellan radar scans in regions of Sif Mons and Niobe Planitia confirms that volcanism on Venus is still ongoing. This evidence also suggests the planet’s volcanic activity exceeds previous estimates.

Long-period radio transients emit powerful polarized signals lasting minutes to an hour. The discovery of ASKAP J1935+2148, a source showing diverse emission modes that resemble neutron-star behaviour, challenges existing ideas of these phenomena.

Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Cell division in many archaea requires the coordinated activities of two distinct FtsZ proteins, which are part of the midcell division ring. Here, Liao et al. show that an additional protein, CdpA, organises and anchors the FtsZ-based division ring at midcell in haloarchaea.

Snail is involved in the regulation of epithelial-mesenchymal transition and metastasis. Here, the authors show that the metabolite β-hydroxybutyrate promotes pancreatic cancer metastasis through protecting Snail from degradation.

Excitons play an important role in the optical properties of 2D semiconductors, but their spatial characterization is usually constrained by the diffraction limit. Here, the authors report near-field optical spectroscopy of 2D transition metal dichalcogenides with 20 nm resolution, revealing their spatially dependent excitonic spectra and complex dielectric function.

In this work, authors utilise a prefractionation natural product extract screening platform, which uncovers coniotins, lipopeptaibiotics with broad antifungal activity and a mechanism of action that targets fungal cell wall β-glucan.

ChReef is an optogenetic actuator for sustained optogenetic control of excitable cells in a variety of preclinical applications.

It is elusive to manufacture room temperature phosphorescent (RTP) materials through effective and ambient processing approaches. Here the authors report the production of photocured RTP materials using lignosulfonate to act as RTP chromophore and photoinitiator, achieving easy preparation, low cost and good performance.

Recycling China’s end-of-life trucks promises 44 billion United States dollars and reduces carbon emissions by 58 million metric tons by 2050, according to a multi-factor future projection modeling approach

The decision to form a fruiting body have been studied extensively, however, the mechanical events that trigger the creation of multiple cell layers is poorly understood. Here the authors find M. xanthus cells adjust their reversal frequency to control mechanical stresses that triggers layer formation in the colonies.

Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and the resulting cardiomyocyte cell death and cardiac dysfunction.

Cellpose3 employs deep-learning-based approaches for image restoration to improve cellular segmentation and shows strong generalized performance even on images degraded by noise, blurring or undersampling.

RAPID (rapid autofocusing via pupil-split image phase detection) is a sample-agnostic real-time autofocus method for widefield microscopy. RAPID removes most image degradation in large, cleared samples for enhanced quantitative analyses.