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Asymmetrical distribution of tau pathology in Alzheimer’s disease is linked to asymmetrical amyloid-beta deposition, not reduced brain connectivity, suggesting regional vulnerability plays a key role in determining the distribution of tau pathology.

Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.

Analysis of shallow-water marine carbonate samples from 101 stratigraphic units allows construction of a record of lithium isotopes from the past 3 billion years, tracking the evolution of the global carbon and silicon cycles.

Here, the authors develop pluripotent stem cell-derived kidney organoids by mimicking in vivo proximal differentiation, providing a model to study nephron development, injury responses, and a platform for therapeutic discovery.

Stable and robust topological edge modes are observed at finite temperatures in an array of 100 programmable superconducting qubits because of emergent symmetries present in the prethermal regime of this system.

John et al. show that upon classical activation, macrophages undergo nitric oxide-driven reprogramming of nucleotide metabolism, which affects immune functions and responses.

Redox flow batteries are promising energy storage systems but are limited in part due to high cost and low availability of membrane separators. Here, authors develop a membrane-free, nonaqueous 3.5 V all-organic lithium-based battery and demonstrate its operation in both static and flow conditions.

Melting of sanukitoid-infused basement beneath greenstone roots produced lithium-rich granites and lithium-pegmatite in the Australian Archean Cratons, according to an analysis of geochemical and isotopic data.

Membrane proteins often form clusters that shape membrane function. Here, authors determine the cryo-EM structure of human Stomatin in its native membrane, revealing how it assembles into a ring-like complex that organizes a distinct membrane microdomain.

A mutant-selective AKT inhibitor shows potential as a targeted therapy for breast cancer, enabling enhanced target engagement and avoiding the dose-limiting toxicity associated with pan-AKT inhibitors.

In vivo gene editing hinges on identifying an ideal delivery vehicle from numerous candidates. Here, authors establish the GFP-on mouse model capable of translating successful adenine base editing to a fluorescent readout thus enabling the rapid evaluation of genome editing delivery vehicles.

The approval of first line immune checkpoint blockade (ICB) has improved outcomes for patients with metastatic non-small cell lung cancer (mNSCLC), however, whether patients would benefit more from ICB alone or alongside chemotherapy is unclear. Here, the authors develop a machine-learning based approach to help guide individual treatment selection patients with mNSCLC.

Automated organic synthesis is often limited to making simple molecules, requiring a small number of synthetic steps, because of the complexity and variety of organic molecules. Now, a robotic platform has been instructed to build complex structures, such as the core fragment of (+)-kalkitoxin, in a stereochemically controlled and iterative manner.

A versatile, human iPSC-derived nephron engineering platform that permits scrutiny of axial patterning mechanisms is critical for identifying the origins of human kidney disease. Here they describe a system in which synchronized human nephron structures are generated from pluripotent stem cells, enabling manipulation of axial segmentation.

All-solid-state lithium-based batteries require high stack pressure during operation. Here, we investigate the mechanical, transport, and interfacial properties of Li-rich magnesium alloy and show enhanced performance at low pressure and ambient temperature for alloy-based electrodes with less than 5 at% Mg content.

The molecular mechanisms of cell entry for the recently identified highly pathogenic feline coronavirus FCoV-23 are characterized in detail.

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capillary–venous networks contribute to age-related hypoperfusion and white matter damage in mice.

Enhancer-gene selectivity establishes gene expression networks during development. Here, the authors link Evf2 enhancer-gene guidance and seizure gene regulation, Evf2 RNA binding sites and chromosomal RNP recruitment domains, and homeodomain motif recognition to support multilayered mechanisms.

Chemical weathering of silicate rocks occurs along a continuum from terrestrial to marine environments.

There has been recent progress in the synthesis of complex intertwined supramolecular topologies. In this study, Liet al.report the self-assembly of an intertwined structure based on a universal 3-ravel.

Kang et al. define distinct spatial niches within glioblastoma (GBM) tumors according to their infiltrative nature and report that glioma cells induce microglia and macrophage alignments through plexin-B2 signaling, sustaining the invasive behavior of GBM.

Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma, and they prospectively validate its prognostic value.

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effectiveness.

Gold nanostructures have shape-dependent properties, making synthetic control over their morphology critical. Here, the authors use dynamic compression to obtain a variety of gold nanoarchitectures, which are formed at very fast timescales by the controlled coalescence of spherical particle arrays.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

MGAT1 is a glycosyltransferase critical for the synthesis and maturation of complex N-glycans. Here, the authors show that MGAT1 modulation of CD73 glycosylation and function regulates tumor immune response in triple-negative breast cancer.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

The full characterisation of lithium-ion electrolytes is of paramount importance for the continued development and innovation of lithium ion and lithium metal batteries. Here, the authors present a new experimental setup to obtain all key electrolyte parameters using operando Raman microspectroscopy

The efficacy of CAR-T cells against solid tumors is still limited by immunosuppressive factors. Here, the authors show that engineering of CAR T cells with A1R enhances their efficacy against solid tumors in vitro and in vivo.

NGPS is an accelerated aging condition, caused by a mutation in BAF. Here, we report the results of an unbiased, whole genome CRISPR microscopy screen aimed at restoring nuclear envelope integrity in NGPS patient cells.

Altering the composition of the spacer layers present in iron-based superconductors is one strategy for increasing the temperature below which they superconduct. Now, intercalating FeSe with molecular spacer layers is also shown to enhance the superconducting transition temperature.

Solid electrolyte interphase (SEI) formation on Li-ion battery anodes is critical for long-term performance. Here, the authors use operando soft X-ray absorption spectroscopy in total electron yield mode to resolve the chemical evolution of the SEI during electrochemical formation on silicon anodes.

The application of metal fluorides as cathodes for lithium ion batteries has been hindered by inadequate understanding of their electrochemical capabilities. Reversible conversion reaction in iron fluoride nanocrystals is shown to be due to topotactic cation diffusion and nucleation of metallic particles.

Deep learning enhanced chemical imaging delineated polymorphic Aβ plaques in situ. Cored plaques were associated with increased Aβ1-40 and 3pE-42 deposition. A distinct, coarse-grained plaque phenotype was specific to AD, showed increased neuritic dystrophy and an Aβ-pattern similar to CAA.