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Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent lysotoxicity via microautophagy.

A lightweight, modular assistive soft exosuit is introduced, which supports shoulder and elbow movement in individuals with cervical spinal cord injury. The device enhances endurance and range of motion, reduces muscle effort and improves clinical test scores.

Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.

Timely identification and treatment of cerebral lesions in high-risk neonates are crucial. Here, the authors present a deep learning system that extracts multiple standard views from neonatal cranial ultrasound videos and diagnoses severe cerebral lesions with high accuracy, outperforming junior radiologists.

Copper-based organic light-emitting diodes are low-cost alternatives to precious metal-based counterparts. Here, the authors develop copper(I) thermally activated delayed fluorescent emitters with colors spanning from blue to near infrared, and achieve device lifetime close to 3700 h at 1000 cd/m².

Mutational effect transfer learning (METL) is a protein language model framework that unites machine learning and biophysical modeling. Transformer-based neural networks are pretrained on biophysical simulation data to capture fundamental relationships between protein sequence, structure and energetics.

Profiling transcriptional crosstalk between promoters and cell-type-specific enhancers allows large gene cargo delivery.

Chronic alcohol use in humans and mice downregulates small intestinal mAChR4 and reduces goblet-cell-associated antigen passage formation, disrupting antimicrobial immunity.

A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

The function of histone lysine β-hydroxybutyrylation (Kbhb) is unclear in plants. Here, the authors show that H3K9bhb is enriched at transcription start sites in rice and regulates gene expression during immune responses.

The genetic basis of grapevine thermotolerance remains poorly understood. Here, the authors identify WRKY transcription factor TTC4 as a positive regulator of thermotolerance and reveal its possible upstream repressor SPL13 and downstream target genes HSP18.1 and APX3.

Quantum entanglement — used for quantum key distribution, communication and teleportation — is a fragile resource. Researchers investigate the conditions under which optical loss destroys entanglement, and report states that are particularly robust to such losses.

Two-dimensional materials offer potential for coherent light sources but face challenges with integration in silicon photonics. Here, the authors demonstrate a high-performance on-chip photonic circuit based entirely on a van der Waals heterostructure for coherent light generation, guiding and modulation.

Current estimates of dissolved CO₂ in subduction-zone fluids based on thermodynamic models rely on a very sparse experimental data base. Here, the authors show that experimental graphite-saturated COH fluids interacting with silicates at 1–3 GPa and 800 °C display unpredictably high CO₂ contents.

Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promoting extracellular matrix (ECM) organization and facilitating bone regeneration through matricrine effects.

The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct lineage origins, we show that local factors specify their ultimate identities.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

ACTA2 p.R179 variants cause pediatric strokes due to moyamoya disease (MMD)-like occlusions. Here, the authors show that Acta2^R179C/+ smooth muscle cells are immature, causing MMD-like lesions that are reversed by altering cellular metabolism.

A general two-step intercalation and cation-exchange strategy is used to produce a library of highly ordered magnetic intercalation superlattices with tunable chemical modulations and magnetic ordering.

Triplet-triplet annihilation upconversion efficiency is limited by the energy matching of the sensitizer and acceptor parts. Here, the authors implement a dual annihilator system in chiral liquid crystals to achieve efficient circularly polarized emission.

Controlled operation of individual molecular machines on a larger scale, 10-100 nm, remains challenging. Here, Kuzyk et al.demonstrate a light-driven plasmonic nanosystem that can amplify the molecular motion of azobenzene through a host nanostructure and translates it into reversible chiroptical response.

Achieving fairness while preserving privacy in medical imaging tasks remains a significant challenge. Here, the authors present and comprehensively evaluate a federated learning framework to tackle both fairness and privacy issues, using a flexible regularization term to integrate multiple fairness criteria.

With only a few known useful room-temperature multiferroics, other ways of achieving materials showing magnetism as well as electrical polarization are sought. The discovery that the ferroelectric BaTiO₃ also shows magnetism at room temperature at the interface with iron or cobalt marks a new approach to achieving multiferroic properties.

The efficiency of nonlinear optical processes in 2D materials is often reduced by weak light-matter interactions and crystal symmetry constraints. Here, the authors report the enhancement of classical second-harmonic generation in hexagonal boron nitride and quantum spontaneous parametric down-conversion in NbOCl₂ flakes by combining them with Au or SiO₂/Au substrates.

A quantum simulator can follow the evolution of a prescribed model, whose behaviour may be difficult to determine. Here, the emergence of magnetism is simulated by implementing a quantum Ising model, providing a benchmark for simulations in larger systems.

By intercalating layered 2D atomic crystals with selected chiral molecules, a new class of chiral molecular intercalation superlattices is reported, demonstrating highly ordered structures and achieving high tunnelling magnetoresistance and spin polarization ratios.

In ferromagnetic thin films, spin torque applied to nanometre-scale areas excites localized magnetic self-oscillations, or reduces net magnetization if applied uniformly. Here, Duan et al.show how 1D geometrical confinement allows for coherent self-oscillations to be excited over extended length scales.

A transducer that generates microwave–optical photon pairs is demonstrated. This could provide an interface between optical communication networks and superconducting quantum devices that operate at microwave frequencies.

Yang Bai and colleagues propose a hypersonic levitation and spinning technique for rapid tissue dissociation. The method enables fast acquisition of high-quality single cells, preserves rare cell types, and supports single-cell sequencing.

Rare-earth-doped crystals are prime candidates for qubit storage that could be easily interfaced with photonic systems. Towards this end, Siyushev et al.show the initialization, coherent manipulation and readout of single-electron spins on cerium ions embedded in YAG crystals.

A ferroelectric semiconductor field-effect transistor, which uses the two-dimensional ferroelectric semiconductor α-In₂Se₃ as a channel material, could offer enhanced capabilities compared with conventional ferroelectric field-effect transistors in non-volatile memory applications.

Existing computational approaches to predict long-range regulatory interactions do not fully exploit high-resolution Hi-C datasets. Here the authors present a Random Forests regression-based approach to predict high-resolution Hi-C counts using one-dimensional regulatory genomic signals.

The controlled movement of optically active components represents a challenge for nanooptical applications. Here the authors demonstrate a gold nanorod walker that performs directional walking along a DNA origami track and where the individual nanoscale steps can be monitored by optical spectroscopy in real time.

Designing efficient AI hardware capable of creating artificial general intelligence remains a challenge. Here, the authors present an approach for the on-demand generation of complex networks within a single memristor by harnessing device dynamics with intrinsic cycle-to-cycle variability and demonstrate the effectiveness of memristive complex network-based reservoirs.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.